Results 61 to 70 of about 43,964 (292)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Proteostasis in pediatric pulmonary pathology

, 2014
Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy route.
Korbinian Ballweg, Meiners, S., Silke Meiners, Ballweg, K.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Extracellular proteostasis prevents aggregation during pathogenic attack

, 2020
In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells.
Della C. David, Huang, Chaolie, Sommer, Ralf J., Ralf J. Sommer, Sandhu, Aneet, Jung, Raimund, Christian Rödelsperger, Sommer, R., Rödelsperger, C., David, D., Gallotta, Ivan, Ivan Gallotta, Waltraud Röseler, Huang, C., Sandhu, A., Blersch, J., Aneet Sandhu, Raimund Jung, Gallotta, I., Sinem Agilkaya, Rödelsperger, Christian, Agilkaya, Sinem, Röseler, Waltraud, Agilkaya, S., Blersch, Jane L., Jane L. Blersch, Chaolie Huang, Jung, R., Maximilian Peters, Röseler, W., David, Della C., Haslbeck, M., Martin Haslbeck, Peters, M.   +33 more
core   +1 more source

Crosstalk between Biomolecular Condensates and Proteostasis

, 2022
Proper homeostasis of the proteome, referred to as proteostasis, is maintained by chaperone-dependent refolding of misfolded proteins and by protein degradation via the ubiquitin-proteasome system and the autophagic machinery.
Amzallag, Emmanuel, Hornstein, Eran, Emmanuel Amzallag, Eran Hornstein   +3 more
core   +1 more source

Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans.

PLoS ONE, 2020
The proteostasis network comprises the biochemical pathways that together maintain and regulate proper protein synthesis, transport, folding, and degradation.
Emily H Green, Elise A Kikis
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Redox regulation of proteostasis

Journal of Biological Chemistry
Oxidants produced through endogenous metabolism or encountered in the environment react directly with reactive sites in biological macromolecules. Many proteins, in particular, are susceptible to oxidative damage, which can lead to their altered structure and function.
Long Duy Duong, James D. West, Kevin A. Morano   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Pharmacology and Dual Role of Proteostasis in Amyloidoses

Biophysica
Cellular protein quality control comprises the ubiquitin proteasome system, autophagy, and molecular chaperones, which maintain proteostasis in healthy tissues.
Angela Albanese, Manasi M. Natu, Paul M. Seidler   +2 more
doaj   +1 more source