Results 91 to 100 of about 29,265 (267)
Cellular & Molecular Biology Letters, 2017 Background Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of oxidative stress in vascular ...
Sili Zou +6 more
doaj +1 more source
Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer. [PDF]
, 2017 Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including ...
Anderson, Kelsey N. +10 more
core +1 more source
Drug Development Research, Volume 87, Issue 3, May 2026.ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie +2 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2010 Background Heat shock protein 27 (Hsp27), a member of the small heat shock protein family, is an apoptosis regulator. Our previous proteomic study showed that Hsp27 mainly expressed in human oocyte, and that Hsp27 expression was downregulated in the ...
Cai Ling-Bo +4 more
doaj +1 more source
HSP27: A Therapeutic Target in Myelofibrosis
Blood, 2016 Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive bone marrow fibrosis resulting into bone marrow failure. JAK2 kinase inhibitors have been successfully used for a few years in MPN and more particularly for MF ...
Margaux Sevin +11 more
openaire +1 more source
Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities
MedComm, Volume 7, Issue 5, May 2026.This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng +8 more
wiley +1 more source
Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) [PDF]
, 2015 Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1.
Baillie, George, Sin, Yuan Yan
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.ABSTRACT Glioblastoma (GBM) is an aggressive brain tumour with an immunosuppressive environment and poor prognosis; however, the roles of mitophagy and oxidative stress in its prognosis remain underexplored. This study analysed multi‐omics data from TCGA‐GBM (n = 168) and two GEO cohorts (GSE43378, n = 50; GSE147352, n = 85), compiling 603 mitophagy ...
Changjiang He +2 more
wiley +1 more source
Heat shock proteins as potential biomarkers of heart failure
Кардиоваскулярная терапия и профилактикаThe number of patients with heart failure (HF) has increased markedly over the past decades and continues to increase. During pathological cardiac remodeling in HF, vicious cycles of cellular stress are triggered.
Yu. S. Timofeev +5 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Heat stress impairs livestock performance through oxidative stress, immune dysregulation, and reduced productivity. Phytobiotics act as natural mitigators with antioxidant, anti‐inflammatory, antimicrobial, and gut‐modulatory effects. Mechanistically, they regulate HSPs, Nrf2, NF‐κB, and MAPK pathways.
Xiaoyan Wang +4 more
wiley +1 more source