Results 21 to 30 of about 29,265 (267)

Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases. [PDF]

PLoS ONE, 2015
Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat-shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases.
Thomas Schweiger, Christoph Nikolowsky, Patrick Starlinger, Denise Traxler, Matthias Zimmermann, Peter Birner, Balazs Hegedüs, Balazs Dome, Michael Bergmann, Michael Mildner, Walter Klepetko, Konrad Hoetzenecker, Hendrik Jan Ankersmit   +12 more
doaj   +1 more source

Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes [PDF]

, 2019
The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Dörner, Andrea, Hammer, Elke, Heger, Jacqueline, Landmesser, Ulf, Rauch, Ursula, Schultheiss, Heinz-Peter, Winter, Julia   +6 more
core   +2 more sources

Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]

, 2012
A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou, Daumantas Matulis, Egidijus Kazlauskas, Inga Čikotienė, Paul Workman, S. Mark Roe, Swee Y. Sharp, Wenqing Xu   +7 more
core   +12 more sources

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial. [PDF]

, 2017
Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer ...
Al-Hazzouri, Ahmed, Bendell, Johanna C, DeBusk, Laura M, Earwood, Chris, Guo, Shuangli, Ko, Andrew H, Lane, Cassie M, Murphy, Patrick B, Peyton, James D, Rodriguez, Francisco A, Shipley, Dianna L, Tempero, Margaret A, Waterhouse, David M, Womack, Mark S, Xiong, Henry Q   +14 more
core   +1 more source

HEAT SHOCK PROTEIN 27 IN LARYNGEAL SQUAMOUS CELL CANCER TREATMENT

Сучасні медичні технології, 2020
Heat shock protein 27 (HSP27) belongs to a family of ATP-independent chaperones and plays a fundamental role in cell physiology in various disease states, including cancer. So, it was found that serum HSP27 levels were significantly increased in patients
O. V. Horolec, V. A. Kashirin, L. L. Voroncova   +2 more
doaj   +1 more source

Expressions of HSP70 and HSP27 in Hepatocellular Carcinoma [PDF]

Journal of Korean Medical Science, 2005
The heat shock proteins (HSPs) are ubiquitous molecules induced in cells exposed to various stress conditions, including carcinogenesis. The HSP70 and HSP27 among HSPs are of special relevance in human cancer inhibiting apoptosis. The aim of this study is to investigate the expressions of HSP70 and HSP27 in hepatocellular carcinoma (HCC) in association
Mee Joo, Je G. Chi, Hyucksang Lee
openaire   +2 more sources

Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]

, 2015
Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A., Ecroyd, Heath, Meehan, Sarah, Treweek, Teresa M.   +3 more
core   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

Upregulation of HSP27 in a Transgenic Model of ALS [PDF]

Journal of Neuropathology & Experimental Neurology, 2002
Mutations of the SOD1 gene underlie 1 form of familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known to induce heat shock proteins (HSPs).
Vicky, Vleminckx, Philip, Van Damme, Karolien, Goffin, Hans, Delye, Ludo, Van Den Bosch, Wim, Robberecht   +5 more
openaire   +2 more sources