Results 51 to 60 of about 7,287 (179)

Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers

Pharmaceutics, 2021
Relationships between heat shock protein 27 (HSP27) and cancer aggressiveness, metastasis, drug resistance, and poor patient outcomes in various cancer types including non-small cell lung cancer (NSCLC) were reported, and inhibition of HSP27 expression ...
Hawon Yoo, Seul-Ki Choi, Jaeok Lee, So Hyeon Park, You Na Park, Soo-Yeon Hwang, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Hwa Jeong Lee, Yun-Sil Lee   +10 more
doaj   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Local unfolding of the HSP27 monomer regulates chaperone activity

Nature Communications, 2018
The small heat-shock protein HSP27 is a redox-sensitive molecular chaperone that is expressed throughout the human body. Here, we describe redox-induced changes to the structure, dynamics, and function of HSP27 and its conserved α-crystallin domain (ACD).
T. R. Alderson, Julien Roche, Heidi Y. Gastall, David M. Dias, I. Pritišanac, Jinfa Ying, A. Bax, J. Benesch, Andrew J. Baldwin   +8 more
semanticscholar   +1 more source

HSP27 and cell survival in neurones

International Journal of Hyperthermia, 2005
Although the majority of studies on the protective effect of individual hsps have concentrated on the major inducible heat shock protein Hsp70, a variety of evidence suggests that the small heat shock protein Hsp27 may have a more potent protective effect in the nervous system.
openaire   +2 more sources

Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study

Romanian Journal of Laboratory Medicine, 2019
Background: Heat shock protein 27 (HSP27) is an intracellular chaperone constitutively expressed in many cell types including cardio myocytes and endothelial cells. Circulating levels of HSP27 and anti-HSP27 antibody are higher in patients with CVD. Anti-
Sadabadi Fatemeh, Heidari-Bakavoli Alireza, Esmaily Habibollah, Darroudi Susan, Tayefi Maryam, Asadi Zahra, Parizadeh Seyed Mohammad Reza, Tavalaie Shima, malekzadeh Najmeh, Moghaddam Kiana Hosseinpour, Moghadam Azam Rastgar, Sahebkar Amir Hosein, Fereydouni Narges, Barati Elham, Azarpazhooh Mahmoudreza, Hosseini Seyyed Javad, Tayyebi Mohammad, Ebrahimi Mahmoud, Ferns Gordon A., Ghayour-Mobarhan Majid, Mouhebati Mohsen   +20 more
doaj   +1 more source

Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation.

Oncology Report, 2019
Redd1 is a stress response protein that functions as a repressor of mTORC1, a central regulator of protein translation, resulting in the inhibition of cell growth and metabolism. However, paradoxically, high Redd1 expression favors cancer progression and
Hyeon-Ok Jin, Sung-Eun Hong, Ji-Young Kim, Mi-Ri Kim, Yoon Hwan Chang, Y. Hong, Jin Kyung Lee, I. Park   +7 more
semanticscholar   +1 more source

Quantitative Immunomorphological Analysis of Heat Shock Proteins in Thyroid Follicular Adenoma and Carcinoma Tissues Reveals Their Potential for Differential Diagnosis and Points to a Role in Carcinogenesis

Applied Sciences, 2019
Hsp27, Hsp60, Hsp70, and Hsp90 are chaperones that play a crucial role in cellular homeostasis and differentiation, but they may be implicated in carcinogenesis. Follicular neoplasms of the thyroid include follicular adenoma and follicular carcinoma. The
Alessandro Pitruzzella, Letizia Paladino, Alessandra Maria Vitale, Stefania Martorana, Calogero Cipolla, Giuseppa Graceffa, Daniela Cabibi, Sabrina David, Alberto Fucarino, Fabio Bucchieri, Francesco Cappello, Everly Conway de Macario, Alberto JL Macario, Francesca Rappa   +13 more
doaj   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Atractylenolide I inhibits EMT and enhances the antitumor effect of cabozantinib in prostate cancer via targeting Hsp27

Frontiers in Oncology, 2023
ObjectiveTo investigate the effect of Hsp27 and the inhibitory effect of Atractylenolide I (ATL-1) on the proliferation of prostate cancer cell DU145 and PC-3.MethodsMTT assay was used to detect the inhibitory effect of silencing Hsp27 and ATL-1 on DU145
Pengfei Qiao, Zhentao Tian
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source