Results 41 to 50 of about 9,646 (179)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

A Diminish the chances of Mediterranean fruit fly Ceratitis capitata eggs surviving by suppressing the expression of the heat shock protein 27 gene (Hsp27).

Tikrit Journal for Agricultural Sciences
The hypothesized role of stress-inducible heat shock proteins is to act as a buffer against environmental variations and affect fitness in suboptimal conditions.
Farhan Al-Behadili, Qasim Ahmed, Thamer Al-Shuwaili, Beibei Li, Yonglin Ren   +4 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

In silico Characterization of Heat Shock Protein HSP27 in Mammals

World Journal of Biology and Biotechnology
Dairy animals have a significant role in every country’s agricultural economy. Livestock is the major sub-sector of the agricultural industry and the value of dairy products is increasing globally. Under pathological circumstances heat shock proteins (HSPs) promote protein repair, folding, refolding of misfolded peptides, and possible breakdown of ...
Samar Bano, Lubna Rasool, Abdue Rauf, Shabbir Hussain   +3 more
openaire   +1 more source

Ginkgo biloba extract decreases non-small cell lung cancer cell migration by downregulating metastasis-associated factor heat-shock protein 27.

PLoS ONE, 2014
Heat-shock proteins (HSPs) are molecular chaperones that protect proteins from damage. HSP27 expression is associated with cancer transformation and invasion.
Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Ming-Chan Yang, Yu-Jen Cheng, Jhi-Jhu Hwang, Wei-Hsian Yin, Inn-Wen Chong   +8 more
doaj   +1 more source

Alcohol consumption and cognitive function: A systematic review and dose–response meta‐analysis of 20 cohort studies

Addiction, EarlyView.
Abstract Background and aims Amid ongoing debate on whether low‐to‐moderate alcohol consumption reduces cardiovascular risk, studies examining the association between alcohol consumption and cognitive function have reported inconsistent results. To quantitatively assess this association, we conducted a dose–response meta‐analysis of cohort studies ...
Sooyeun Choi, Youjin Je
wiley   +1 more source

HSP22, a New Member of the Small Heat Shock Protein Superfamily, Interacts with Mimic of Phosphorylated HSP27 (3DHSP27) [PDF]

Journal of Biological Chemistry, 2001
Most of the members of the superfamily of mammalian small heat shock or stress proteins are abundant in muscles where they play a role in muscle function and maintenance of muscle integrity. One member of this protein superfamily, human HSP27, is rapidly phosphorylated on three serine residues (Ser(15), Ser(78), and Ser(82)) during cellular response to
R, Benndorf, X, Sun, R R, Gilmont, K J, Biederman, M P, Molloy, C W, Goodmurphy, H, Cheng, P C, Andrews, M J, Welsh   +8 more
openaire   +2 more sources

Therapeutic potential of Hsp27 in neurological diseases

Egyptian Journal of Medical Human Genetics, 2019
Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily.
Anila Venugopal, Kasthuri Sundaramoorthy, Balachandar Vellingiri   +2 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro [PDF]

Cell Stress and Chaperones, 2013
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease. The mechanism that underlies amyotrophic lateral sclerosis (ALS) pathology remains unclear, but protein inclusions are associated with all forms of the disease. Apart from pathogenic proteins, such as TDP-43 and SOD1, other proteins are associated with ALS inclusions including ...
Yerbury, Justin J, Gower, Dane, Vanags, Laura, Roberts, Kate, Lee, Jodi A, Ecroyd, Heath   +5 more
openaire   +3 more sources