Results 1 to 10 of about 14,438 (137)

Ac-SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes. [PDF]

Animal Model Exp Med
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Guo W, Yan J, Li W, Wang J, Liu L, Zhang C, Cao W, Yao S, Gong H, He Y, Zhou Z, Chen S, Feng L, Deng H.   +13 more
europepmc   +2 more sources

Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches

Cells, 2022
Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant and is activated by heat shock, environmental stress, and pathophysiological stress. However, HSP27 dysregulation is a characteristic of many human cancers.
Sumira Malik, Saad Alkhtani
exaly   +3 more sources

Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model [PDF]

International Journal of Ophthalmology, 2020
AIM: To investigate the relationships between the changes of heat shock protein 27 antibody (anti-HSP27) in serum/cerebrospinal fluid (CSF), intraocular pressure (IOP), retinal ganglion cell (RGC) apoptosis in a rat glaucoma model and disclose the ...
Wei Zhao, Le Dai, Xiao-Ting Xi, Qian-Bo Chen, Mei-Xia An, Yan Li   +5 more
doaj   +1 more source

Role of HSP27 regulating RhoA in bladder smooth muscle remodeling in rats after bladder outlet obstruction

Di-san junyi daxue xuebao, 2021
Objective To explore the role and underlying mechanism of heat shock protein 27 (HSP27) in bladder smooth muscle remodeling after bladder outlet obstruction (BOO).
LIAO Deyang, WANG Yongquan, XIONG Zhiyong, ZHOU Xiaozhou, HE Peng, ZHOU Zhansong   +5 more
doaj   +1 more source

Heat Shock Protein 27(HSP27) in Kidney Disease: Potentials for Diagnosis and Therapy [PDF]

Journal of Advanced Pharmacy Research, 2017
The small HSP27 is an actin-specific molecular chaperone involved in cytoskeleton architecture, cell migration, metabolism, survival, growth/differentiation, mRNA stabilization, and tumor progression.
Shahenda Mahgoub
doaj   +1 more source

HSP27 Interacts with Nonstructural Proteins of Porcine Reproductive and Respiratory Syndrome Virus and Promotes Viral Replication

Pathogens, 2023
Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song, Hanze Liu, Zhi Cao, Hu Shan, Qiaoya Zhang   +4 more
doaj   +1 more source

HSP27 induced glaucomatous damage in mice of young and advanced age

Frontiers in Cellular Neuroscience, 2023
IntroductionAge-related diseases such as glaucoma, a leading cause of blindness, are having an upward trend due to an aging society. In glaucoma, some patients display altered antibody profiles and increased antibody titers, for example against heat ...
Clivia Erb, Sabrina Reinehr, Carsten Theiss, H. Burkhard Dick, Stephanie C. Joachim   +4 more
doaj   +1 more source

Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans [PDF]

PeerJ, 2020
Objectives This study set out to analyze the difference of heat shock protein 27 (HSP27) and its phosphorylation in patients with lower extremity arteriosclerosis obliterans (LEASO) at different stages.
Junqing Bai, Fule Wang, Xuguang Wang, Eerde Mutu, Chen Duan, Yili Qi, Liqiang Hu, Zhanfeng Gao   +7 more
doaj   +2 more sources

Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis

Cancer Cell International, 2023
Background Glioblastoma is one of the malignant tumors of the central nervous system with high lethality, high disability and low survival rate. Effective induction of its death is one of the existing challenges. In recent studies, heat shock protein 27 (
Kai Zhang, Yue Wu, Guangliang Chen, Hao Wang, Yongsheng Liu, Youxin Zhou   +5 more
doaj   +1 more source

Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases. [PDF]

PLoS ONE, 2015
Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat-shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases.
Thomas Schweiger, Christoph Nikolowsky, Patrick Starlinger, Denise Traxler, Matthias Zimmermann, Peter Birner, Balazs Hegedüs, Balazs Dome, Michael Bergmann, Michael Mildner, Walter Klepetko, Konrad Hoetzenecker, Hendrik Jan Ankersmit   +12 more
doaj   +1 more source