Results 11 to 20 of about 9,646 (179)
Heat Shock Protein 27 Affects Myeloid Cell Activation and Interaction with Prostate Cancer Cells
Biomedicines, 2022 Heat shock proteins are cytoprotective molecules induced by environmental stresses. The small heat shock protein 27 (Hsp27) is highly expressed under oxidative stress conditions, mediating anti-oxidative effects and blocking apoptosis.
Debora Singer +3 more
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Pathogens, 2023 Heat shock protein 27 (HSP27) is a multifunctional protein and belongs to the small HSP family. It has been shown that HSP27 is involved in viral replication as a cellular chaperone, but the function of HSP27 during porcine reproductive and respiratory ...
Chunhui Song +4 more
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The Role of Hsp27 in Chemotherapy Resistance
Biomedicines, 2022 Heat shock protein (Hsp)-27 is a small-sized, ATP-independent, chaperone molecule that is overexpressed under conditions of cellular stress such as oxidative stress and heat shock, and protects proteins from unfolding, thus facilitating proteostasis and ...
Marios Lampros +3 more
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p53-dependent induction of heat shock protein 27 (HSP27) expression [PDF]
International Journal of Cancer, 2000 Transcriptional activation of the p53 target genes plays a critical role in the cellular response to DNA damage, hypoxia, cellular stress and other signals regulating the cell cycle and apoptosis. The discovery of new p53 target genes continues to reveal novel mechanisms of action of this multifaceted protein.
C, Gao +5 more
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Frontiers in Cardiovascular Medicine, 2023 Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a variety of cellular stress states. It is involved in regulating proteostasis and protecting cells from multiple sources of stress injury by stabilizing protein ...
Yifei Zou +5 more
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Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]
Cancer, 2003 AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry, Lebret +6 more
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Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target [PDF]
Fibrogenesis & Tissue Repair, 2012 Abstract Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles ...
Vidyasagar, Aparna +2 more
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Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. [PDF]
PLoS ONE, 2012 Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate.
Benjamin Gibert +10 more
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Frontiers in Immunology, 2016 Heat shock protein 27 (HSP27) is traditionally viewed as an intra-cellular chaperone protein with anti-apoptotic properties. However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extra-cellular space ...
Zarah Batulan +7 more
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Localization and expression of Hsp27 and αB-crystallin in rat primary myocardial cells during heat stress in vitro. [PDF]
PLoS ONE, 2013 Neonatal rat primary myocardial cells were subjected to heat stress in vitro, as a model for investigating the distribution and expression of Hsp27 and αB-crystallin.
Shu Tang +7 more
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