Results 1 to 10 of about 58,005 (120)

Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor

Cancer Biology & Therapy, 2022
Mitochondria are key tumor drivers, but their suitability as a therapeutic target is unknown. Here, we report on the preclinical characterization of Gamitrinib (GA mitochondrial matrix inhibitor), a first-in-class anticancer agent that couples the Heat ...
Umar Hayat, Gary T. Elliott, Anthony J. Olszanski, Dario C. Altieri   +3 more
doaj   +1 more source

A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

Disease Models & Mechanisms, 2022
Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo, Anne Brickenden, Hansen Liu, Cynthia Yeung, Wing-Yiu Choy, Martin L. Duennwald   +5 more
doaj   +1 more source

Pioglitazone restores phosphorylation of downregulated caveolin-1 in right ventricle of monocrotaline-induced pulmonary hypertension

Clinical and Experimental Hypertension, 2022
Background Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary arteries; however, less is known regarding its role in the hypertrophied right ventricle
Eva Malikova, Zuzana Kmecova, Gabriel Doka, Lenka Bies Pivackova, Peter Balis, Simona Trubacova, Eva Velasova, Peter Krenek, Jan Klimas   +8 more
doaj   +1 more source

Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways

Cells, 2020
Heat stress (HS) often causes sudden death of humans and animals due to heart failure, mainly resulting from the contraction of cardiac microvasculature followed by myocardial ischemia.
Xiaohui Zhang, Bixia Chen, Jiaxin Wu, Junzhou Sha, Bo Yang, Jie Zhu, Jiarui Sun, Jörg Hartung, Endong Bao   +8 more
doaj   +1 more source

Role of heat shock in building up proteins HSP70 , HSP90, increasing anthocyanins content in callus of strawberry Fragaria ananassa Duch. [PDF]

Mesopotamia Journal of Agriculture
This study was conducted in the genetic applications laboratories of University of Mosul, College of Education for Pure Sciences. Heat shock proteins HSPs were constructed for increase of withstand long-term physical shocks, and production of resistant ...
Waad Al-Hamdani
doaj   +1 more source

Universal primers for amplifying the complete coding sequence of cytoplasmic heat shock protein 90 (HSP90) in Lepidoptera

European Journal of Entomology, 2011
Using sequence alignment, a conserved domain in the 3' untranslated region (UTR) of the cytoplasmic heat shock protein 90 (HSP90) of Lepidoptera was found. This region is highly variable in other insect groups.
Peng Jun XU, Tong LI, Jin Hua XIAO, Robert W. MURPHY, Huang DA WEI   +4 more
doaj   +1 more source

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics [PDF]

Open Biology, 2012
Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression.
Peter W. Piper, Stefan H. Millson
doaj   +1 more source

Effects of ultraviolet-C and microwave irradiation on the expression of heat shock protein genes in the maize weevil (Coleoptera: Curculionidae)

European Journal of Entomology, 2016
The maize weevil, Sitophilus zeamais (Motschulsky), is a major pest of stored grain kernels. Irradiation is an established technique for controlling insects in stored grain and is a major stress factor affecting these insects.
Jatuporn TUNGJITWITAYAKUL, Nujira TATUN, Boongeua VAJARASATHIRA, Sho SAKURAI   +3 more
doaj   +1 more source

MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis

Cancer Biology & Medicine, 2022
Objective: In various cancers, migration and invasion inhibitory protein (MIIP) is expressed at low level and is involved in cancer pathogenesis. Herein, we sought to explore the function of MIIP in clear cell renal cell carcinoma (ccRCC). Methods: CCK-8,
Fengqi Yan, Qinhao Wang, Mingyuan Xia, Yi Ru, Wei Hu, Guang Yan, Xin Xiong, Mei Zhang, Jiancai Wang, Qi Li, Bo Zhang, He Wang, Wei Lin, Guojun Wu, Xia Li   +14 more
doaj   +1 more source

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer

Pharmaceuticals, 2012
Hsp90 is an abundant protein in mammalian cells. It forms several discrete complexes, each containing distinct groups of co-chaperones that assist protein folding and refolding during stress, protein transport and degradation. It interacts with a variety
Christos A. Papadimitriou, Konstantinos Koutsoukos, Evangelos Bournakis, Flora Zagouri   +3 more
doaj   +1 more source