Results 21 to 30 of about 7,287 (179)
International Journal on Biological Sciences, 2020 Lung squamous cell carcinoma (SCC) is one of the deadliest cancers both in China and worldwide. To date, the efficacy of lung SCC treatments is limited.
Yinan Yao +7 more
semanticscholar +1 more source
HEAT SHOCK PROTEIN 27 IN LARYNGEAL SQUAMOUS CELL CANCER TREATMENT
Сучасні медичні технології, 2020 Heat shock protein 27 (HSP27) belongs to a family of ATP-independent chaperones and plays a fundamental role in cell physiology in various disease states, including cancer. So, it was found that serum HSP27 levels were significantly increased in patients
O. V. Horolec +2 more
doaj +1 more source
Hsp27 reduces glycation‐induced toxicity and aggregation of alpha‐synuclein
The FASEB Journal, 2020 α‐synuclein (aSyn) is a major player in Parkinson's disease and a group of other disorders collectively known as synucleinopathies, but the precise molecular mechanisms involved are still unclear.
Hugo Vicente Miranda +5 more
semanticscholar +1 more source
Expressions of HSP70 and HSP27 in Hepatocellular Carcinoma [PDF]
Journal of Korean Medical Science, 2005 The heat shock proteins (HSPs) are ubiquitous molecules induced in cells exposed to various stress conditions, including carcinogenesis. The HSP70 and HSP27 among HSPs are of special relevance in human cancer inhibiting apoptosis. The aim of this study is to investigate the expressions of HSP70 and HSP27 in hepatocellular carcinoma (HCC) in association
Mee Joo, Je G. Chi, Hyucksang Lee
openaire +2 more sources
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression
Oncology Report, 2020 A previous proteomic screening of differentially expressed biomarkers between Kazakh patients with esophageal squamous cell carcinoma (ESCC) and normal adjacent tissues demonstrated that heat shock protein 27 (HSP27) and pyruvate kinase isoenzyme M2 ...
Xiao Zhang +8 more
semanticscholar +1 more source
secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids
Fly, 2017 Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal ...
Lorena De Mena +3 more
doaj +1 more source
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
Journal of Biomedical Science, 2023 Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We have developed a
Seulgi Jeon +8 more
doaj +1 more source
Aging, 2020 Bladder cancer (BC) is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes. High-mobility group nucleosome-binding domain 5 (HMGN5) is overexpressed in many cancers and could cause carcinogenesis in BC.
Kun Yao +6 more
semanticscholar +1 more source
Plasma Hsp27 and phosphorylated Hsp27 levels as biomarkers of cardiovascular disease
The FASEB Journal, 2013 Numerous clinical studies have investigated blood‐borne “biomarkers” that could be used to predict the risk of an acute coronary event in patients with atherosclerosis. Published studies have shown plasma levels of the stress‐response protein, Hsp27, decreased with age and decreased when atherosclerotic plaques were most complex and presumed to be less
William T. Gerthoffer +3 more
openaire +1 more source
Hsp27 Phosphorylation in Experimental Glaucoma
Investigative Opthalmology & Visual Science, 2007 The role of heat shock proteins (Hsp) in injury response has been well established, but it is now becoming apparent that the phosphorylation state of Hsp27 may be a critical determinant of its ability to act in a protective capacity. In this study, the expression of Hsp27 and its phosphorylation were evaluated in an experimental glaucoma model in Brown
Wei, Huang +5 more
openaire +2 more sources