Results 121 to 130 of about 29,265 (267)

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

PLoS ONE, 2011
Despite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that flavaglines, a family of natural compounds that display potent neuroprotective effects, may also alleviate ...
Bernard, Yohann, Ribeiro, Nigel, Thuaud, Frédéric, Türkeri, Gülen, Dirr, Ronan, Boulberdaa, Mounia, Nebigil, Canan G, Désaubry, Laurent   +7 more
openaire   +5 more sources

Phosphorylation of Ser of Hsp27 correlated with HER-2/ status and lymph node positivity in breast cancer [PDF]

, 2007
BACKGROUND: Abnormal amplification/expression of HER-2/neu oncogene has been causally linked with tumorigenesis and metastasis in breast cancer and associated with shortened overall survival of patients.
Koay, ESC, Wong, LL, Zhang, D
core   +1 more source

AKT-dependent HspB1 (Hsp27) Activity in Epidermal Differentiation [PDF]

, 2007
Ryan F.L. O’Shaughnessy, Jonathan Welti, James C. Cooke, Ariel A. Avilion, Bobby R. Monks, Morris J. Birnbaum, Carolyn Byrne   +6 more
openalex   +1 more source

Therapeutic potential of Hsp27 in neurological diseases

Egyptian Journal of Medical Human Genetics, 2019
Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily.
Anila Venugopal, Kasthuri Sundaramoorthy, Balachandar Vellingiri   +2 more
doaj   +1 more source

Coarse-Graining and Self-Dissimilarity of Complex Networks

, 2004
Can complex engineered and biological networks be coarse-grained into smaller and more understandable versions in which each node represents an entire pattern in the original network? To address this, we define coarse-graining units (CGU) as connectivity
C. Y. Huang, D. H. Wolpert, F. Brglez, H. C. White, H. H. McAdams, H. Ichijo, H. T. Nagle, H. Zhou, J. Berg, J. M. Kyriakis, M. C. Hansen, M. Newman, M. Ronen, Michael Itzkovitz, Nadav Kashtan, P. Horowitz, R. Dobrin, R. Milo, Reuven Levitt, Ron Milo, S. Kirkpatrick, S. Kundu, S. Wasserman, Shalev Itzkovitz, T. C. Bell, Uri Alon, W. Wang   +26 more
core   +1 more source

Targeting Hsp27/eIF4E interaction with phenazine compound: A promising alternative for castration-resistant prostate cancer treatment [PDF]

, 2017
The actual strategy to improve current therapies in advanced prostate cancer involves targeting genes activated by androgen withdrawal, either to delay or prevent the emergence of the castration-refractory phenotype.
Claudia, Andrieu, David, Taieb, Erik, Laurini, Hajer, Ziouziou, Maria, Katsogiannou, Maurizio, Fermeglia, Michel, Camplo, Olivier, Siri, Palma, Rocchi, Ridha, Oueslati, Sabrina, Pricl, Sara, Karaki   +11 more
core   +1 more source

Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection

Emerging Microbes and Infections
A positive-sense (+) single-stranded RNA (ssRNA) virus (e.g. enterovirus A71, EV-A71) depends on viral polypeptide translation for initiation of virus replication after entry.
Mandi Wu, Qianya Wan, Xuelian Dan, Yiran Wang, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming-Liang He   +8 more
doaj   +1 more source

Ginkgo biloba extract decreases non-small cell lung cancer cell migration by downregulating metastasis-associated factor heat-shock protein 27.

PLoS ONE, 2014
Heat-shock proteins (HSPs) are molecular chaperones that protect proteins from damage. HSP27 expression is associated with cancer transformation and invasion.
Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Ming-Chan Yang, Yu-Jen Cheng, Jhi-Jhu Hwang, Wei-Hsian Yin, Inn-Wen Chong   +8 more
doaj   +1 more source

Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis [PDF]

, 2023
Young Jo Yoo, Seulgi Jeon, Hee Kyung Jin, Hee Yeon Won, Mi Gyeong Jeong, Yeseul Cho, Eun Sook Hwang, Younghwa Na, Jaeho Cho, Yun‐Sil Lee   +9 more
openalex   +1 more source

HSP 27 aspossible prognostic factor in patients with oral squamous cell carcinoma. [PDF]

, 2004
Summary. HSP27 belongs to the Heat shock protein (HSP) family, which plays essential functions in cells under physiological conditions and prevents stressinduced cellular damage.
DE ROSA, GAETANO, Giannetti L, Leonardi R, Lo Muzio L, Mariggiò MA, MIGNOGNA, MICHELE DAVIDE, Pannone G, Rubini C, Serpico R, STAIBANO, STEFANIA, Testa NF, Vinella A   +11 more
core