Results 71 to 80 of about 9,646 (179)

Dual‐Function Lipid‐Based Nanovector Strategy for Glioblastoma Immunotherapy: STING Activation and M1 Microglia Polarization

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie, Mohamed Khaled Diab, Sherif Ashraf Fahmy   +2 more
wiley   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Ultraviolet B-Mediated Phosphorylation of the Small Heat Shock Protein HSP27 in Human Keratinocytes

Journal of Investigative Dermatology, 2000
Exposure of human keratinocytes to environmental stress is known to induce changes in the expression, phosphorylation, and subcellular relocalization of the 27 kDa heat shock protein. This study demonstrates that ultraviolet B (280-320 nM) irradiation with physiologic doses induces a dose-dependent phosphorylation of 27 kDa heat shock protein ...
Wong, Jon W., Shi, Biao, Farboud, Behnom, McClaren, Marla, Shibamoto, Takayuki, Cross, Carroll E., Isseroff, R. Rivkah   +6 more
openaire   +2 more sources

Proteomic Characterization of Annexin l (ANX1) and Heat Shock Protein 27 (HSP27) as Biomarkers for Invasive Hepatocellular Carcinoma Cells.

PLoS ONE, 2015
To search for reliable biomarkers and drug targets for management of hepatocellular carcinoma (HCC), we performed a global proteomic analysis of a pair of HCC cell lines with distinct differentiation statuses using 2-DE coupled with MALDI-TOF MS.
Ruo-Chiau Wang, Chien-Yu Huang, Tai-Long Pan, Wei-Yu Chen, Chun-Te Ho, Tsan-Zon Liu, Yu-Jia Chang   +6 more
doaj   +1 more source

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins

Cells, 2018
The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC.
Chien-Yu Huang, Po-Li Wei, Wei-Yu Chen, Wei-Chiao Chang, Yu-Jia Chang   +4 more
doaj   +1 more source

Mechanically Induced Skin Renewal: Evidence‐Based Insights Into Clinical, Structural and Inflammatory Changes Activated by Microneedling, Microdermabrasion and Microvibration

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Device‐based aesthetic procedures such as microneedling, microdermabrasion and microvibration have gained widespread clinical and institutional use for skin rejuvenation, yet the underlying biological mechanisms and the robustness of clinical evidence remain incompletely established.
Arielle Springer, Elena Helfenbein, Jürgen Blaak   +2 more
wiley   +1 more source

Role of Heat-Shock Proteins in the Determination of Postmortem Metabolism and Meat Quality Development of DFD Meat

Foods
This research explored the potential role of various heat-shock proteins (HSPs) in the determination of postmortem metabolism and the development of meat quality of normal, atypical DFD, and typical DFD beef. Beef longissimus thoracis muscle samples were
Muawuz Ijaz, Xin Li, Chengli Hou, Zubair Hussain, Dequan Zhang   +4 more
doaj   +1 more source

Changes in HSP gene and protein expression in natural scrapie with brain damage

Veterinary Research, 2011
Heat shock proteins (Hsp) perform cytoprotective functions such as apoptosis regulation and inflammatory response control. These proteins can also be secreted to the extracellular medium, acting as inflammatory mediators, and their chaperone activity ...
Serrano Carmen, Bolea Rosa, Lyahyai Jaber, Filali Hicham, Varona Luis, Marcos-Carcavilla Ane, Acín Cristina, Calvo Jorge H, Serrano Magdalena, Badiola Juan J, Zaragoza Pilar, Martín-Burriel Inmaculada   +11 more
doaj   +1 more source

Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.

PLoS ONE, 2012
A high percentage of oesophageal adenocarcinomas show an aggressive clinical behaviour with a significant resistance to chemotherapy. Heat-shock proteins (HSPs) and glucose-regulated proteins (GRPs) are molecular chaperones that play an important role in
Julia Slotta-Huspenina, Daniela Berg, Karina Bauer, Claudia Wolff, Katharina Malinowsky, Lukas Bauer, Enken Drecoll, Marcus Bettstetter, Marcus Feith, Axel Walch, Heinz Höfler, Karl-Friedrich Becker, Rupert Langer   +12 more
doaj   +1 more source

Heat Shock Protein Expression Independently Predicts Survival Outcome in Schistosomiasis-Associated Urinary Bladder Cancer

The International Journal of Biological Markers, 2008
Background Heat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. These molecules have been studied in several malignancies, among which bladder carcinoma.
A. EL-Meghawry El-Kenawy Phd, A.F. El-kott, M.S. Hasan   +2 more
doaj   +1 more source