Results 61 to 70 of about 3,351,166 (211)

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Bacterial Infection Elicits Heat Shock Protein 72 Release from Pleural Mesothelial Cells [PDF]

, 2013
Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro
Porcel, JM, Bielsa, S, Brown, JS, della Vergiliana, JFV, Temple, SEL, Waterer, GW, Lee, YCG, Lansley, SM, Creaney, J   +8 more
core  

Functional Characterization of the Small Heat Shock Protein Hsp12p from Candida albicans [PDF]

, 2012
Hsp12p is considered to be a small heat shock protein and conserved among fungal species. To investigate the expression of this heat shock protein in the fungal pathogen Candida albicans we developed an anti-CaHsp12p antibody.
Mühlschlegel, Fritz A., Fritz A. Mühlschlegel, De Sordi Luisa, Luisa De Sordi (146209), Fritz A. Mühlschlegel (146212), Fu Man-Shun, De Sordi, L, Fu, Man Shun, Fu, MS, Fritz A Mühlschlegel, Man-Shun Fu, Luisa De Sordi, Mühlschlegel Fritz A., De Sordi, Luisa, Mühlschlegel, FA, Luisa De Sordi¤b, Man-Shun Fu (146203)   +16 more
core   +1 more source

Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study [PDF]

, 2005
BACKGROUND AND PURPOSE: Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis.
XIAO, Q, Mandal, K, Willeit, J, Wick, G, Kiechl, S, Oberhollenzer, F, Schett, G, Mayr, M, XU, Q   +8 more
core   +5 more sources

Therapeutic potential of Hsp27 in neurological diseases

Egyptian Journal of Medical Human Genetics, 2019
Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily.
Anila Venugopal, Kasthuri Sundaramoorthy, Balachandar Vellingiri   +2 more
doaj   +1 more source

Alcohol consumption and cognitive function: A systematic review and dose–response meta‐analysis of 20 cohort studies

Addiction, EarlyView.
Abstract Background and aims Amid ongoing debate on whether low‐to‐moderate alcohol consumption reduces cardiovascular risk, studies examining the association between alcohol consumption and cognitive function have reported inconsistent results. To quantitatively assess this association, we conducted a dose–response meta‐analysis of cohort studies ...
Sooyeun Choi, Youjin Je
wiley   +1 more source

Calcium Homeostasis and Muscle Energy Metabolism Are Modified in HspB1-Null Mice

Proteomes, 2016
Hsp27—encoded by HspB1—is a member of the small heat shock proteins (sHsp, 12–43 kDa (kilodalton)) family. This protein is constitutively present in a wide variety of tissues and in many cell lines.
Brigitte Picard, Malek Kammoun, Mohammed Gagaoua, Christiane Barboiron, Bruno Meunier, Christophe Chambon, Isabelle Cassar-Malek   +6 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study

Experimental Physiology, EarlyView.
Abstract Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endurance and resistance responses, on muscle protein turnover following hindlimb unloading (HU) remain ...
Tom Normand‐Gravier, Robert Solsona, Christelle Bertrand‐Gaday, Margot Issertine, Florence Sabatier, Flavie Arnould, Sébastien Racinais, Fabio Borrani, Henri Bernardi, Anthony M. J. Sanchez   +9 more
wiley   +1 more source

HSP22, a New Member of the Small Heat Shock Protein Superfamily, Interacts with Mimic of Phosphorylated HSP27 (3DHSP27) [PDF]

Journal of Biological Chemistry, 2001
Most of the members of the superfamily of mammalian small heat shock or stress proteins are abundant in muscles where they play a role in muscle function and maintenance of muscle integrity. One member of this protein superfamily, human HSP27, is rapidly phosphorylated on three serine residues (Ser(15), Ser(78), and Ser(82)) during cellular response to
R, Benndorf, X, Sun, R R, Gilmont, K J, Biederman, M P, Molloy, C W, Goodmurphy, H, Cheng, P C, Andrews, M J, Welsh   +8 more
openaire   +2 more sources