Results 1 to 10 of about 9,646 (179)

Therapeutic targets in diabetic peripheral neuropathy: heat shock proteins [PDF]

Frontiers in Endocrinology
Diabetic peripheral neuropathy (DPN), a debilitating diabetic complication, has a complex pathological mechanism involving oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress, and there are no effective disease-mitigating ...
Chengzhi Yin, Jiao Lv, Shujia Huang, Chenyu Lang, Yunyun Zhao, Guoqiang Wang, Junming Kan, Xiuge Wang   +7 more
doaj   +2 more sources

Honokiol Inhibits Colorectal Cancer Cell Growth: Involvement of Hsp27 as a Molecular Target [PDF]

Current Issues in Molecular Biology
Background/Objectives: Honokiol (HK), a bioactive phenolic compound, exhibits significant anti-cancer properties. This study aimed to investigate the anti-cancer effects of HK in colorectal cancer (CRC) cells by focusing on its direct interaction with ...
Youngbin Kim, Hyeon Du Jang, Da Hyeon An, Hyun Seo Lee, Hong-Gyum Kim, Sun Eun Choi   +5 more
doaj   +2 more sources

Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress [PDF]

Experimental Cell Research, 2007
During stress, the mammalian small heat shock protein Hsp27 enters cell nuclei. The present study examines the requirements for entry of Hsp27 into nuclei of normal rat kidney (NRK) renal epithelial cells, and for its interactions with specific nuclear structures.
Bryantsev, A.L, Chechenova, M.B, Shelden, E.A   +2 more
exaly   +4 more sources

The taming of small heat-shock proteins: crystallization of the α-crystallin domain from human Hsp27 [PDF]

Acta Crystallographica Section F: Structural Biology Communications, 2009
Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones. sHsps function as homooligomers or heterooligomers that are prone to subunit exchange and structural plasticity. Here, a procedure for obtaining diffraction-quality crystals of the alpha-crystallin domain of human Hsp27 is presented.
N B Gusev
exaly   +3 more sources

Comment on: Low expression of HSP27 and HSP70 predicts poor prognosis in laryngeal squamous cell carcinoma [PDF]

Journal of Cancer Research and Clinical Oncology
Borowczak et al. recently explored the prognostic role of heat shock proteins HSP27 and HSP70 in laryngeal squamous cell carcinoma (LSCC). Their study demonstrated that lower expression levels of these proteins were linked to significantly reduced ...
Doga Topkan, Efsun Somay, Erkan Topkan, Ugur Selek   +3 more
doaj   +2 more sources

The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system

International Journal of Hyperthermia, 2005
Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two heat shock proteins, the70 kDa Hsp (Hsp70) and the 27 kDa Hsp (Hsp27), is notable because both proteins are highly inducible in glial cells and neurons following a wide ...
Tamara Franklin, A -P Arrigo, R W Currie   +2 more
exaly   +4 more sources

HSP27 functional switch drives castration-resistant prostate cancer via mTOR pathway activation, highlighting promising combination therapies [PDF]

Journal of Experimental & Clinical Cancer Research
Background Castration-resistant prostate cancer (CRPC) is an advanced and ultimately incurable stage of the disease that arises despite androgen deprivation and remains challenging to treat due to the limited and short-lived efficacy of current therapies.
Quang Hieu Duong, Thi Khanh Le, Thi Thom Tran, Stéphane Audebert, Luc Camoin, Ngan Giang Nguyen, Michael Baboudjian, Sophie Giusiano, Uyen Thi Tu Phan, Souhaila Zaghdoudi, José Adelaide , Virginie Baylot, Martin Gleave, Carmen Garrido, David Taïeb, Palma Rocchi   +15 more
doaj   +2 more sources

Heat shock protein 27 (HSP27) in patients with ovarian cancer

Ginekologia Polska, 2021
Ovarian cancer remains a very common cause of death among women worldwide. The cause is to be found in too late of a diagnostic process and therapeutic difficulties The presence of heat shock proteins in the serum of ovarian cancer patients is still a new area of study. It is necessary to continue studies on the possibilities for using these markers to
Piotr Bodzek, Aleksandra Damasiewicz-Bodzek, Iwona Janosz, Łukasz Witek, Anita Olejek   +4 more
openaire   +3 more sources

HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5

Frontiers in Microbiology, 2021
Heat shock proteins (HSPs) are a protein family that respond to physiological stress, such as heat, starvation, and infection. As cellular protein chaperones, they play an important role in protein folding, assembly, and degradation.
Xiangrong Li, Ruixian Ma, Bei Wu, Yuhui Niu, Hongshan Li, Dianyu Li, Jingying Xie, Adi Idris, Ruofei Feng   +8 more
doaj   +1 more source

The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells. [PDF]

PLoS ONE, 2013
The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes.
Zohar Bromberg, Pierre Goloubinoff, Younousse Saidi, Yoram George Weiss   +3 more
doaj   +1 more source