Results 1 to 10 of about 29,246 (248)

Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model [PDF]

Frontiers in Cellular Neuroscience
BackgroundCurrently, the treatment of glaucoma is limited to reducing intraocular pressure since other involved pathomechanisms are not well understood yet. Evidence points to an immune-mediated component in disease development.
Dominik L. Maler, Sabrina Reinehr, Leonie Deppe, H. Burkhard Dick, Stephanie C. Joachim   +4 more
doaj   +3 more sources

Hsp27-Actin Interaction [PDF]

Biochemistry Research International, 2011
Hsp27 oligomer is reported to interact with F-actin as a barbed-end-capping protein. The present study determined the binding strength and stoichiometry of the interaction using fluorescence of probes attached to Hsp27 cysteine-137.
Philip Graceffa
doaj   +3 more sources

HSP27 Interacts with Nonstructural Proteins of Porcine Reproductive and Respiratory Syndrome Virus and Promotes Viral Replication [PDF]

Pathogens, 2023
Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song, Hanze Liu, Zhi Cao, Hu Shan, Qiaoya Zhang   +4 more
doaj   +2 more sources

Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches

Cells, 2022
Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant and is activated by heat shock, environmental stress, and pathophysiological stress. However, HSP27 dysregulation is a characteristic of many human cancers.
Haruna Isiyaku Umar, Nobendu Mukerjee, Abdullahi Tunde Aborode   +2 more
exaly   +3 more sources

Proline isomerization in the C-terminal region of HSP27 [PDF]

Cell Stress and Chaperones, 2017
In mammals, small heat-shock proteins (sHSPs) typically assemble into interconverting, polydisperse oligomers. The dynamic exchange of sHSP oligomers is regulated, at least in part, by molecular interactions between the α-crystallin domain and the C-terminal region (CTR).
T. Reid Alderson, Justin L. P. Benesch, Andrew J. Baldwin   +2 more
openalex   +4 more sources

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

eLife, 2022
Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation.
Shengnan Zhang, Yi Zhu, Jinxia Lu, Zhenying Liu, Amanda G Lobato, Wen Zeng, Jiaqi Liu, Jiali Qiang, Shuyi Zeng, Yaoyang Zhang, Cong Liu, Jun Liu, Zhuohao He, R Grace Zhai, Dan Li   +14 more
doaj   +2 more sources

Biological Significance of Decreased HSP27 in Human Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Objective— Because culprit atherosclerotic plaques contain proteases, we hypothesized that the diminished heat shock protein 27 (HSP27) released by atherosclerotic plaques could be due to proteolysis. We assessed the role of HSP27 in human vascular smooth muscle cells (VSMCs) under proteolytic injury.
Jose Luis Martin-Ventura, Jean-Baptiste Michel, Olivier Meilhac   +2 more
exaly   +3 more sources

Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus [PDF]

Diabetology & Metabolic Syndrome
Background and aims Previous study found that interleukin 1β (IL-1β) is associated with diabetic cognitive dysfunction. Heat shock protein 27 (HSP27) is one of the factors related to IL-1β associated inflammation.
Shufang Yang, Haoqiang Zhang, Wenwen Zhu, Tong Niu, Huzaifa Fareeduddin Mohammed Farooqui, Jue Wang, Mingyue Yang, Enlin Liu, Shaohua Wang   +8 more
doaj   +2 more sources

Mispriming and PCR amplification of hsp27

Cell Stress & Chaperones, 1997
Franz Trautinger, Christian Jantschitsch, Robert Strohal, Mojgan Pourmojib, Ingela Kindås-Mügge   +4 more
openalex   +5 more sources

HSP27 functional switch drives castration-resistant prostate cancer via mTOR pathway activation, highlighting promising combination therapies. [PDF]

J Exp Clin Cancer Res
Duong QH, Le TK, Tran TT, Audebert S, Camoin L, Nguyen NG, Baboudjian M, Giusiano S, Phan UTT, Zaghdoudi S, Adelaide J, Baylot V, Gleave M, Garrido C, Taïeb D, Rocchi P.   +15 more
europepmc   +2 more sources