The HSP70 family and cancer [PDF]
Carcinogenesis, 2013 The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state.
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HSP70-HSP90 chaperone networking in protein-misfolding disease
, 2022 Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality control and function.
Xavier Aran Guiu (5369765) +5 more
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Changes of cellular stress response related hsp70 and abcb1 transcript and Hsp70 protein levels in Siberian freshwater amphipods upon exposure to cadmium chloride in the lethal concentration range [PDF]
PeerJ, 2020 The induction of cellular stress response systems, heat shock protein hsp70/Hsp70 and multixenobiotic transporter abcb1, by cadmium chloride (CdCl2) was explored in amphipod species with different stress adaptation strategies from the Lake Baikal area ...
Marina V. Protopopova +2 more
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Frontiers in Bioscience-Landmark, 2023 Background: The mortality rate of colorectal cancer (CRC) ranks second worldwide. Previous research had indicated that licochalcone A (LA) was a flavonoid in licorice with diverse anticancer effects.
Tianpeng Li +11 more
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The relationship between HSP70 and level of leptin and luteinizing hormones in female rats exposed to chronic and acute heat stress [PDF]
Iraqi Journal of Veterinary Sciences, 2020 The current search experiments designed to study the effect of chronic and acute heat stress on the relationship between HSP70, leptin and luteinizing hormones level in female rats.
Hiyam N. Matty, Ashwaq A. Hassan
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The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells
Vaccine Research, 2020 Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani +3 more
doaj
HSP70 promotes MLKL polymerization and necroptosis
Molecular & Cellular Oncology, 2020 Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Andrea N. Johnston, Zhigao Wang
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Comparison of heat-shock responses between the hydrothermal vent shrimp Rimicaris exoculata and the related coastal shrimp Palaemonetes varians [PDF]
, 2010 The deep-sea vent shrimp Rimicaris exoculata is believed to occur at the hot end of the hydrothermal biotope in order to provide essential elements to its epibiosis. Because it is found close to hot venting water, R.
Thomas Chertemps +11 more
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The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions? [PDF]
Cell Stress and Chaperones, 2009 Although heat shock (stress) proteins are typically regarded as being exclusively intracellular molecules, it is now apparent that they can be released from cells in the absence of cellular necrosis. We and others have reported the presence of Hsp60 (HSPD1) and Hsp70 (HSPA1A) in the circulation of normal individuals and our finding that increases in ...
A Graham, Pockley +2 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source