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2013
Hsp70 proteins function as ATP-dependent molecular chaperones, which are involved in the folding of newly synthesized polypeptides, the assembly of multi-protein complexes and the transport of proteins across cellular membranes. Hsp70 is crucial for maintaining protein homeostasis, thus disregulation of Hsp70 is found in many human diseases, such as ...
Yaoyu Chen, Wenlai Zhou
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Hsp70 proteins function as ATP-dependent molecular chaperones, which are involved in the folding of newly synthesized polypeptides, the assembly of multi-protein complexes and the transport of proteins across cellular membranes. Hsp70 is crucial for maintaining protein homeostasis, thus disregulation of Hsp70 is found in many human diseases, such as ...
Yaoyu Chen, Wenlai Zhou
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Hsp70 Escort Protein: More Than a Regulator of Mitochondrial Hsp70
Current Proteomics, 2018Hsp70 members occupy a central role in proteostasis and are found in different eukaryotic cellular compartments. The mitochondrial Hsp70/J-protein machinery performs multiple functions vital for the proper functioning of the mitochondria, including forming part of the import motor that transports proteins from the cytosol into the matrix and inner ...
David O. Nyakundi +2 more
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Interaction of Hsp70 chaperones with substrates
Nature Structural & Molecular Biology, 1997Determination of the structure of the substrate binding domain of the Escherichia coli Hsp70 chaperone, DnaK, and the biochemical characterisation of the motif it recognizes within substrates provide insights into the principles governing Hsp70 interaction with polypeptide chains.
Rüdiger, Stefan +2 more
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2013
Aging or senescence in biology is defined as the process of gradual loss of important body functions and cells, and in particular, the inability of cells to reproduce and cope with stress. Important features of an aging cell include the progressive accumulation of damaged proteins, abnormal protein aggregates and oxidative stress.
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Aging or senescence in biology is defined as the process of gradual loss of important body functions and cells, and in particular, the inability of cells to reproduce and cope with stress. Important features of an aging cell include the progressive accumulation of damaged proteins, abnormal protein aggregates and oxidative stress.
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Hsp70 proteins in protein translocation
2001Publisher Summary Hsp70 proteins are essential components of the protein translocation systems of the endoplasmic reticulum (ER) and mitochondria. The role of Hsp70s in protein translocation is not confined to the ER and mitochondria. For most proteins of the ER, translocation is coupled with protein synthesis.
Ryan, Michael T., Pfanner, Nikolaus
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2013
Depending on the location, HSP70 has different, often opposite effects on carcinogenesis. Intracellular HSP70 contributes to tumour development by: (1) supporting protein homeostasis in a tumour cell, thus protecting the cell from the adverse conditions of external inflammation; (2) contributing to the proliferation of tumour cells because HSP70 ...
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Depending on the location, HSP70 has different, often opposite effects on carcinogenesis. Intracellular HSP70 contributes to tumour development by: (1) supporting protein homeostasis in a tumour cell, thus protecting the cell from the adverse conditions of external inflammation; (2) contributing to the proliferation of tumour cells because HSP70 ...
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2019
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?????????????????????????????? ????????????, ?? ?????????? ?????? ???????????????? ???????????? ?????????????????????? ?????? ?????????????????? ???????????????????????? ?????????????? ???????? hsp70 ??????????????????. ?????????????? ?????????????????? ???????????? ???????? ?? ???????????????????????? ???????????? ?????? ???????? ?????????????????? ???
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Novartis Foundation symposium, 2008
Chaperokine is a term recently coined to better describe the dual role of extracellular heat shock protein as both chaperone and cytokine. The augmentation of intracellular Hsp72 expression has clearly been demonstrated to be cytoprotective; with the ability to activate anti-apoptotic and anti-inflammatory pathways, exerting inhibitory effects on cell ...
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Chaperokine is a term recently coined to better describe the dual role of extracellular heat shock protein as both chaperone and cytokine. The augmentation of intracellular Hsp72 expression has clearly been demonstrated to be cytoprotective; with the ability to activate anti-apoptotic and anti-inflammatory pathways, exerting inhibitory effects on cell ...
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2021
Results of the Western-Blot-analysis of heat shock protein 70 kDa (Hsp70) in leaves of 8 species of plants from 7 angiosperm families, different in their ecology, are presented. The tested plants were affected by water deficit, flooding and heat stress under natural or experimental conditions.
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Results of the Western-Blot-analysis of heat shock protein 70 kDa (Hsp70) in leaves of 8 species of plants from 7 angiosperm families, different in their ecology, are presented. The tested plants were affected by water deficit, flooding and heat stress under natural or experimental conditions.
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