Results 41 to 50 of about 77,748 (167)
Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice [PDF]
Cell Stress and Chaperones, 2014 The aim of this study was to investigate the potential protective effect of the Hsp70 protein in the cardiac dysfunction induced by doxorubicin (DOX) and the mechanisms of its action. For this purpose, we used both wild-type mice (F1/F1) and Hsp70-transgenic mice (Tg/Tg) overexpressing human HSP70.
Katerina, Naka K +5 more
openaire +2 more sources
All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity [PDF]
Cell Stress & Chaperones, 2007 Divergent relatives of the Hsp70 protein chaperone such as the Hsp110 and Grp170 families have been recognized for some time, yet their biochemical roles remained elusive. Recent work has revealed that these "atypical" Hsp70s exist in stable complexes with classic Hsp70s where they exert a powerful nucleotide-exchange activity that synergizes with ...
Shaner, Lance, Morano, Kevin A
openaire +2 more sources
The hsp70 new functions as a regulator of reproduction both female and male in Ophraella communa
Frontiers in Molecular Biosciences, 2022 Heat shock proteins (Hsps) function as molecular chaperones that enable organisms to withstand stress and maintain normal life activities. In this study, we identified heat shock protein 70 (encoded by hsp70), which exhibits a higher expression in the ...
Yan Zhang +12 more
doaj +1 more source
Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes [PDF]
Cell Stress and Chaperones, 2016 The cellular response to stress is orchestrated by the expression of a family of proteins termed heat shock proteins (hsp) that are involved in the stabilization of basic cellular processes to preserve cell viability and homeostasis. The bulk of hsp function occurs within the cytosol and subcellular compartments.
Victor, Lopez +3 more
openaire +2 more sources
CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis [PDF]
Scientific Reports, 2017 AbstractCLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but the basic molecular mechanisms underlying this function have not yet been clearly elucidated. In this study, using various proteomic tools, we isolated a 70-kDa protein that interacts with
Jang, Jihye +6 more
openaire +4 more sources
Ornamental Plant ResearchChrysanthemum naktongense (C. naktongense) is widely distributed in northern China, and has high biomass and strong resistance. Lanthanum is a nonessential heavy metal element in plants, and it affects C.
Yaohui Gao +5 more
doaj +1 more source
Cedamaz, 2021 En Ecuador se encuentran informadas algunas de las especies de Leishmania pertenecientes al subgénero Viannia (V), causante de enfermedades como leishmaniasis cutánea, cutánea difusa no curativa y mucocutánea. El objetivo de este trabajo fue diagnosticar
Luis Alberto Morocho-Yaguana +3 more
doaj
The remarkable multivalency of the Hsp70 chaperones [PDF]
Cell Stress and Chaperones, 2017 Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this task, they employ a large number of cochaperones and adapter proteins. Here, we review what is known about the interaction between the chaperones and partners, with a strong slant toward structural biology.
Zuiderweg, Erik RP +2 more
openaire +4 more sources
Benzo[a]pyrene-induced changes in carboxylesterase, acetylcholinesterase and heat shock protein 70 of Lymantria dispar (Lepidoptera: Lymantriidae) from unpolluted and polluted forests [PDF]
Archives of Biological Sciences, 2019 Plant vegetation accumulates polycyclic aromatic hydrocarbons (PAHs) among which benzo[a]pyrene (B[a]P) is recognized as being very toxic, including cancerogenic. Lymantria dispar L. larvae are sensitive to changes in the environment, providing potential
Grčić Anja +6 more
doaj +1 more source
Hsp70 in cancer: back to the future [PDF]
Oncogene, 2014 Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling.
Sherman, Michael Y., Gabai, Vladimir L.
openaire +2 more sources