Results 71 to 80 of about 18,813 (211)

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

The relationship between individual levels of HSP27 phosphorylation (Ser-78) and the change of intracellular HSP27 protein levels induced by collagen in platelets from type 2 DM patients.

, 2015
The baseline levels in unstimulated samples were subtracted from each of the individual HSP27 phosphorylation ratio (phosphorylated-HSP27/total HSP27) and intracellular HSP27 protein levels stimulated by 0.3 μg/ml of collagen for 4 min, and the net ...
Rie Matsushima-Nishiwaki (480791), Kumiko Tanabe (750228), Takanobu Otsuka (579057), Osamu Kozawa (480798), Yukiko Enomoto (750224), Haruhiko Tokuda (750221), Akiko Kojima (750226), Hiroki Iida (750230), Toru Iwama (359134), Kei Ishikawa (750233), Tomoaki Doi (750227), Shigeru Akamatsu (750229), Masanori Tsujimoto (750223), Takahisa Tanikawa (750232), Shinji Ogura (750231), Takashi Onuma (750225), Kumi Kojima (750234), Gen Kuroyanagi (750222)   +17 more
core   +1 more source

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

Medicine Science
Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell-cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to ...
Badel Arslan, Nurcan Aras, Selma Yaman, Ulku Comelekoglu   +3 more
doaj   +1 more source

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

Protein Science, Volume 35, Issue 10, October 2026.
Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes, Maria K. Janowska, Lisa M. Tuttle, Miklos Guttman, Abhinav Nath, Rachel E. Klevit   +5 more
wiley   +1 more source

Heat shock proteins as potential biomarkers of heart failure

Кардиоваскулярная терапия и профилактика
The number of patients with heart failure (HF) has increased markedly over the past decades and continues to increase. During pathological cardiac remodeling in HF, vicious cycles of cellular stress are triggered.
Yu. S. Timofeev, A. A. Afaunova, V. A. Metelskaya, A. A. Ivanova, O. N. Dzhioeva, O. M. Drapkina   +5 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, Volume 13, Issue 54, 28 September 2026.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Strong upregulation of HSP27 in lung tissues from IPF patients.

, 2016
(A) Immunohistochemical staining of HSP27 in human lung tissues. Representative images are shown (n = 5). (B) Double immunofluorescence staining of HSP27 (green) and α-SMA (red) in human lung tissues. Representative images are shown (n = 4).
Ah-Mee Park (849064), Kouji Matsushima (26883), Kyosuke Kanai (849065), Tatsuya Tsukui (849067), Moises Selman (3449249), Takao Sato (146959), Yutaka Inagaki (844333), Tatsuki Itoh (849066), Osamu Yoshie (68444)   +8 more
core   +1 more source

Interaction of serum heat shock proteins’ levels with the severity of venous congestion in patients with acute decompensated heart failure with preserved ejection fraction

Кардиоваскулярная терапия и профилактика
Aim. To analyze the interactions between heat shock proteins (HSPs) (HSP27, HSP70 and cardiovascular HSP — cvHSP) serum levels and acute decompensated heart failure (HF) and signs of venous congestion in patients with preserved ejection fraction (HFpEF ...
Yu. S. Timofeev, A. R. Afaunova, A. A. Ivanova, T. Yu. Vedenikin, O. N. Dzhioeva, V. A. Metelskaya, M. S. Pokrovskaya, O. M. Drapkina   +7 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Dual Silencing of Hsp27 and c-FLIP Enhances Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells

The Scientific World Journal, 2013
We evaluated effect of dual gene silencing of Hsp27 and c-FLIP in doxazosin-induced apoptosis of PC-3 cell. After transfection using Hsp27 and c-FLIP siRNA mixture (dual silencing), doxazosin treatment was done at the concentrations of 1, 10, and 25 μM ...
Sang Soo Kim, Hee-Ju Cho, Jeong-Man Cho, Jung Yoon Kang, Hyun-Won Yang, Tag Keun Yoo   +5 more
doaj   +1 more source