Results 81 to 90 of about 51,687 (291)

Probing the Proteostasis Network

Chemistry & Biology, 2010
PTI has built itself up as an entity that can test the concept of proteostasis modulators. The company is using its capabilities in transcriptional, proteomic, and functional profiling to probe the proteostasis network in human diseases. “The goal of all of this work is to increase the health span, the number of years we are healthy,” says Kelly.To ...
openaire   +2 more sources

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

PROTEOSTASIS AS A SIGNALING DEVICE AND THERAPEUTIC TARGET

, 2011
The term ‘conformational disorders’ was created recently for the numerous pathological situations due to the accumulation of aberrant proteins (or normal ones in excess).
CENCI S, SITIA , ROBERTO
core  

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Dietary-Induced Signals That Activate the Gonadal Longevity Pathway during Development Regulate a Proteostasis Switch in Caenorhabditis elegans Adulthood

Frontiers in Molecular Neuroscience, 2017
Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis).
Netta Shemesh, Lana Meshnik, Nufar Shpigel, Anat Ben-Zvi   +3 more
doaj   +1 more source

The proteostasis burden of aneuploidy

Biological Chemistry
Abstract Aneuploidy refers to chromosome number abnormality that is not an exact multiple of the haploid chromosome set. Aneuploidy has largely negative consequences in cells and organisms, manifested as so-called aneuploidy-associated stresses.
Prince Saforo Amponsah, Zuzana Storchová   +1 more
openaire   +2 more sources

Proteostasis network deregulation signatures as biomarkers for pharmacological disease intervention

, 2019
Protein homeostasis, or proteostasis, is fundamental to cellular and organismal health. Proteostasis collapse is linked to diverse diseases, including neurodegeneration and cancers.
Brehme, Marc, Sverchkova, Angelina, Voisine, Cindy   +2 more
core   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.

PLoS ONE, 2013
Disturbed proteostasis as a particular phenotype of the aging organism has been advanced in C. elegans experiments and is also conceived to underlie neurodegenerative diseases in humans.
Philipp Ottis, Bianca Topic, Maarten Loos, Ka Wan Li, Angelica de Souza, Daniela Schulz, August B Smit, Joseph P Huston, Carsten Korth   +8 more
doaj   +1 more source

Proteostasis and Diseases of the Motor Unit

Frontiers in Molecular Neuroscience, 2016
The accumulation in neurons of aberrant protein species, the pathological hallmark of many neurodegenerative diseases, results from a global impairment of key cellular processes governing protein synthesis/degradation and repair mechanisms, also known as the proteostasis network (PN).
Rinaldi, C, Mäger, I, Wood, M
openaire   +3 more sources