Results 11 to 20 of about 18,813 (211)
Biochemistry Research International, 2011 Hsp27 oligomer is reported to interact with F-actin as a barbed-end-capping protein. The present study determined the binding strength and stoichiometry of the interaction using fluorescence of probes attached to Hsp27 cysteine-137.
Philip Graceffa
doaj +5 more sources
Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules
Oncotarget, 2016 Heat shock protein 27 (HSP27, HSPB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer. The biochemical properties of HSP27 rely on a structural oligomeric and dynamic organization that is important for its chaperone activity.
Kim, Jee Hye +8 more
core +6 more sources
The Role of Hsp27 in Chemotherapy Resistance
Biomedicines, 2022 Heat shock protein (Hsp)-27 is a small-sized, ATP-independent, chaperone molecule that is overexpressed under conditions of cellular stress such as oxidative stress and heat shock, and protects proteins from unfolding, thus facilitating proteostasis and cellular survival.
Marios Lampros +3 more
openaire +4 more sources
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis [PDF]
Journal of Biomedical Science, 2023 Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We have developed a
Seulgi Jeon +8 more
doaj +4 more sources
Frontiers in Microbiology, 2021 Heat shock proteins (HSPs) are a protein family that respond to physiological stress, such as heat, starvation, and infection. As cellular protein chaperones, they play an important role in protein folding, assembly, and degradation.
Xiangrong Li +8 more
doaj +2 more sources
A Role for HSP27 in Sensory Neuron Survival [PDF]
The Journal of Neuroscience, 1999 Peripheral nerve injury in neonatal rats results in the death of the majority of the axotomized sensory neurons by 7 d after injury. In adult animals, however, all sensory neurons survive for at least 4 months after axotomy. How sensory neurons acquire the capacity to survive axonal injury is not known.
S E, Lewis +8 more
openaire +3 more sources
Pharmaceutics, 2021 Relationships between heat shock protein 27 (HSP27) and cancer aggressiveness, metastasis, drug resistance, and poor patient outcomes in various cancer types including non-small cell lung cancer (NSCLC) were reported, and inhibition of HSP27 expression ...
Hawon Yoo +10 more
doaj +2 more sources
Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients. [PDF]
PLoS ONE, 2015 We investigated the relationship between HSP27 phosphorylation and collagen-stimulated activation of platelets in patients with diabetes mellitus (DM). Platelet-rich plasma was prepared from blood of type 2 DM patients.
Haruhiko Tokuda +17 more
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Profile of Serum Heat Shock Protein-27 Level in Patients with Salivary Gland Tumor [PDF]
Journal of Dentistry, 2022 Statement of the Problem: Heat shock protein 27 (HSP27) plays important roles in many cellular processes and has been implicated in different types of diseases such as cancers.Purpose: This study aimed to evaluate the serum level of HSP27 in patients ...
Negar Moghadasi +6 more
doaj +1 more source
HEAT SHOCK PROTEIN 27 IN LARYNGEAL SQUAMOUS CELL CANCER TREATMENT
Сучасні медичні технології, 2020 Heat shock protein 27 (HSP27) belongs to a family of ATP-independent chaperones and plays a fundamental role in cell physiology in various disease states, including cancer. So, it was found that serum HSP27 levels were significantly increased in patients
O. V. Horolec +2 more
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