Results 61 to 70 of about 18,813 (211)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Hsp27 as a Negative Regulator of Cytochrome c Release [PDF]

Molecular and Cellular Biology, 2002
We previously showed that Hsp27 protects against apoptosis through its interaction with cytosolic cytochrome c. We have revisited this protective activity in murine cell lines expressing different levels of Hsp27. We report that Hsp27 also interferes, in a manner dependent on level of expression, with the release of cytochrome c from mitochondria ...
Paul, C., Manero, F., Gonin, S., Kretz-Remy, C., Virot, S., Arrigo, A.P.   +5 more
openaire   +5 more sources

WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer

Cancer Science, EarlyView.
WDR12 promotes glucose metabolism and tumor growth in GC. Mechanistically, WDR12 interacts with TDP43 and appears to enhance PFKFB4 expression, thereby promoting glucose metabolism. ABSTRACT Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely ...
Rutong Zhang, Dehua Liu, Xiaoxi Feng, Aoxing Cheng, Zhenye Yang, Kaiguang Zhang   +5 more
wiley   +1 more source

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study

Experimental Physiology, EarlyView.
Abstract Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endurance and resistance responses, on muscle protein turnover following hindlimb unloading (HU) remain ...
Tom Normand‐Gravier, Robert Solsona, Christelle Bertrand‐Gaday, Margot Issertine, Florence Sabatier, Flavie Arnould, Sébastien Racinais, Fabio Borrani, Henri Bernardi, Anthony M. J. Sanchez   +9 more
wiley   +1 more source

Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

BMC Cancer, 2009
Background During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis.
Sun Lu, Li Yan, Kang Nan, Guo Kun, Gan Lin, Cui Feng, Gao Mei, Liu Kun   +7 more
doaj   +1 more source

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

Does Hsp27 protect cortical neurons against amyloid?

, 2009
Neurofibrillary tangles (NFTs) and plaques are considered to be hallmarks of Alzheimer's disease (AD), although it is still not clear whether these aggregates contribute to disease progress or whether they might even play an initial protective role.
King, Michael T. C. (Michael Thomas Cecil)
core   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

, 2007
Huntington's disease (HD) is caused by an expanded polyglutamine tract in the huntingtin protein. Mitochondrial dysfunction and free radical damage occur in both R6/2 mice and HD patient brains and might play a role in disease pathogenesis.
Kristiansen, M, Bates, G P, Morimoto, R I, Gidalevitz, T, Zourlidou, A, Latchman, D S, Landles, C, Wells, D J, Tabrizi, S J, Woodman, B, de Belleroche, J   +10 more
core   +1 more source

Prevalence of anti-Hsp27 antibodies and their relation to antisperm antibodies in infertile patients [PDF]

Pharmacia
Serum antibodies against the small heat shock protein Hsp27 (HspB1) have been associated with certain diseases but have not been studied in infertility.
Katerina Kavaldzhieva, Dimitrina Dimitrova-Dikanarova, Anton Kolarov, Desislav Dinev, Vladislav Lazarov, Nikola Mladenov   +5 more
doaj   +3 more sources