Results 101 to 110 of about 57,493 (305)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Dietary-Induced Signals That Activate the Gonadal Longevity Pathway during Development Regulate a Proteostasis Switch in Caenorhabditis elegans Adulthood

Frontiers in Molecular Neuroscience, 2017
Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis).
Netta Shemesh, Lana Meshnik, Nufar Shpigel, Anat Ben-Zvi   +3 more
doaj   +1 more source

Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]

, 2017
The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David, Nguyen, Basile, Rios, Paolo De Los, Seifert, Udo   +3 more
core   +2 more sources

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

eLife, 2018
We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins.
Angela M Phillips, Michael B Doud, Luna O Gonzalez, Vincent L Butty, Yu-Shan Lin, Jesse D Bloom, Matthew D Shoulders   +6 more
doaj   +1 more source

Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis [PDF]

, 2017
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins ...
Amerik, Anckar, Apaja, Arndt, Arndt, Aviram, Balch, Ballinger, Bar-Lavan, Barrott, Bartel, Bays, Becuwe, Behrends, Bengtson, Boban, Boban, Bodnar, Boomsma, Bordallo, Brandman, Brehme, Broersen, Buchner, Calderwood, Carra, Catlett, Choe, Christianson, Chu, Ciechanover, Ciocca, Ciryam, Commerford, Connell, Craig, Crippa, Crosas, Cuervo, Cuervo, Cyr, Dai, Davies, Defenouillere, Deng, Deyter, Donati, Douglas, Douglas, Dunker, Duttler, Ehrlich, Eisele, Ellis, Fan, Fang, Fang, Fang, Fang, Ferreira, Finley, Finley, Foresti, Fourie, Fredrickson, Gallagher, Gamerdinger, Gardner, Garrido, Goldberg, Guerriero, Guo, Han, Hartl, Hatakeyama, Heck, Hemmingsen, Hessa, Hettema, Higy, Hondele, Hondele, Hoppe, Iwata, Jana, Jego, Jiang, Jin, Joshi, Kahn, Kampinga, Kaplan, Katsogiannou, Kaushik, Kaushik, Keller, Kenyon, Kerscher, Kettern, Khmelinskii, Kim, Kitagawa, Koegl, Komander, Koren, Kraft, Kuhlbrodt, Kuhlbrodt, Kumar, Kuo, Kwon, Laba, Labbadia, Lakshmipathy, Lee, Lerch-Bader, Levine, Li, Li, Lopez, Lopez-Otin, MacGurn, Maier, Matsumura, Mattiroli, Maurer, McDonough, Meacham, Mehnert, Meng, Merz, Metzger, Min, Mishra, Mizushima, Morano, Morimoto, Morimoto, Morimoto, Morishima, Murata, Murata, Nahleh, Nillegoda, Nillegoda, Nillegoda, Park, Park, Paul, Petrucelli, Powers, Powers, Prasad, Qian, Ranford, Rape, Ravid, Rees, Roberts, Roberts, Rodina, Rodrigo-Brenni, Rosenbaum, Ruggiano, Russell, Rüb, Rüdiger, Saez, Saibil, Salminen, Samant, Schopf, Shahsavarani, Shao, Shiber, Shiga, Shin, Singh, Singh, Singh, Soss, Sowa, Spiechowicz, Stuttmann, Sulistio, Sultana, Summers, Sung, Swanson, Taipale, Takayama, Tasaki, Tasaki, Tawo, Taylor, Terman, Tzankov, Ulbricht, Urushitani, VanPelt, Venkatesh, Verma, Vilchez, Walther Dirk, Wang, Wang, Willhoft, Williams, Xie, Xu, Xu, Yonashiro, Yu, Zargari, Zhang, Zhang, Zhao, Zhao, Zhou, Zuehlke, Zuiderweg   +220 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

The Nuclear Lamina: Protein Accumulation and Disease

Biomedicines, 2020
Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw   +7 more
doaj   +1 more source

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source