Results 71 to 80 of about 105,054 (297)

Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice [PDF]

Cell Stress and Chaperones, 2014
The aim of this study was to investigate the potential protective effect of the Hsp70 protein in the cardiac dysfunction induced by doxorubicin (DOX) and the mechanisms of its action. For this purpose, we used both wild-type mice (F1/F1) and Hsp70-transgenic mice (Tg/Tg) overexpressing human HSP70.
Katerina, Naka K, Patra, Vezyraki, Alexandros, Kalaitzakis, Stelios, Zerikiotis, Lampros, Michalis, Charalampos, Angelidis   +5 more
openaire   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Pharmacology of Hsp70 Activation [PDF]

The heat shock protein 90 and 70 (Hsp90 and Hsp70) chaperone system maintains protein quality control for over one hundred client proteins, including many implicated in neurodegenerative disorders, by surveilling substrate binding clefts and selectively ...
Davis, Amanda
core   +6 more sources

All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity [PDF]

Cell Stress & Chaperones, 2007
Divergent relatives of the Hsp70 protein chaperone such as the Hsp110 and Grp170 families have been recognized for some time, yet their biochemical roles remained elusive. Recent work has revealed that these "atypical" Hsp70s exist in stable complexes with classic Hsp70s where they exert a powerful nucleotide-exchange activity that synergizes with ...
Shaner, Lance, Morano, Kevin A
openaire   +2 more sources

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

The hsp70 new functions as a regulator of reproduction both female and male in Ophraella communa

Frontiers in Molecular Biosciences, 2022
Heat shock proteins (Hsps) function as molecular chaperones that enable organisms to withstand stress and maintain normal life activities. In this study, we identified heat shock protein 70 (encoded by hsp70), which exhibits a higher expression in the ...
Yan Zhang, Weihua Ma, Chao Ma, Qinglu Zhang, Zhenya Tian, Zhenya Tian, Zhenqi Tian, Hongsong Chen, Hongsong Chen, Jianying Guo, Fanghao Wan, Zhongshi Zhou, Zhongshi Zhou   +12 more
doaj   +1 more source

Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes [PDF]

Cell Stress and Chaperones, 2016
The cellular response to stress is orchestrated by the expression of a family of proteins termed heat shock proteins (hsp) that are involved in the stabilization of basic cellular processes to preserve cell viability and homeostasis. The bulk of hsp function occurs within the cytosol and subcellular compartments.
Victor, Lopez, David M, Cauvi, Nelson, Arispe, Antonio, De Maio   +3 more
openaire   +2 more sources

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Bacterial Infection Elicits Heat Shock Protein 72 Release from Pleural Mesothelial Cells [PDF]

, 2013
Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro
Porcel, JM, Bielsa, S, Brown, JS, della Vergiliana, JFV, Temple, SEL, Waterer, GW, Lee, YCG, Lansley, SM, Creaney, J   +8 more
core  

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source