Results 51 to 60 of about 18,813 (211)
Cellular & Molecular Biology Letters, 2017 Background Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of oxidative stress in vascular ...
Sili Zou +6 more
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Frontiers in Oncology, 2023 ObjectiveTo investigate the effect of Hsp27 and the inhibitory effect of Atractylenolide I (ATL-1) on the proliferation of prostate cancer cell DU145 and PC-3.MethodsMTT assay was used to detect the inhibitory effect of silencing Hsp27 and ATL-1 on DU145
Pengfei Qiao, Zhentao Tian
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The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
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Сибирский онкологический журнал, 2016 New and original values (coefficient of phosphorylation and coefficient of intracellular distribution) proposed. They are reflecting a functional state of the heat shock protein 27 kDa (Hsp27) in tumor cells of breast cancer.
E. V. Kaigorodova +7 more
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Reproductive Biology and Endocrinology, 2010 Background Heat shock protein 27 (Hsp27), a member of the small heat shock protein family, is an apoptosis regulator. Our previous proteomic study showed that Hsp27 mainly expressed in human oocyte, and that Hsp27 expression was downregulated in the ...
Cai Ling-Bo +4 more
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Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Inhibition of HSP27 alleviates Pulmonary Fibrosis
, 2020 Part 1. Radiation-induced pulmonary fibrosis (RIPF) is the main side effect after thoracic irradiation for lung cancer, however, the protective strategies and the underlying mechanisms remain to be investigated. The expression of heat shock protein 27 (
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Addiction, EarlyView.Abstract Background and aims Amid ongoing debate on whether low‐to‐moderate alcohol consumption reduces cardiovascular risk, studies examining the association between alcohol consumption and cognitive function have reported inconsistent results. To quantitatively assess this association, we conducted a dose–response meta‐analysis of cohort studies ...
Sooyeun Choi, Youjin Je
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Knockdown of HSP27 expression levels suppressed cell migration.
, 2015 HSP27 expression levels were knocked down by transfection with HSP27-specific shRNA into SK-Hep–1 cells as described in the Methods and Materials. (A) The expression levels of HSP27 in control and HSP27-KD cells were determined by real-time PCR and ...
Yu-Jia Chang (143398) +6 more
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Plasma, 2022 Heat shock protein 27 (Hsp27) is a cytoprotective molecule and is inducible via oxidative stress. Anti-cancer therapies, such as the recently investigated gas plasma, subject tumor cells to a plethora of reactive oxygen species (ROS).
Debora Singer +3 more
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