Results 31 to 40 of about 9,646 (179)

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2011
The molecular mechanisms underlying the posttranslational modification of proteins in gastrointestinal cancer are still unknown. Here, we investigated the role of methylglyoxal modifications in gastrointestinal tumors. Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with ...
Oya-Ito, Tomoko, Naito, Yuji, Takagi, Tomohisa, Handa, Osamu, Matsui, Hirofumi, Yamada, Masaki, Shima, Keisuke, Yoshikawa, Toshikazu   +7 more
openaire   +2 more sources

HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection

Viruses, 2022
Pseudorabies (PR) is a domestic and wild animal infectious disease caused by the pseudorabies virus (PRV) and is one of the major infectious diseases that endanger the global swine industry.
Xiangrong Li, Jingying Xie, Dianyu Li, Hongshan Li, Yuhui Niu, Bei Wu, Yanmei Yang, Zhenfang Yan, Xiangbo Zhang, Lei Chen, Ruofei Feng   +10 more
doaj   +1 more source

Molecular Chaperones in Osteosarcoma: Diagnosis and Therapeutic Issues

Cells, 2021
Osteosarcoma (OS) is the most common form of primary bone tumor affecting mainly children and young adults. Despite therapeutic progress, the 5-year survival rate is 70%, but it drops drastically to 30% for poor responders to therapies or for patients ...
Morgane Lallier, Louise Marchandet, Brice Moukengue, Celine Charrier, Marc Baud’huin, Franck Verrecchia, Benjamin Ory, François Lamoureux   +7 more
doaj   +1 more source

Modulation of Heat-shock Protein 27 (Hsp27) Anti-apoptotic Activity by Methylglyoxal Modification [PDF]

Journal of Biological Chemistry, 2002
Methylglyoxal (MG) is one of the side-products in glycolysis, and it reacts with proteins under physiological conditions. Here, we identified heat-shock protein 27 (Hsp27) as a major MG-modified protein in cells. MG modification of Hsp27 selectively occurs at Arg-188 to form argpyrimidine, and mutation in the residue represses the formation of a large ...
Hiroshi, Sakamoto, Tetsuo, Mashima, Kazuo, Yamamoto, Takashi, Tsuruo   +3 more
openaire   +2 more sources

Functions and Therapeutic Use of Heat Shock Proteins in Hepatocellular Carcinoma

Livers
Heat shock proteins are intracellular proteins expressed in prokaryotes and eukaryotes that help protect the cell from stress. They play an important role in regulating cell cycle and cell death, work as molecular chaperons during the folding of newly ...
Ramakrushna Paul, Smriti Shreya, Shweta Pandey, Srishti Shriya, Aya Abou Hammoud, Christophe F. Grosset, Buddhi Prakash Jain   +6 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Expression of Heat Shock Protein-27 (Hsp27) and P38MAPK in Esophageal Squamous Cell Carcinoma [PDF]

Medical Science Monitor, 2017
BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a worldwide concern. This study looked at the relationship between the expression of differential proteins and the clinicopathological data and survival rate of ESCC patients to identify potential tumor markers for the growth and metastasis of ESCC.
Zhang, Yan, Feng, Zhiyin, Wang, Weina, Dong, Juanjuan, Gong, Xiaojin, Pu, Hongwei, Chen, Xiao   +6 more
openaire   +2 more sources

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

HEAT SHOCK PROTEIN 27 IS OVEREXPRESSED IN THE SKIN OF BITUMEN EXPOSED WORKERS. EARLY OBSERVATIONS

Journal of Biological Research, 2000
Heat Shock Proteins (HSPs) are chaperones involved in cellular defence mechanism against several different types of aggression. The HSP27 is a member of this family ( 1) . These molecules also participate in essential physiological processes, such as
C. Fenga, C. Loreto, C. Caltabiano, D. Germanò   +3 more
doaj   +1 more source

Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm

Antioxidants, 2023
Male infertility is a prevalent concern affecting couples worldwide. While genetic factors, hormonal imbalances, and reproductive system defects play significant roles, emerging evidence suggests that lifestyle choices also profoundly impact male ...
Magda Carvalho Henriques, Joana Santiago, António Patrício, Maria Teresa Herdeiro, Susana Loureiro, Margarida Fardilha   +5 more
doaj   +1 more source