Results 51 to 60 of about 48,911 (292)
Hematopoietic stem cell regulation by the proteostasis network [PDF]
, 2020 Purpose of reviewProtein homeostasis (proteostasis) is maintained by an integrated network of physiological mechanisms and stress response pathways that regulate the content and quality of the proteome.
Signer, Robert AJ +3 more
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The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Cells, 2018 In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite for cell growth, functioning, adapting to changing micro-environments, and responding to extracellular stress.
Zhen Dong, Hongjuan Cui
doaj +1 more source
Cells, 2022 Proteostasis, a portmanteau of the words protein and homeostasis, refers to the ability of eukaryotic cells to maintain a stable proteome by acting on protein synthesis, quality control and/or degradation.
Jonas Johannes Papendorf +2 more
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Proteostasis in complex dendrites
Nature Reviews Neuroscience, 2013 Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ∼10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage ...
Cyril Hanus, Erin M. Schuman
openaire +3 more sources
Linking cellular proteostasis to yeast longevity [PDF]
, 2018 Proteostasis is a cellular housekeeping process that refers to the healthy maintenance of the cellular proteome that governs the fate of proteins from synthesis to degradation.
Marques, Maria Belém Sousa Sampaio +3 more
core +1 more source
Molecular Glue Degraders and the Expanding Design Space of Drug Discovery
CHIMIASmall-molecule drug discovery has long centered on inhibiting protein function through high-affinity binding to defined active sites. An emerging alternative shifts the focus from inhibition to rewiring - modulating protein-protein interactions within ...
Zuzanna Kozicka
doaj +1 more source
Cell Reports, 2013 The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6.
Matthew D. Shoulders +9 more
doaj +1 more source
Neural Plasticity, 2018 Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with ...
Pablo Olivero +8 more
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PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis
, 2019 Protein homeostasis (proteostasis) is at the core of cellular functions. The European network PROTEOSTASIS was created to steer research and foster collaborations in the interconnected fields of posttranslational modifications by ubiquitin family members
Core, Group Members of PROTEOSTASIS +4 more
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Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus [PDF]
, 2021 Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental ...
Seyfried, Nicholas T +19 more
core +1 more source