Results 1 to 10 of about 15,770,117 (207)

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Nature Communications, 2021
Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration.
Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy, Juan Carlos Izpisua Belmonte   +14 more
doaj   +1 more source

A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Cell & Bioscience, 2022
Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou   +6 more
doaj   +1 more source

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

Nature Communications, 2021
Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric ...
Thomas A. Johnson, Ville Paakinaho, Sohyoung Kim, Gordon L. Hager, Diego M. Presman   +4 more
doaj   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, Dylan H. de Vries, M. V. D. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sönmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg, J. Kettunen, Bernett Lee, Futao Zhang, Ting Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, Julia Dmitrieva, Mahmoud Elansary, Benjamin P. Fairfax, M. Georges, B. Heijmans, A. Hewitt, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rotzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. ’. ’t Hoen, J. Thiery, A. Tönjes, J. van Dongen, M. van Iterson, J. Veldink, U. Völker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. V. van Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, P. Visscher, Jian Yang, M. Scholz, J. Powell, G. Gibson, T. Esko, L. Franke   +107 more
semanticscholar   +1 more source

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Nature Communications, 2020
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

The role of CPEB family proteins in the nervous system function in the norm and pathology

Cell & Bioscience, 2021
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl, Mariya Zhukova   +4 more
doaj   +1 more source

Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

Nature Communications, 2022
Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges, Hugo Sepulveda, J. Carlos Angel, Eric Johnson, Susan Palomino, Roberta B. Nowak, Arshad Desai, Isaac F. López-Moyado, Anjana Rao   +8 more
doaj   +1 more source

Effective gene expression prediction from sequence by integrating long-range interactions

Nature Methods, 2021
How noncoding DNA determines gene expression in different cell types is a major unsolved problem, and critical downstream applications in human genetics depend on improved solutions.
Žiga Avsec, Vikram Agarwal, D. Visentin, J. Ledsam, A. Grabska-Barwinska, Kyle R. Taylor, Yannis Assael, J. Jumper, Pushmeet Kohli, David R. Kelley   +9 more
semanticscholar   +1 more source

Gene Expression Commons: an open platform for absolute gene expression profiling. [PDF]

, 2012
Gene expression profiling using microarrays has been limited to comparisons of gene expression between small numbers of samples within individual experiments.
Bhattacharya, Deepta, Dill, David L, Ehrlich, Lauren IR, Fathman, John W, Inlay, Matthew A, Rossi, Derrick J, Sahoo, Debashis, Seita, Jun, Serwold, Thomas, Weissman, Irving L   +9 more
core   +2 more sources

SCANPY: large-scale single-cell gene expression data analysis

Genome Biology, 2018
Scanpy is a scalable toolkit for analyzing single-cell gene expression data. It includes methods for preprocessing, visualization, clustering, pseudotime and trajectory inference, differential expression testing, and simulation of gene regulatory ...
F. Wolf, Philipp Angerer, Fabian J Theis
semanticscholar   +1 more source