Results 41 to 50 of about 29,265 (267)
A Role for HSP27 in Sensory Neuron Survival [PDF]
The Journal of Neuroscience, 1999 Peripheral nerve injury in neonatal rats results in the death of the majority of the axotomized sensory neurons by 7 d after injury. In adult animals, however, all sensory neurons survive for at least 4 months after axotomy. How sensory neurons acquire the capacity to survive axonal injury is not known.
S E, Lewis +8 more
openaire +2 more sources
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
Journal of Biomedical Science, 2023 Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We have developed a
Seulgi Jeon +8 more
doaj +1 more source
Spaceflight modulates gene expression in the whole blood of astronauts [PDF]
, 2016 Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases.
Barrila, Jennifer +7 more
core +2 more sources
Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease [PDF]
, 2014 Low protein levels of Hsp27 have been reported in atherosclerotic plaques. In addition, human studies have indicated that circulating Hsp27 levels are lower in coronary artery disease patients compared with controls.
Andre M van Rij +4 more
core +1 more source
Serum heat shock protein 27 levels predict cardiac mortality in hemodialysis patients
BMC Nephrology, 2018 Background Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors ...
Andrzej Jaroszyński +5 more
doaj +1 more source
Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes [PDF]
, 2007 In the present study, we have investigated the effect of the chemical CDK-inhibitor CYC202 on E6 and E7-transformed keratinocytes, in which the function of the cellular cell cycle inhibitor p21Cip1 is abrogated by the viral genes.
Atanasova, Ganka +4 more
core +2 more sources
Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules
Oncotarget, 2016 Heat shock protein 27 (HSP27, HSPB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. The biochemical properties of HSP27 rely on a structural oligomeric and dynamic organization that is important for its chaperone activity.
Kim, Jee Hye +8 more
openaire +3 more sources
Cells, 2018 The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC.
Chien-Yu Huang +4 more
doaj +1 more source
Frontiers in Microbiology, 2021 Heat shock proteins (HSPs) are a protein family that respond to physiological stress, such as heat, starvation, and infection. As cellular protein chaperones, they play an important role in protein folding, assembly, and degradation.
Xiangrong Li +8 more
doaj +1 more source
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma
BMC Cancer, 2009 Background Recent proteomic studies identified Hsp27 as a highly over-expressed protein in oral squamous cell carcinoma (OSCC). Clinical studies that attempted to evaluate the prognostic values of Hsp27 yielded inconsistent results, which may be due to ...
Peng Tingsheng +7 more
doaj +1 more source