Results 41 to 50 of about 18,813 (211)
EGb761 and HSP27-siRNA transfection effect on the expression of HSP27 in A549/H441.
, 2014 (A) The HSP27 mRNA expression of A549/H441 cells was decreased with EGb761 treatment or HSP27-siRNA transfection 24 hours later as compared to control group. (B) The HSP27 protein expression of A549/H441 cells was also decreased with EGb761 treatment and
Wei-Hsian Yin (174686) +8 more
core +1 more source
Viruses, 2022 Pseudorabies (PR) is a domestic and wild animal infectious disease caused by the pseudorabies virus (PRV) and is one of the major infectious diseases that endanger the global swine industry.
Xiangrong Li +10 more
doaj +1 more source
Lead Optimization of Dual Tubulin and Hsp27 Inhibitors [PDF]
, 2014 Tubulin and heat shock protein 27 (Hsp27) are well-characterized molecular targets for anti-cancer drug development. We previously identified lead compounds that inhibited both Hsp27 and tubulin. These compounds exhibited extensive anti-cancer activities
Lama, Rati +4 more
core +2 more sources
Romanian Journal of Laboratory Medicine, 2019 Background: Heat shock protein 27 (HSP27) is an intracellular chaperone constitutively expressed in many cell types including cardio myocytes and endothelial cells. Circulating levels of HSP27 and anti-HSP27 antibody are higher in patients with CVD. Anti-
Sadabadi Fatemeh +20 more
doaj +1 more source
Sensitization of lung cancer cells by altered dimerization of HSP27
, 2021 Heat shock protein 27 (HSP27, HSPB1) induces resistance to anticancer drugs in various cancer types, including non-small cell lung cancer (NSCLC). Therefore, pharmacological inhibition of HSP27 in NSCLC may be a good strategy for anticancer therapy ...
이윤실, 이화정, 권영주
core +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma
BMC Cancer, 2009 Background Recent proteomic studies identified Hsp27 as a highly over-expressed protein in oral squamous cell carcinoma (OSCC). Clinical studies that attempted to evaluate the prognostic values of Hsp27 yielded inconsistent results, which may be due to ...
Peng Tingsheng +7 more
doaj +1 more source
BMEMat, EarlyView.The effects of matrix dynamics on cancer progression remain unclear. Herein, we fabricated a tunable dynamic hydrogel via reversible host–guest crosslinking and demonstrated that high matrix dynamics activate Piezo1 and its downstream PI3K/AKT and Wnt/β‐catenin signaling pathways, thereby enhancing cancer spheroid assembly, elevating cancer stemness ...
Yi Liu +9 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley +1 more source
DPCs target Hsp27 for neuroprotection in vitro.
, 2013 Significantly elevated levels of Hsp27 expression were detected in OGD-exposed primary rat neural cells co-cultured with DPCs, which was most pronounced in GFAP-positive cells showing dose-dependent expression of Hsp27 ...
Yuji Kaneko (106226) +7 more
core +1 more source