Results 81 to 90 of about 18,813 (211)

HSP27: A Therapeutic Target in Myelofibrosis

Blood, 2016
Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive bone marrow fibrosis resulting into bone marrow failure. JAK2 kinase inhibitors have been successfully used for a few years in MPN and more particularly for MF ...
Margaux Sevin, Nicolas Pernet, Franck Vitte, Selim Ramla, Paul Sagot, Laurent Martin, Jean Luc Villeval, Catherine Lacout, Isabelle Plo, Carmen Garrido, Francois Girodon, Aurelie de Thonel   +11 more
openaire   +1 more source

Expression and function of the small heat shock protein Hsp27 during embryogenesis of zebrafish Danio rerio [PDF]

, 2007
The expression of the small heat shock protein 27 (Hsp27) is increased in response to diverse stress conditions. During early embryogenesis of mammals, including humans, Hsp27 is also constitutively expressed in skeletal and cardiac muscles.
Ustyugov, Alexey
core   +3 more sources

Anti-HSP27 antibody and dephosphorylation inhibit hHSP27 neuroprotective effects.

, 2013
A, Infarct volumes in control, hHSP27 (50 µg), hHSP27 plus HSP27 antibody cocktails, HSP27 elution peptide, recombinant HSP27, and dephosphorylated hHSP27 groups.
Takao Urabe (421323), Nobukazu Miyamoto (421321), Shinichiro Teramoto (421318), Hideki Shimura (421319), Hajime Arai (421322), Yoshiaki Shimada (421320), Nobutaka Hattori (180398), Ryota Tanaka (296836)   +7 more
core   +1 more source

Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila

Journal of Biomedical Science, 2012
Background Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulation of neurodegeneration and ...
Chen Shih-Fen, Kang Ming-Lun, Chen Yi-Chun, Tang Hong-Wen, Huang Cheng-Wen, Li Wan-Hua, Lin Chun-Pu, Wang Chao-Yung, Wang Pei-Yu, Chen Guang-Chao, Wang Horng-Dar   +10 more
doaj   +1 more source

Hsp27 and Hsp90 expression analysis.

, 2013
(A) Quantification of realtime PCR expression analysis of Hsp27 and Hsp90 mRNAs in controls, ω-6 and ω-3 fatty acids pre-treated hTM normalized to controls.
Friedrich E. Kruse (283318), Ulrich-Christoph Welge-Lüssen (333748), Kerstin Birke (298730), Theofilos Tourtas (333746), Marco T. Birke (333747)   +4 more
core   +1 more source

Immunoblot analyses of the unphosphorylated and phosphorylated forms of HSP27.

, 2012
Cytosolic proteins (20 µg) isolated from the left ventricular myocardium of control (C), morphine-treated (M), and morphine-withdrawn for 3 days (MW-I) or 6 days (MW-II) rats were separated on 15% polyacrylamide gels by SDS-PAGE and electrotransferred ...
Jitka Skrabalova (128781), Frantisek Kolar (128789), Petr Jedelsky (128784), Zdenka Drastichova (128778), Jan Neckar (128786), Jiri Novotny (128791)   +5 more
core   +1 more source

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

Frontiers in Immunology, 2016
Heat shock protein 27 (HSP27) is traditionally viewed as an intra-cellular chaperone protein with anti-apoptotic properties. However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extra-cellular space ...
Zarah Batulan, Vivek Krishna Pulakazhi Venu, Yumei Li, Yumei Li, Geremy Koumbadinga, Daiana Gisela Alvarez-Olmedo, Chunhua Shi, Edward R. O'Brien   +7 more
doaj   +1 more source

Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells

, 2015
Gemcitabine has been used most commonly as an anticancer drug to treat advanced pancreatic cancer patients. However, intrinsic or acquired resistance of pancreatic cancer to gemcitabine was also developed, which leads to very low five-year survival rates.
김주항, 송재진, 최혜진
core   +1 more source

The relationship between individual levels of HSP27 phosphorylation (Ser-78) in the platelets and the released phosphorylated HSP27 levels induced by collagen in type 2 DM patients.

, 2015
The baseline levels in unstimulated samples were subtracted from each of the individual HSP27 phosphorylation ratio (phosphorylated-HSP27/total HSP27) and phosphorylated HSP27 levels in the conditioned mixture after platelet aggregation stimulated by 0.3
Rie Matsushima-Nishiwaki (480791), Kumiko Tanabe (750228), Takanobu Otsuka (579057), Osamu Kozawa (480798), Yukiko Enomoto (750224), Haruhiko Tokuda (750221), Akiko Kojima (750226), Hiroki Iida (750230), Toru Iwama (359134), Kei Ishikawa (750233), Tomoaki Doi (750227), Shigeru Akamatsu (750229), Masanori Tsujimoto (750223), Takahisa Tanikawa (750232), Shinji Ogura (750231), Takashi Onuma (750225), Kumi Kojima (750234), Gen Kuroyanagi (750222)   +17 more
core   +1 more source

Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection

Emerging Microbes and Infections
A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus replication after entry.
Mandi Wu, Qianya Wan, Xuelian Dan, Yiran Wang, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming-Liang He   +8 more
doaj   +1 more source