Results 31 to 40 of about 7,287 (179)

Upregulation of HSP27 in a Transgenic Model of ALS [PDF]

Journal of Neuropathology & Experimental Neurology, 2002
Mutations of the SOD1 gene underlie 1 form of familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known to induce heat shock proteins (HSPs).
Vicky, Vleminckx, Philip, Van Damme, Karolien, Goffin, Hans, Delye, Ludo, Van Den Bosch, Wim, Robberecht   +5 more
openaire   +2 more sources

Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress*

European Journal of Medical Research, 2010
The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and pHSP27 were examined.
Muraoka R, Nakano K, Kurihara S, Yamada K, Kawakami T   +4 more
doaj   +1 more source

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

eLife, 2022
Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation.
Shengnan Zhang, Yi Zhu, Jinxia Lu, Zhenying Liu, Amanda G Lobato, Wen Zeng, Jiaqi Liu, Jiali Qiang, Shuyi Zeng, Yaoyang Zhang, Cong Liu, Jun Liu, Zhuohao He, R Grace Zhai, Dan Li   +14 more
doaj   +1 more source

Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress

Biomolecules, 2019
Heat shock protein 27 (HSP27) is a multifunctional protein that undergoes significant changes in its expression and phosphorylation in response to shear stress stimuli, suggesting that it may be involved in mechanotransduction.
Baohong Zhang, Fei Xie, Aziz ur Rehman Aziz, Shuai Shao, Wang Li, Sha Deng, Xiaoling Liao, Bo Liu   +7 more
doaj   +1 more source

Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models.

Journal of Clinical Investigation, 2019
HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structure-guided ...
L. Nappi, A. Aguda, N. A. Nakouzi, Barbara Lelj-Garolla, E. Beraldi, N. Lallous, Marisa Thi, Susan Moore, L. Fazli, Dulguun Battsogt, Sophie M. Stief, Fuqiang Ban, N. Nguyen, N. Saxena, Evgenia V. Dueva, Fan Zhang, Takeshi Yamazaki, A. Zoubeidi, A. Cherkasov, G. Brayer, M. Gleave   +20 more
semanticscholar   +1 more source

A Role for HSP27 in Sensory Neuron Survival [PDF]

The Journal of Neuroscience, 1999
Peripheral nerve injury in neonatal rats results in the death of the majority of the axotomized sensory neurons by 7 d after injury. In adult animals, however, all sensory neurons survive for at least 4 months after axotomy. How sensory neurons acquire the capacity to survive axonal injury is not known.
S E, Lewis, R J, Mannion, F A, White, R E, Coggeshall, S, Beggs, M, Costigan, J L, Martin, W H, Dillmann, C J, Woolf   +8 more
openaire   +2 more sources

Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. [PDF]

PLoS ONE, 2013
Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(-/-) mice (apoE(-/-)HSP27(o/e)) - however, only in ...
Charles M Cuerrier, Yong-Xiang Chen, Dominique Tremblay, Katey Rayner, Melissa McNulty, XiaoLing Zhao, Christopher R J Kennedy, Jacqueline de BelleRoche, Andrew E Pelling, Edward R O'Brien   +9 more
doaj   +1 more source

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

Journal of Biological Chemistry, 2018
Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock proteins (sHsps),
Dezerae Cox, Daniel R. Whiten, James W. P. Brown, M. Horrocks, Rebecca San Gil, C. Dobson, D. Klenerman, A. V. van Oijen, H. Ecroyd   +8 more
semanticscholar   +1 more source

Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules

Oncotarget, 2016
Heat shock protein 27 (HSP27, HSPB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. The biochemical properties of HSP27 rely on a structural oligomeric and dynamic organization that is important for its chaperone activity.
Kim, Jee Hye, Jung, Ye Jin, Choi, Byeol, Lee, Na Lim, Lee, Hae Jun, Kwak, Soo Yeon, Kwon, Youngjoo, Na, Younghwa, Lee, Yun-Sil   +8 more
openaire   +3 more sources

Serum heat shock protein 27 levels predict cardiac mortality in hemodialysis patients

BMC Nephrology, 2018
Background Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors ...
Andrzej Jaroszyński, Anna Jaroszyńska, Tomasz Zaborowski, Anna Drelich-Zbroja, Tomasz Zapolski, Wojciech Dąbrowski   +5 more
doaj   +1 more source