Results 81 to 90 of about 29,265 (267)

Supplementary Figure Legends 1-5 from Hsp27 Modulates p53 Signaling and Suppresses Cellular Senescence [PDF]

, 2023
Cornelia O’Callaghan-Sunol, Vladimir L. Gabai, Michael Y. Sherman   +2 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Evaluating the expression of heat shock protein 27 and topoisomerase II α in a retrospective cohort of patients diagnosed with locally advanced breast cancer and treated with neoadjuvant anthracycline-based chemotherapies

Frontiers in Oncology, 2023
BackgroundNeoadjuvant anthracycline-based chemotherapy (NAC) is a major regimen for the treatment of local advanced breast cancer (LABC), while resistance to NAC remains a paramount clinical obstacle.
Yixuan Zhuang, Yixuan Zhuang, Fan Zhang, Yue Xu, Lifang He, Wenhe Huang, Chaoqun Hong, Yukun Cui   +7 more
doaj   +1 more source

Heat shock protein 27 is a potential indicator for response to YangZheng XiaoJi and chemotherapy agents in cancer cells [PDF]

, 2016
Heat shock protein 27 (HSP27) is a member of the heat shock protein family which has been linked to tumour progression and, most interestingly, to chemotherapy resistance in cancer patients.
Dart, Alwyn, Gao, Yong, Jiang, Wen Guo, Owen, Sioned, Ruge, Fiona, Wang, Yamei, Wei, Cong, Wu, Yiling, Zhao, Huishan   +8 more
core   +2 more sources

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

BMC Cancer, 2009
Background During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis.
Sun Lu, Li Yan, Kang Nan, Guo Kun, Gan Lin, Cui Feng, Gao Mei, Liu Kun   +7 more
doaj   +1 more source

Polymorphisms of Bovine HSP90 and Their Implications in Beef Cattle Productivity [PDF]

, 2018
Production of beef cattle represents a $60 billion industry in the United States (USDA, 2015). The American beef cattle industry loses an estimated $370 million annually due to heat stress (St-Pierre, 2003).
Smith, Glynn G
core   +2 more sources

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1 [PDF]

, 2013
BACKGROUND We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases.
A Filipovic, AA Adjei, AJ Levine, B Vogelstein, C-Y Koo, CH Shen, CL Brooks, D Zhang, DP Xirodimas, DR Rhodes, F De Amicis, F Vikhanskaya, G Giamas, G Giamas, H Mi, H Vaziri, H Zhang, H Zhang, HR Xing, J Cox, J Cox, J Hu, J Lozano, J Stebbing, J Yuan, JA Goettel, JE Kim, JR Wisniewski, K Kornfeld, L C Lit, L Zannini, M Therrien, M Therrien, M Zafrullah, MN Laurent, R Brough, R Fujita, R Kolesnick, RL Kortum, S Matsuoka, T Rajakulendran, TE Thingholm, V Nin, W Zhao, WM Abida, Y Tang, Y Xu, Y Zhang   +47 more
core   +2 more sources

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source