Results 31 to 40 of about 8,056,076 (252)

Gene Therapy for Acquired and Genetic Cholestasis

Biomedicines, 2022
Cholestatic diseases can be caused by the dysfunction of transporters involved in hepatobiliary circulation. Although pharmacological treatments constitute the current standard of care for these diseases, none are curative, with liver transplantation ...
Javier Martínez-García, Angie Molina, Gloria González-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou   +4 more
doaj   +1 more source

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

BMC Genomics, 2017
Background High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease ...
Vladimir A. Kuznetsov, Zhiqun Tang, Anna V. Ivshina   +2 more
doaj   +1 more source

FGF1 orchestrates circadian hepatic triglyceride secretion

Nature Communications
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) represents a global health crisis associated with dysregulated hepatic triglyceride (TG) synthesis, oxidation and secretion.
Benan Pelin Sermikli, Sihao Liu, Kyeongkyu Kim, Linnea Hases, Tim van Zutphen, Ashley Untereiner, Jocelyn Torres, Mingxiao He, Lillian Crossley, Yang Dai, Jonathan Zhu, Chandra Lekha Koopari, Weiwei Fan, Morgan L. Truitt, Johan W. Jonker, Annette R. Atkins, Michael Downes, Ronald M. Evans   +17 more
doaj   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Nature Communications, 2018
The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu, Nail Fatkhutdinov, Takeshi Fukumoto, Benjamin G. Bitler, Pyoung Hwa Park, Andrew V. Kossenkov, Marco Trizzino, Hsin-Yao Tang, Lin Zhang, Alessandro Gardini, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis

npj Breast Cancer, 2017
Stem cells: protein not needed for stem cell activity in mammary gland A protein considered necessary for mammary stem cell activity turns out to be dispensable. What’s more, it’s not required for tumor development either.
Christy L. Trejo, Gidsela Luna, Christopher Dravis, Benjamin T. Spike, Geoffrey M. Wahl   +4 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Gene expression in chicken reveals correlation with structural genomic features and conserved patterns of transcription in the terrestrial vertebrates [PDF]

, 2010
The chicken is an important agricultural and avian-model species. A survey of gene expression in a range of different tissues will provide a benchmark for understanding expression levels under normal physiological conditions in birds.
Evert M van Schothorst, Aart Lammers, Lammers, Aart, Jack A. M. Leunissen, Neerincx, P., Jaap Keijer, Keijer, J., Jack A M Leunissen, Martien A M Groenen, Crooijmans Richard P. M. A., Neerincx Pieter B. T., Groenen Martien A. M., Richard P M A Crooijmans, van Schothorst, Evert M, Keijer, Jaap, Lammers, A., Keijer Jaap, Nie Haisheng, Pieter B. T. Neerincx, Megens, H.J.W.C., Neerincx, Pieter B T, Megens Hendrik-Jan, Schothorst, E.M., van, Pieter B T Neerincx, Martien A. M. Groenen, Nie, Haisheng, Groenen, M.A.M., Hendrik-Jan Megens, Richard P. M. A. Crooijmans, Leunissen, Jack A M, Crooijmans, Richard P M A, Groenen, Martien A M, van Schothorst Evert M., Nie, H., Megens, Hendrik-Jan, Crooijmans, R.P.M.A., Haisheng Nie, Lammers Aart, Leunissen, J.A.M., Evert M. van Schothorst, Leunissen Jack A. M.   +40 more
core   +2 more sources

SMRT regulation of nuclear receptors orchestrates bile acid homeostasis

Experimental and Molecular Medicine
Nuclear receptors are key effectors of metabolic programs; however, the contribution of co-regulatory complexes in maintaining metabolic homeostasis is not fully understood.
Kyeongkyu Kim, Sungsoon Fang, Suk-Hyun Hong, Han Cho, Mathias Leblanc, Sandra Jacinto, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Christopher Liddle, Morgan L. Truitt, Weiwei Fan, Chae Min Lee, Michael Downes, Ronald M. Evans   +14 more
doaj   +1 more source