Results 11 to 20 of about 3,351,166 (211)
The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro [PDF]
Cell Stress and Chaperones, 2013 Amyotrophic lateral sclerosis is a devastating neurodegenerative disease. The mechanism that underlies amyotrophic lateral sclerosis (ALS) pathology remains unclear, but protein inclusions are associated with all forms of the disease. Apart from pathogenic proteins, such as TDP-43 and SOD1, other proteins are associated with ALS inclusions including ...
Yerbury, Justin J +5 more
core +5 more sources
Heat shock protein 27 (HSP27) in patients with ovarian cancer
Ginekologia Polska, 2021 Ovarian cancer remains a very common cause of death among women worldwide. The cause is to be found in too late of a diagnostic process and therapeutic difficulties The presence of heat shock proteins in the serum of ovarian cancer patients is still a new area of study. It is necessary to continue studies on the possibilities for using these markers to
Piotr Bodzek +4 more
openaire +3 more sources
The Role of Hsp27 in Chemotherapy Resistance
Biomedicines, 2022 Heat shock protein (Hsp)-27 is a small-sized, ATP-independent, chaperone molecule that is overexpressed under conditions of cellular stress such as oxidative stress and heat shock, and protects proteins from unfolding, thus facilitating proteostasis and ...
Marios Lampros +3 more
doaj +1 more source
p53-dependent induction of heat shock protein 27 (HSP27) expression [PDF]
International Journal of Cancer, 2000 Transcriptional activation of the p53 target genes plays a critical role in the cellular response to DNA damage, hypoxia, cellular stress and other signals regulating the cell cycle and apoptosis. The discovery of new p53 target genes continues to reveal novel mechanisms of action of this multifaceted protein.
C, Gao +5 more
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2023 Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a variety of cellular stress states. It is involved in regulating proteostasis and protecting cells from multiple sources of stress injury by stabilizing protein ...
Yifei Zou +5 more
doaj +1 more source
Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target [PDF]
Fibrogenesis & Tissue Repair, 2012 Abstract Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles ...
Vidyasagar, Aparna +2 more
openaire +2 more sources
Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. [PDF]
PLoS ONE, 2012 Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate.
Benjamin Gibert +10 more
doaj +1 more source
The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation
Cell Reports, 2023 Sphingolipids have key functions in membrane structure and cellular signaling. Ceramide is the central molecule of the sphingolipid metabolism and is generated by ceramide synthases (CerS) in the de novo pathway. Despite their critical function, mechanisms regulating CerS remain largely unknown.
Rowan A. Boyd +9 more
openaire +2 more sources
Heat shock proteins in tendinopathy: novel molecular regulators [PDF]
, 2012 Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar +3 more
core +1 more source
Frontiers in Immunology, 2016 Heat shock protein 27 (HSP27) is traditionally viewed as an intra-cellular chaperone protein with anti-apoptotic properties. However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extra-cellular space ...
Zarah Batulan +7 more
doaj +1 more source