Results 21 to 30 of about 18,813 (211)

Expressions of HSP70 and HSP27 in Hepatocellular Carcinoma [PDF]

Journal of Korean Medical Science, 2005
The heat shock proteins (HSPs) are ubiquitous molecules induced in cells exposed to various stress conditions, including carcinogenesis. The HSP70 and HSP27 among HSPs are of special relevance in human cancer inhibiting apoptosis. The aim of this study is to investigate the expressions of HSP70 and HSP27 in hepatocellular carcinoma (HCC) in association
Mee Joo, Je G. Chi, Hyucksang Lee
openaire   +2 more sources

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids

Fly, 2017
Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal ...
Lorena De Mena, Deepak Chhangani, Pedro Fernandez-Funez, Diego E. Rincon-Limas   +3 more
doaj   +1 more source

Plasma Hsp27 and phosphorylated Hsp27 levels as biomarkers of cardiovascular disease

The FASEB Journal, 2013
Numerous clinical studies have investigated blood‐borne “biomarkers” that could be used to predict the risk of an acute coronary event in patients with atherosclerosis. Published studies have shown plasma levels of the stress‐response protein, Hsp27, decreased with age and decreased when atherosclerotic plaques were most complex and presumed to be less
William T. Gerthoffer, L. Tiara Muphy, Christopher Malozzi, Clara V. Massey   +3 more
openaire   +1 more source

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

eLife, 2022
Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation.
Shengnan Zhang, Yi Zhu, Jinxia Lu, Zhenying Liu, Amanda G Lobato, Wen Zeng, Jiaqi Liu, Jiali Qiang, Shuyi Zeng, Yaoyang Zhang, Cong Liu, Jun Liu, Zhuohao He, R Grace Zhai, Dan Li   +14 more
doaj   +1 more source

Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress*

European Journal of Medical Research, 2010
The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and pHSP27 were examined.
Muraoka R, Nakano K, Kurihara S, Yamada K, Kawakami T   +4 more
doaj   +1 more source

Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. [PDF]

PLoS ONE, 2013
Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(-/-) mice (apoE(-/-)HSP27(o/e)) - however, only in ...
Charles M Cuerrier, Yong-Xiang Chen, Dominique Tremblay, Katey Rayner, Melissa McNulty, XiaoLing Zhao, Christopher R J Kennedy, Jacqueline de BelleRoche, Andrew E Pelling, Edward R O'Brien   +9 more
doaj   +1 more source

Hsp27 Phosphorylation in Experimental Glaucoma

Investigative Opthalmology & Visual Science, 2007
The role of heat shock proteins (Hsp) in injury response has been well established, but it is now becoming apparent that the phosphorylation state of Hsp27 may be a critical determinant of its ability to act in a protective capacity. In this study, the expression of Hsp27 and its phosphorylation were evaluated in an experimental glaucoma model in Brown
Wei, Huang, John B, Fileta, Theodoros, Filippopoulos, Arjun, Ray, Adam, Dobberfuhl, Cynthia L, Grosskreutz   +5 more
openaire   +2 more sources

Upregulation of HSP27 in a Transgenic Model of ALS [PDF]

Journal of Neuropathology & Experimental Neurology, 2002
Mutations of the SOD1 gene underlie 1 form of familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known to induce heat shock proteins (HSPs).
Vicky, Vleminckx, Philip, Van Damme, Karolien, Goffin, Hans, Delye, Ludo, Van Den Bosch, Wim, Robberecht   +5 more
openaire   +2 more sources

Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress

Biomolecules, 2019
Heat shock protein 27 (HSP27) is a multifunctional protein that undergoes significant changes in its expression and phosphorylation in response to shear stress stimuli, suggesting that it may be involved in mechanotransduction.
Baohong Zhang, Fei Xie, Aziz ur Rehman Aziz, Shuai Shao, Wang Li, Sha Deng, Xiaoling Liao, Bo Liu   +7 more
doaj   +1 more source

Effects of upregulation of Hsp27 expression on oocyte development and maturation derived from polycystic ovary syndrome. [PDF]

PLoS ONE, 2013
Heat shock protein 27 (Hsp27) is a heat shock protein family member which can inhibit apoptosis. Our previous studies reported down-regulated Hsp27 in ovarian tissue derived from women with polycystic ovary syndrome (PCOS) however, the exact effect of ...
Lingbo Cai, Xiang Ma, Shan Liu, Jinjuan Liu, Wei Wang, Yugui Cui, Wei Ding, Yundong Mao, Huiping Chen, Jie Huang, Zuomin Zhou, Jiayin Liu   +11 more
doaj   +1 more source