Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
core +4 more sources
Folia Medica Indonesiana, 2021 This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java.
Mohamad Nurdin Zuhri +3 more
doaj +1 more source
Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro [PDF]
, 2019 Objective Aims were to investigate sensitivity of various human and canine cancer cell lines to hyperthermia and the influence of particular treatment conditions, and to analyze the DNA-damage response and mode of cell death in cell line radiosensitized
Nytko, Katarzina J. +4 more
core +2 more sources
Hsp70 gene association with nuclear speckles is Hsp70 promoter specific [PDF]
Journal of Cell Biology, 2010 Many mammalian genes localize near nuclear speckles, nuclear bodies enriched in ribonucleic acid–processing factors. In this paper, we dissect cis-elements required for nuclear speckle association of the heat shock protein 70 (Hsp70) locus. We show that speckle association is a general property of Hsp70 bacterial artificial chromosome transgenes ...
Hu, Yan, Plutz, Matt, Belmont, Andrew S.
openaire +2 more sources
Diagnostic Biomarkers of Heat Stress Induced- DNA in Occupational Exposure: A Systematic Review
بهداشت و ایمنی کار, 2022 Introduction: Climate change and hot processes in the workplaces has led to an increase in the effects of heat stress on employed people, which has become a major concern, especially in tropical and subtropical countries. Early detection of biomarkers in
Peymaneh Habibi +6 more
doaj
Association of heat shock protein 70 with motility of frozen-thawed sperm in bulls
Czech Journal of Animal Science, 2015 Heat shock protein 70 (HSP70) is considered as a gene which affects semen quality traits. The present study attempted to investigate the relationship between the HSP70 expression level and motility of bull sperm during the process of freezing-thawing ...
X.-G. Zhang +5 more
doaj +1 more source
Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]
, 2017 BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W +4 more
core +2 more sources
, 2021 Η πρωτεΐνη θερμικού σοκ Hsp70 (HSPA1A: heat shock πρωτεΐνη οικογένειας A (Hsp70) μέλος 1A) είναι η καλύτερα μελετημένη πρωτεΐνη στην οικογένεια A των Hsp70s. Πρόκειται για μια πρωτεΐνη επιβίωσης και πρωτεΐνη αντι-αποπτωτική, που σχετίζεται με πολλές ασθένειες στον άνθρωπο.
openaire +1 more source
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. [PDF]
, 2019 Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone.
Banduseela, Varuna C +19 more
core +2 more sources
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David +3 more
core +2 more sources