Results 1 to 10 of about 94,343 (283)

Redefining Molecular Chaperones as Chaotropes [PDF]

Frontiers in Molecular Biosciences, 2021
Molecular chaperones are the key instruments of bacterial protein homeostasis. Chaperones not only facilitate folding of client proteins, but also transport them, prevent their aggregation, dissolve aggregates and resolve misfolded states.
Jakub Macošek, Guillaume Mas, Sebastian Hiller   +2 more
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Molecular Chaperones: Molecular Assembly Line Brings Metabolism and Immunity in Shape [PDF]

Metabolites, 2020
Molecular chaperones are a set of conserved proteins that have evolved to assist the folding of many newly synthesized proteins by preventing their misfolding under conditions such as elevated temperatures, hypoxia, acidosis and nutrient deprivation ...
Haoxin Zhao, Lydia N. Raines, Stanley Ching-Cheng Huang   +2 more
doaj   +4 more sources

Molecular chaperones in stroke-induced immunosuppression [PDF]

Neural Regeneration Research, 2023
Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.
Haoduo Qiao, Qing Xu, Yunfei Xu, Yao Zhao, Nina He, Jie Tang, Jie Zhao, Ying Liu   +7 more
doaj   +2 more sources

Editorial: Molecular Chaperones and Neurodegeneration [PDF]

Frontiers in Neuroscience, 2017
Peer ...
Cintia Roodveldt, Tiago F. Outeiro, Janice E. A. Braun   +2 more
doaj   +8 more sources

Advances in the structures, mechanisms and targeting of molecular chaperones [PDF]

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +2 more sources

Beneficial Handling of Molecular Chaperones (Chaperonotherapy) in Glioblastoma and Neuroblastoma: Novel Therapeutic Targets or Potential Agents? [PDF]

Cells
Molecular chaperones, especially Heat Shock Proteins (HSPs), play complex, context-dependent roles in cancer, particularly in nervous system (NS) tumors like glioblastoma (GBM) and neuroblastoma (NB).
Maria Antonella Augello, Nima Shadan, Giuseppa D’Amico, Rosario Barone, Celeste Caruso Bavisotto, Federica Scalia, Alessandra Maria Vitale   +6 more
doaj   +2 more sources

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

Nature Communications, 2016
Molecular chaperones are recognized to interfere with protein aggregation, yet the underlying mechanisms are largely unknown. Here, the authors develop a kinetic model that reveals the variety of distinct microscopic mechanisms through which molecular ...
Paolo Arosio, Thomas C. T. Michaels, Sara Linse, Cecilia Månsson, Cecilia Emanuelsson, Jenny Presto, Jan Johansson, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles   +9 more
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Editorial: Molecular chaperones and human disease [PDF]

Frontiers in Molecular Biosciences, 2022
Graham Chakafana, Stanley Makumire, Xolani Henry Makhoba   +2 more
doaj   +2 more sources

Editorial: Molecular chaperones and polyamines in disease [PDF]

Frontiers in Molecular Biosciences
Stanley Makumire, Graham Chakafana, Xolani H. Makhoba   +2 more
doaj   +2 more sources

Molecular chaperones and Parkinson's disease

Neurobiology of Disease, 2021
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs). Mutations in PD-related genes lead to neuronal pathogenesis through various
Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang   +7 more
doaj   +1 more source