Results 91 to 100 of about 7,287 (179)

HSP27: A Therapeutic Target in Myelofibrosis

Blood, 2016
Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive bone marrow fibrosis resulting into bone marrow failure. JAK2 kinase inhibitors have been successfully used for a few years in MPN and more particularly for MF ...
Margaux Sevin, Nicolas Pernet, Franck Vitte, Selim Ramla, Paul Sagot, Laurent Martin, Jean Luc Villeval, Catherine Lacout, Isabelle Plo, Carmen Garrido, Francois Girodon, Aurelie de Thonel   +11 more
openaire   +1 more source

Prevalence of anti-Hsp27 antibodies and their relation to antisperm antibodies in infertile patients [PDF]

Pharmacia
Serum antibodies against the small heat shock protein Hsp27 (HspB1) have been associated with certain diseases but have not been studied in infertility.
Katerina Kavaldzhieva, Dimitrina Dimitrova-Dikanarova, Anton Kolarov, Desislav Dinev, Vladislav Lazarov, Nikola Mladenov   +5 more
doaj   +3 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Heat Shock Protein HSP27 Secretion by Ovarian Cancer Cells Is Linked to Intracellular Expression Levels, Occurs Independently of the Endoplasmic Reticulum Pathway and HSP27's Phosphorylation Status, and Is Mediated by Exosome Liberation

Disease Markers, 2017
The heat shock protein HSP27 has been correlated in ovarian cancer (OC) patients with aggressiveness and chemoresistance and, therefore, represents a promising potential biomarker for OC diagnosis, prognosis, and treatment response. Notably, secretion of
M. Stope, Gerd Klinkmann, K. Diesing, D. Koensgen, M. Burchardt, A. Mustea   +5 more
semanticscholar   +1 more source

Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila

Journal of Biomedical Science, 2012
Background Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulation of neurodegeneration and ...
Chen Shih-Fen, Kang Ming-Lun, Chen Yi-Chun, Tang Hong-Wen, Huang Cheng-Wen, Li Wan-Hua, Lin Chun-Pu, Wang Chao-Yung, Wang Pei-Yu, Chen Guang-Chao, Wang Horng-Dar   +10 more
doaj   +1 more source

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Nature Communications, 2018
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions.
Margaux Sevin, L. Kubovcakova, N. Pernet, Sebastien Z. Causse, F. Vitte, J. Villeval, C. Lacout, Marine Cordonnier, F. Rodrigues-Lima, Gaëtan Chanteloup, M. Mosca, M. Chrétien, J. Bastie, S. Audia, P. Sagot, Selim Ramla, Laurent Martin, M. Gleave, V. Mezger, R. Skoda, I. Plo, C. Garrido, F. Girodon, A. de Thonel   +23 more
semanticscholar   +1 more source

Heat shock proteins as potential biomarkers of heart failure

Кардиоваскулярная терапия и профилактика
The number of patients with heart failure (HF) has increased markedly over the past decades and continues to increase. During pathological cardiac remodeling in HF, vicious cycles of cellular stress are triggered.
Yu. S. Timofeev, A. A. Afaunova, V. A. Metelskaya, A. A. Ivanova, O. N. Dzhioeva, O. M. Drapkina   +5 more
doaj   +1 more source

Interaction of serum heat shock proteins’ levels with the severity of venous congestion in patients with acute decompensated heart failure with preserved ejection fraction

Кардиоваскулярная терапия и профилактика
Aim. To analyze the interactions between heat shock proteins (HSPs) (HSP27, HSP70 and cardiovascular HSP — cvHSP) serum levels and acute decompensated heart failure (HF) and signs of venous congestion in patients with preserved ejection fraction (HFpEF ...
Yu. S. Timofeev, A. R. Afaunova, A. A. Ivanova, T. Yu. Vedenikin, O. N. Dzhioeva, V. A. Metelskaya, M. S. Pokrovskaya, O. M. Drapkina   +7 more
doaj   +1 more source

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

Medicine Science
Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell-cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to ...
Badel Arslan, Nurcan Aras, Selma Yaman, Ulku Comelekoglu   +3 more
doaj   +1 more source

Dual Silencing of Hsp27 and c-FLIP Enhances Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells

The Scientific World Journal, 2013
We evaluated effect of dual gene silencing of Hsp27 and c-FLIP in doxazosin-induced apoptosis of PC-3 cell. After transfection using Hsp27 and c-FLIP siRNA mixture (dual silencing), doxazosin treatment was done at the concentrations of 1, 10, and 25 μM ...
Sang Soo Kim, Hee-Ju Cho, Jeong-Man Cho, Jung Yoon Kang, Hyun-Won Yang, Tag Keun Yoo   +5 more
doaj   +1 more source