Results 31 to 40 of about 3,351,166 (211)

Molecular mechanisms of heat shock proteins in distinct diseases [PDF]

, 2023
Heat shock proteins (HSPs) modulate the molecular mechanics of cells and cellular systems. Properly folded proteins are required for cellular processes and organisms use molecular mechanics to keep substrate proteins in their native state.
Abay, Cansu, Tutar, Merve, Niyazov, Laziz, Yürekli, Nazlıcan, Okat, Zehra, Tutar, Yusuf, Gök Yurttaş, Asiye, Açıkalın Coşkun, Kübra, Uçar Çifçi, Kezban, Al, Mervenur, Sağır, Fatma   +10 more
core  

Small heat shock protein Hsp27 is required for proper heart tube formation [PDF]

genesis, 2007
AbstractThe small heat shock protein Hsp27 has been shown to be involved in a diverse array of cellular processes, including cellular stress response, protein chaperone activity, regulation of cellular glutathione levels, apoptotic signaling, and regulation of actin polymerization and stability.
Daniel D, Brown, Kathleen S, Christine, Christopher, Showell, Frank L, Conlon   +3 more
openaire   +2 more sources

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2011
The molecular mechanisms underlying the posttranslational modification of proteins in gastrointestinal cancer are still unknown. Here, we investigated the role of methylglyoxal modifications in gastrointestinal tumors. Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with ...
Oya-Ito, Tomoko, Naito, Yuji, Takagi, Tomohisa, Handa, Osamu, Matsui, Hirofumi, Yamada, Masaki, Shima, Keisuke, Yoshikawa, Toshikazu   +7 more
openaire   +2 more sources

HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation. [PDF]

PLoS ONE, 2016
Heat shock proteins belong to a conserved protein family and are involved in multiple cellular processes. Heat shock protein 27 (Hsp27), also known as heat HSPB1, participates in cellular responses to not only heat shock, but also oxidative or chemical ...
Hongxing Ye, Hongguang Huang, Fei Cao, Mantao Chen, Xiujue Zheng, Renya Zhan   +5 more
doaj   +1 more source

Therapeutic Drugs and Natural Products: The Effect of Suppressing Heat Shock Proteins (Hsp) in Brain Tumors

, 2022
Brain tumors are common in the population, and approximately 17,000 new patients are diagnosed every year. Although there are advancements in conventional treatment, including surgery, radiotherapy and chemotherapy, they have limited effectiveness for ...
Onay-Ucar, Evren, Mertoglu, Elif, Kiyga, Ezgi, Sengelen, Aslihan   +3 more
core   +1 more source

HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection

Viruses, 2022
Pseudorabies (PR) is a domestic and wild animal infectious disease caused by the pseudorabies virus (PRV) and is one of the major infectious diseases that endanger the global swine industry.
Xiangrong Li, Jingying Xie, Dianyu Li, Hongshan Li, Yuhui Niu, Bei Wu, Yanmei Yang, Zhenfang Yan, Xiangbo Zhang, Lei Chen, Ruofei Feng   +10 more
doaj   +1 more source

Comparison of heat-shock responses between the hydrothermal vent shrimp Rimicaris exoculata and the related coastal shrimp Palaemonetes varians [PDF]

, 2010
The deep-sea vent shrimp Rimicaris exoculata is believed to occur at the hot end of the hydrothermal biotope in order to provide essential elements to its epibiosis. Because it is found close to hot venting water, R.
Thomas Chertemps, Sven Thatje, Shillito, Bruce, Leger, Nelly, Bruce Shillito, Nelly Léger, Chertemps, Thomas, Thatje, Sven, Ravaux, Juliette, Delphine Cottin, Cottin, Delphine, Juliette Ravaux   +11 more
core   +1 more source

Molecular Chaperones in Osteosarcoma: Diagnosis and Therapeutic Issues

Cells, 2021
Osteosarcoma (OS) is the most common form of primary bone tumor affecting mainly children and young adults. Despite therapeutic progress, the 5-year survival rate is 70%, but it drops drastically to 30% for poor responders to therapies or for patients ...
Morgane Lallier, Louise Marchandet, Brice Moukengue, Celine Charrier, Marc Baud’huin, Franck Verrecchia, Benjamin Ory, François Lamoureux   +7 more
doaj   +1 more source

Are IgG antibodies to heat shock proteins HSP27 and HSP60 useful markers in endometrial cancer and cervical cancer? [PDF]

, 2021
Objectives: Heat shock proteins are overexpressed in many human malignancies. The role of heat shock proteins as a therapeutic target in cancer as well as their association with drug resistance were widely documented.
Damasiewicz-Bodzek, Aleksandra; Department of Chemistry, Faculty of Medicine and Division of Dentistry, Medical University of Silesia, Zabrze, Poland, Witek, Lukasz; Department of Gynaecology, Obstetrics and Oncological Gynaecology, Faculty of Medical Sciences in Zabrze Medical University of Silesia, Bytom, Poland, Olejek, Anita; Department of Gynaecology, Obstetrics and Oncological Gynaecology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Bytom, Poland, Janosz, Iwona; Department of Gynaecology, Obstetrics and Oncological Gynaecology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Bytom, Poland, Bodzek, Piotr; Department of Gynaecology, Obstetrics and Oncological Gynaecology, Faculty of Medical Sciences in Zabrze Medical University of Silesia, Bytom, Poland, Szymala, Bogdan; Department of Gynaecology, Obstetrics and Oncological Gynaecology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Bytom, Poland   +5 more
core   +1 more source

Functions and Therapeutic Use of Heat Shock Proteins in Hepatocellular Carcinoma

Livers
Heat shock proteins are intracellular proteins expressed in prokaryotes and eukaryotes that help protect the cell from stress. They play an important role in regulating cell cycle and cell death, work as molecular chaperons during the folding of newly ...
Ramakrushna Paul, Smriti Shreya, Shweta Pandey, Srishti Shriya, Aya Abou Hammoud, Christophe F. Grosset, Buddhi Prakash Jain   +6 more
doaj   +1 more source