Results 101 to 110 of about 7,287 (179)

Hsp27 regulates epithelial mesenchymal transition, metastasis and proliferation in colorectal carcinoma.

Oncology Letters, 2018
The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated.
Lu Han, Yong Jiang, Dong-Hyeok Han, Weilin Tan   +3 more
semanticscholar   +1 more source

Extracellular Release and Signaling by Heat Shock Protein 27: Role in Modifying Vascular Inflammation

Frontiers in Immunology, 2016
Heat shock protein 27 (HSP27) is traditionally viewed as an intra-cellular chaperone protein with anti-apoptotic properties. However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extra-cellular space ...
Zarah Batulan, Vivek Krishna Pulakazhi Venu, Yumei Li, Yumei Li, Geremy Koumbadinga, Daiana Gisela Alvarez-Olmedo, Chunhua Shi, Edward R. O'Brien   +7 more
doaj   +1 more source

Therapeutic potential of Hsp27 in neurological diseases

Egyptian Journal of Medical Human Genetics, 2019
Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily.
Anila Venugopal, Kasthuri Sundaramoorthy, Balachandar Vellingiri   +2 more
doaj   +1 more source

Heat‐shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF

Molecular Oncology, 2017
The small heat‐shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy.
J. Konda, M. Olivero, D. Musiani, S. Lamba, M. F. Di Renzo   +4 more
semanticscholar   +1 more source

Sensitization of lung cancer cells by altered dimerization of HSP27

OncoTarget, 2017
Heat shock protein 27 (HSP27, HSPB1) induces resistance to anticancer drugs in various cancer types, including non-small cell lung cancer (NSCLC). Therefore, pharmacological inhibition of HSP27 in NSCLC may be a good strategy for anticancer therapy ...
Byeol Choi, Seul-Ki Choi, You Na Park, S. Kwak, H. Lee, Y. Kwon, Y. Na, Yun‐Sil Lee   +7 more
semanticscholar   +1 more source

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

PLoS ONE, 2011
Despite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that flavaglines, a family of natural compounds that display potent neuroprotective effects, may also alleviate ...
Bernard, Yohann, Ribeiro, Nigel, Thuaud, Frédéric, Türkeri, Gülen, Dirr, Ronan, Boulberdaa, Mounia, Nebigil, Canan G, Désaubry, Laurent   +7 more
openaire   +5 more sources

Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection

Emerging Microbes and Infections
A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus replication after entry.
Mandi Wu, Qianya Wan, Xuelian Dan, Yiran Wang, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming-Liang He   +8 more
doaj   +1 more source

Ginkgo biloba extract decreases non-small cell lung cancer cell migration by downregulating metastasis-associated factor heat-shock protein 27.

PLoS ONE, 2014
Heat-shock proteins (HSPs) are molecular chaperones that protect proteins from damage. HSP27 expression is associated with cancer transformation and invasion.
Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Ming-Chan Yang, Yu-Jen Cheng, Jhi-Jhu Hwang, Wei-Hsian Yin, Inn-Wen Chong   +8 more
doaj   +1 more source

Peripheral blood heat shock protein 27 correlates with information processing speed and executive function, potentially serving as a marker for mild cognitive impairment in patients with type 2 diabetes mellitus

Diabetology & Metabolic Syndrome
Background and aims Previous study found that interleukin 1β (IL-1β) is associated with diabetic cognitive dysfunction. Heat shock protein 27 (HSP27) is one of the factors related to IL-1β associated inflammation.
Shufang Yang, Haoqiang Zhang, Wenwen Zhu, Tong Niu, Huzaifa Fareeduddin Mohammed Farooqui, Jue Wang, Mingyue Yang, Enlin Liu, Shaohua Wang   +8 more
doaj   +1 more source

A Diminish the chances of Mediterranean fruit fly Ceratitis capitata eggs surviving by suppressing the expression of the heat shock protein 27 gene (Hsp27).

Tikrit Journal for Agricultural Sciences
The hypothesized role of stress-inducible heat shock proteins is to act as a buffer against environmental variations and affect fitness in suboptimal conditions.
Farhan Al-Behadili, Qasim Ahmed, Thamer Al-Shuwaili, Beibei Li, Yonglin Ren   +4 more
doaj   +1 more source