secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids
Fly, 2017 Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal ...
Lorena De Mena +3 more
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Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. [PDF]
PLoS ONE, 2013 Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(-/-) mice (apoE(-/-)HSP27(o/e)) - however, only in ...
Charles M Cuerrier +9 more
doaj +1 more source
Serum Hsp70 antigen: Early diagnosis marker in perinatal asphyxia [PDF]
, 2015 BACKGROUND: Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate ...
Boskabadi, Hassan +6 more
core +1 more source
Plasma Hsp27 and phosphorylated Hsp27 levels as biomarkers of cardiovascular disease
The FASEB Journal, 2013 Numerous clinical studies have investigated blood‐borne “biomarkers” that could be used to predict the risk of an acute coronary event in patients with atherosclerosis. Published studies have shown plasma levels of the stress‐response protein, Hsp27, decreased with age and decreased when atherosclerotic plaques were most complex and presumed to be less
William T. Gerthoffer +3 more
openaire +1 more source
A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]
, 2013 BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C. +6 more
core +3 more sources
Hsp27 Phosphorylation in Experimental Glaucoma
Investigative Opthalmology & Visual Science, 2007 The role of heat shock proteins (Hsp) in injury response has been well established, but it is now becoming apparent that the phosphorylation state of Hsp27 may be a critical determinant of its ability to act in a protective capacity. In this study, the expression of Hsp27 and its phosphorylation were evaluated in an experimental glaucoma model in Brown
Wei, Huang +5 more
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Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress
Biomolecules, 2019 Heat shock protein 27 (HSP27) is a multifunctional protein that undergoes significant changes in its expression and phosphorylation in response to shear stress stimuli, suggesting that it may be involved in mechanotransduction.
Baohong Zhang +7 more
doaj +1 more source
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. [PDF]
, 2018 Small heat shock proteins (sHSPs) are a class of oligomeric molecular chaperones that limit protein aggregation. However, it is often not clear where sHSPs bind on their client proteins or how these protein-protein interactions (PPIs) are regulated. Here,
Agard, David A +8 more
core +2 more sources
Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
core +4 more sources
European Journal of Medical Research, 2010 The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and pHSP27 were examined.
Muraoka R +4 more
doaj +1 more source