Results 61 to 70 of about 74,429 (262)

All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity [PDF]

Cell Stress & Chaperones, 2007
Divergent relatives of the Hsp70 protein chaperone such as the Hsp110 and Grp170 families have been recognized for some time, yet their biochemical roles remained elusive. Recent work has revealed that these "atypical" Hsp70s exist in stable complexes with classic Hsp70s where they exert a powerful nucleotide-exchange activity that synergizes with ...
Shaner, Lance, Morano, Kevin A
openaire   +2 more sources

Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy

Advanced Functional Materials, EarlyView.
In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova, Ivan V. Zelepukin, Konstantin G. Shevchenko, Gleb V. Tikhonowski, Lyubov V. Gorelik, Anton A. Popov, Anna S. Sogomonyan, Alina Yu. Kapitannikova, Ivan S. Kazantsev, Dmitry V. Dyubo, Daria A. Panova, Daniil I. Tselikov, Anton A. Minnekhanov, Aziz B. Mirkasymov, Georgy A. Ermolaev, Alexander V. Syuy, Gleb I. Tselikov, Aleksey V. Arsenin, Andrei V. Kabashin, Kostya S. Novoselov, Sergey M. Deyev, Valentyn S. Volkov   +21 more
wiley   +1 more source

STUDIES ON BIOCHEMICAL RESPONSES OF TABLE SIZED LABEO ROHITA (HAMILTON, 1822) TO THE THERMAL EXPOSURE AT CRITICAL MAXIMUM TEMPERATURE (CTMAX) [PDF]

Exploratory Animal and Medical Research, 2019
Water temperature of aquatic bodies is gradually getting warmer and may pose threat for survival, health and production of fish in future. The critical temperature maximum (CTmax) is the tool to estimate the upper limit of thermal tolerance of fish but
Prasun Roychowdhury, Mohammad Aftabuddin, Manoj Kumar Pati   +2 more
doaj  

Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae [PDF]

, 2011
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100002&lng=es&nrm=isoCopper is an essential ion that forms part of the active sites of many proteins.
Allende, Miguel, Gallardo, Viviana, Hernandez, Pedro, Mackenzie, Natalia, Reyes, Ariel, Undurraga, Cristian   +5 more
core   +3 more sources

Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes [PDF]

Cell Stress and Chaperones, 2016
The cellular response to stress is orchestrated by the expression of a family of proteins termed heat shock proteins (hsp) that are involved in the stabilization of basic cellular processes to preserve cell viability and homeostasis. The bulk of hsp function occurs within the cytosol and subcellular compartments.
Victor, Lopez, David M, Cauvi, Nelson, Arispe, Antonio, De Maio   +3 more
openaire   +2 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis [PDF]

Scientific Reports, 2017
AbstractCLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but the basic molecular mechanisms underlying this function have not yet been clearly elucidated. In this study, using various proteomic tools, we isolated a 70-kDa protein that interacts with
Jang, Jihye, Kim, Mi Ra, Kim, Taek-Keun, Lee, Woo Ran, Kim, Jong Heon, Heo, Kyun, Lee, Sukmook   +6 more
openaire   +4 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

The remarkable multivalency of the Hsp70 chaperones [PDF]

Cell Stress and Chaperones, 2017
Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this task, they employ a large number of cochaperones and adapter proteins. Here, we review what is known about the interaction between the chaperones and partners, with a strong slant toward structural biology.
Zuiderweg, Erik RP, Hightower, Lawrence E, Gestwicki, Jason E   +2 more
openaire   +4 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source