Results 101 to 110 of about 29,265 (267)

Interaction of serum heat shock proteins’ levels with the severity of venous congestion in patients with acute decompensated heart failure with preserved ejection fraction

Кардиоваскулярная терапия и профилактика
Aim. To analyze the interactions between heat shock proteins (HSPs) (HSP27, HSP70 and cardiovascular HSP — cvHSP) serum levels and acute decompensated heart failure (HF) and signs of venous congestion in patients with preserved ejection fraction (HFpEF ...
Yu. S. Timofeev, A. R. Afaunova, A. A. Ivanova, T. Yu. Vedenikin, O. N. Dzhioeva, V. A. Metelskaya, M. S. Pokrovskaya, O. M. Drapkina   +7 more
doaj   +1 more source

Dual Silencing of Hsp27 and c-FLIP Enhances Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells

The Scientific World Journal, 2013
We evaluated effect of dual gene silencing of Hsp27 and c-FLIP in doxazosin-induced apoptosis of PC-3 cell. After transfection using Hsp27 and c-FLIP siRNA mixture (dual silencing), doxazosin treatment was done at the concentrations of 1, 10, and 25 μM ...
Sang Soo Kim, Hee-Ju Cho, Jeong-Man Cho, Jung Yoon Kang, Hyun-Won Yang, Tag Keun Yoo   +5 more
doaj   +1 more source

Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27 [PDF]

, 2013
10.1038/cddis.2013.413Cell Death and ...
A Ashkenazi, A Kulisz, AM Joy, AM Ramos, AP Arrigo, AP Arrigo, AP Arrigo, CG Concannon, D Stokoe, D Stokoe, DR Ciocca, E Berrou, EA Nollen, G Zauli, H Lambert, H Walczak, H Zhuang, HN LeBlanc, J Cairns, J Jakubowicz-Gil, J Kim, J Kim, J Rouse, J Saklatvala, JK Larsen, JM Bruey, JM Bruey, JW Wong, K Ohnishi, K Shenoy, M Alvarado-Kristensson, M Clayer, M McClaren, M Zhou, MJ Borrelli, P Kaur, P Mehlen, R Cuesta, R Koschny, R Regazzi, RK Hansen, RK Rao, RL Whisler, RM Pitti, SJ Charette, SJ Cok, SK Calderwood, SR Wiley, T Naka, T Rogalla, TC Chou, TW Poh, U Jakob, WJ Welch   +53 more
core   +2 more sources

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

Medicine Science
Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell-cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to ...
Badel Arslan, Nurcan Aras, Selma Yaman, Ulku Comelekoglu   +3 more
doaj   +1 more source

Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]

, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F., Conway De Macario E., Macario A. J. L., Marino Gammazza A., Scalia F.   +4 more
core   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock [PDF]

, 2014
Background: MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation of actin cytoskeleton dynamics ...
Brouckaert, Peter, Cauwels, Anje, Goethals, An, Simats, Alba, Van Hamme, Evelien, Vandendriessche, Benjamin   +5 more
core   +1 more source

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain

Protein Science, Volume 35, Issue 4, April 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) is a nucleic acid‐binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C‐terminal low‐complexity domain (TDP‐43LCD). TDP‐43 aggregation and condensation are associated with neurodegenerative disease.
Thomas B. Walker, Joshua W. Trowbridge, Shannon McMahon, Nicholas R. Marzano, Lauren Rice, Justin J. Yerbury, Heath Ecroyd, Luke McAlary   +7 more
wiley   +1 more source

The effect of extra virgin olive oil on HSP27 expression in the cerebral cortex of male Rattus norvegicus middle cerebral artery occlusion model

Food & Nutrition Research
Background: Ischemic stroke produces oxidative stress in neurons and neuroglial, triggering a cellular response with HSP27 as one of the markers. Extra virgin olive oil (EVOO) is reported to act as a neuroprotection by inhibiting reactive oxygen species,
Abdulloh Machin, Viskasari Pintoko Kalanjati, Anisa Nur’aini Abidah, Paulus Sugianto, Joni Susanto, Azizah Amimathul Firdha   +5 more
doaj   +1 more source