Results 21 to 30 of about 9,646 (179)

Molecular mechanisms of regulatory action of heat shock protein 27 kDa in the apoptosis of tumor cells

Бюллетень сибирской медицины, 2011
Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated.
Ye. V. Kaigorodova
doaj   +1 more source

The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

Cell Reports, 2023
Sphingolipids have key functions in membrane structure and cellular signaling. Ceramide is the central molecule of the sphingolipid metabolism and is generated by ceramide synthases (CerS) in the de novo pathway. Despite their critical function, mechanisms regulating CerS remain largely unknown.
Rowan A. Boyd, Saurav Majumder, Johnny Stiban, Grace Mavodza, Alexandra J. Straus, Sachin K. Kempelingaiah, Varun Reddy, Yusuf A. Hannun, Lina M. Obeid, Can E. Senkal   +9 more
openaire   +2 more sources

Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a  murine model of deep vein thrombosis

Scientific Reports, 2023
Heat shock proteins (HSPs) are molecular chaperones whose primary function is cytoprotection, supporting cell survival under (sub) lethal conditions.
Mizuho Nosaka, Yuko Ishida, Yumi Kuninaka, Akiko Ishigami, Akira Taruya, Emi Shimada, Yumiko Hashizume, Hiroki Yamamoto, Akihiko Kimura, Fukumi Furukawa, Toshikazu Kondo   +10 more
doaj   +1 more source

Association of miRNA and mRNA Levels of the Clinical Onset of Multiple Sclerosis Patients

Biology, 2021
Multiple sclerosis (MS) is a demyelinating disease characterized by chronic inflammation of the central nervous system, in which many factors can act together to influence disease susceptibility and progression.
Danuta Piotrzkowska, Elzbieta Miller, Ewa Kucharska, Marta Niwald, Ireneusz Majsterek   +4 more
doaj   +1 more source

Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivo

Neurobiology of Disease, 2006
Heat shock proteins (Hsps) are stress proteins that mediate protein stabilization in various tissues and protect cells from environmental stress. Novel evidence suggests that overexpression of the small heat shock protein 27 (Hsp27) in neurons protects ...
Alexandra Kretz, Christian Schmeer, Svetlana Tausch, Stefan Isenmann   +3 more
doaj   +1 more source

Small heat shock protein Hsp27 is required for proper heart tube formation [PDF]

genesis, 2007
AbstractThe small heat shock protein Hsp27 has been shown to be involved in a diverse array of cellular processes, including cellular stress response, protein chaperone activity, regulation of cellular glutathione levels, apoptotic signaling, and regulation of actin polymerization and stability.
Daniel D, Brown, Kathleen S, Christine, Christopher, Showell, Frank L, Conlon   +3 more
openaire   +2 more sources

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Nature Communications, 2018
Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.
Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A. Agard, Daniel R. Southworth, Koh Takeuchi, Jason E. Gestwicki   +8 more
doaj   +1 more source

Effects of transport stress on pathological injury and expression of main heat shock proteins in the caprine stomach

BMC Veterinary Research, 2020
Background Transportation is necessary to introduce new breeds of goats to the farm and move the adult meat goat from the farm to the slaughterhouse. However, these actions may give rise to transport stress.
Wei Hu, Tian Ye, Yanzhen Yang, Ben Liu, Wenya Zheng   +4 more
doaj   +1 more source

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

Neurobiology of Disease, 2008
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder, characterised by progressive motor neuron degeneration and muscle paralysis.
Paul S. Sharp, Mohammed T. Akbar, Sonia Bouri, Atsushi Senda, Kieran Joshi, Han-Jou Chen, David S. Latchman, Dominic J. Wells, Jacqueline de Belleroche   +8 more
doaj   +1 more source

HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation. [PDF]

PLoS ONE, 2016
Heat shock proteins belong to a conserved protein family and are involved in multiple cellular processes. Heat shock protein 27 (Hsp27), also known as heat HSPB1, participates in cellular responses to not only heat shock, but also oxidative or chemical ...
Hongxing Ye, Hongguang Huang, Fei Cao, Mantao Chen, Xiujue Zheng, Renya Zhan   +5 more
doaj   +1 more source