Results 1 to 10 of about 110,947 (209)
Molecular chaperones and Parkinson's disease
Neurobiology of Disease, 2021 Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs). Mutations in PD-related genes lead to neuronal pathogenesis through various
Shenglan Hu +7 more
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Cells, 2021 The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Molecular chaperones are a major component of the
Lisha Wang +4 more
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Plants, 2023 Most pectic rhamnogalacturonan-II (RG-II) domains in plant cell walls are borate-bridged dimers. However, the sub-cellular locations, pH dependence, reversibility and biocatalyst involvement in borate bridging remain uncertain. Experiments discussed here
Rifat Ara Begum, Stephen C. Fry
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The DNAJ gene family in yerba mate (Ilex paraguariensis): genome-wide identification, structural characterization, orthology based classification and expression analysis [PDF]
Rodriguésia, 2023 Dry leaves and twigs of yerba mate are widely infusion-consumed in southern Southamerica. Endemic and adapted to the Atlantic Forest, its extensive full-sun monoculture links to diverse biotic (pest, pathogens) and abiotic stresses (solar radiation ...
Patricia Mabel Aguilera +4 more
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How DNA and RNA Viruses Exploit Host Chaperones to Promote Infection
Viruses, 2021 To initiate infection, a virus enters a host cell typically via receptor-dependent endocytosis. It then penetrates a subcellular membrane, reaching a destination that supports transcription, translation, and replication of the viral genome.
Kaitlyn Speckhart +2 more
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eLife, 2022 Signal-anchored (SA) proteins are anchored into the mitochondrial outer membrane (OM) via a single transmembrane segment at their N-terminus while the bulk of the proteins is facing the cytosol.
Layla Drwesh +9 more
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The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-Dependent UMPylation
Cell Reports, 2020 Summary: Sensing stressful conditions and adjusting the cellular metabolism to adapt to the environment are essential activities for bacteria to survive in variable situations. Here, we describe a stress-related protein, YdiU, and characterize YdiU as an
Yinlong Yang +17 more
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Genetics and Molecular Biology, 2005 Expressed Sequence Tags (ESTs) sequencing provides reliable and useful information concerning gene expression patterns in the genomic context. Our group used bioinformatics to identify and annotate 5'EST-contigs belonging to the molecular chaperones ...
Thiago C. Cagliari +3 more
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Molecules, 2021 The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct region defined area penumbra in preclinical models of brain ischemia.
Federica Mastroiacovo +7 more
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The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins
Biomolecules, 2021 Protein homeostasis is an essential component of proper cellular function; however, sustaining protein health is a challenging task, especially during the aerobic lifestyle.
Meytal Radzinski +3 more
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