Results 11 to 20 of about 3,742,529 (317)

Edge-weighting of gene expression graphs [PDF]

, 2009
In recent years, considerable research efforts have been directed to micro-array technologies and their role in providing simultaneous information on expression profiles for thousands of genes.
Kerr, Gráinne, Crane, Martin, DIMITRI PERRIN, HEATHER J. RUSKIN, Ruskin, Heather J., Perrin, Dimitri, MARTIN CRANE, GRAINNE KERR, Ruskin, Heather J   +8 more
core   +1 more source

Screening for coping style increases the power of gene expression studies [PDF]

, 2009
<b>Background:</b> Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges.
Pilarczyk, Maciej, Kadri, S., Davinia Morera Capdevila, Felicity A, Capdevila, Davinia Morera, Laia Ribas, Felicity A Huntingford, Huntingford, Felicity A, Simon MacKenzie, Ribas, L., MacKenzie, Simon, Sunil Kadri, Morera Capdevila, Davinia, Ribas, Laia, Pilarczyk, M., Morera, Davinia, MacKenzie, S., Huntingford, F.A., Maciej Pilarczyk, Kadri, Sunil, Capdevila, D.M., Huntingford, Felicity A., Ribas Cabezas, Laia   +22 more
core   +1 more source

Techniques for clustering gene expression data [PDF]

, 2008
Many clustering techniques have been proposed for the analysis of gene expression data obtained from microarray experiments. However, choice of suitable method(s) for a given experimental dataset is not straightforward. Common approaches do not translate
Kerr, Gráinne, Crane, Martin, M. Crane, H. J. Ruskin, Doolan, Padraig, Ruskin, Heather J., G. Kerr, P. Doolan   +7 more
core   +1 more source

A Brassica exon array for whole-transcript gene expression profiling [PDF]

, 2010
Affymetrix GeneChip® arrays are used widely to study transcriptional changes in response to developmental and environmental stimuli. GeneChip® arrays comprise multiple 25-mer oligonucleotide probes per gene and retain certain advantages over direct ...
King Graham J., Broadley, MR, May Sean T., John P. Hammond, Bowen, H. C., Bowen, HC, Hammond, J. P., Lochlainn, Seosamh O., Neil S Graham, Philip J White, Graham J. King, Broadley, Martin R., Ó Lochlainn Seosamh, May, ST, Hammond, John P., Graham, NS, Love Christopher G., Christopher G Love, Helen C. Bowen, Graham, N. S., Sean T. May, Philip J. White, Christopher G. Love, Graham, Neil S., O Lochlainn, S., Hammond John P., White, PJ, Graham J King, Ó Lochlainn, Seosamh, May, S. T., Hammond, JP, Love, Christopher G., Love, CG, Helen C Bowen, John P Hammond, Seosamh O Lochlainn, King, GJ, King, G. J., King, Graham J., Broadley, M. R., Broadley Martin R., May, Sean T., Bowen Helen C., Martin R. Broadley, Sean T May, Martin R Broadley, White, P. J., King , Graham J., Love, C. G., Neil S. Graham, White Philip J., White, Philip J., Graham Neil S., Lochlainn, SO, Bowen, Helen C.   +54 more
core   +1 more source

GC content of vertebrate exome landscapes reveal areas of accelerated protein evolution

BMC Evolutionary Biology, 2019
Background Rapid accumulation of vertebrate genome sequences render comparative genomics a powerful approach to study macro-evolutionary events. The assessment of phylogenic relationships between species routinely depends on the analysis of sequence ...
R. Huttener, L. Thorrez, T. in’t Veld, M. Granvik, L. Snoeck, L. Van Lommel, F. Schuit   +6 more
doaj   +1 more source

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Nature Communications, 2020
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma   +11 more
doaj   +1 more source

Python for gene expression [PDF]

F1000Research, 2021
Genome biology shows substantial progress in its analytical and computational part in the last decades. Differential gene expression is one of many computationally intense areas; it is largely developed under R programming language. Here we explain possible reasons for such dominance of R in gene expression data.
openaire   +3 more sources

Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly, Aki Endo, Alejandro Brenes, Marek Gierlinski, Vackar Afzal, Andrea Pawellek, Angus I. Lamond   +6 more
doaj   +1 more source

Idiotype vaccines produced with a non-cytopathic alphavirus self-amplifying RNA vector induce antitumor responses in a murine model of B-cell lymphoma

Scientific Reports, 2021
A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales, Eva Martisova, Helena Villanueva, Ascensión López Díaz de Cerio, Susana Inoges, Noelia Silva-Pilipich, María Cristina Ballesteros-Briones, Alejandro Aranda, Jaione Bezunartea, Maurizio Bendandi, Fernando Pastor, Cristian Smerdou   +11 more
doaj   +1 more source

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

Nature Communications, 2016
Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be ...
Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte   +22 more
doaj   +1 more source