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Functional interplay between heat shock protein 90 (HSP90) and heat shock factors (HSFs) [PDF]

Cell Stress & Chaperones
Maintenance of protein homeostasis, also known as proteostasis, is essential for cellular survival under both basal and stress conditions. Proteostasis relies on a coordinated action between molecular chaperones, such as heat shock proteins (HSPs), and ...
Abir Chakraborty, Lea Sistonen, Pia Roos-Mattjus   +2 more
doaj   +4 more sources

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection [PDF]

International Journal of Molecular Sciences, 2021
Heat shock proteins (HSPs) are a large group of chaperones found in most eukaryotes and bacteria. They are responsible for the correct protein folding, protection of the cell against stressors, presenting immune and inflammatory cytokines; furthermore, they are important factors in regulating cell differentiation, survival and death.
Anna Lubkowska, Waldemar Pluta, Aleksandra Strońska-Pluta   +2 more
exaly   +3 more sources

The evolution of heat shock protein 90 C-terminal inhibitors: From novobiocin to potential clinical candidates [PDF]

Cell Stress & Chaperones
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that regulates the maturation of various client proteins. Most therapeutic studies have focused on N-terminal Hsp90 inhibitors, but these are limited by dose-escalating toxicities ...
Xiaosheng Jiang, Brian S.J. Blagg
doaj   +2 more sources

Coordinated regulation of the metaboproteome by Hsp90 chaperones controls metabolic plasticity [PDF]

iScience
Summary: Heat shock protein 90 (Hsp90) chaperones participate in the stabilization and activation of hundreds of proteins, thereby acting as signaling hubs.
R. Felipe Perez, Gianna L. Mochi, Julia K. Burkacki, Victoria Zoccoli-Rodriguez, Landon D. Arcadi, Sarah J. Backe, Joel R. Wilmore, Mark R. Woodford   +7 more
doaj   +2 more sources

The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells. [PDF]

PLoS ONE, 2013
The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes.
Zohar Bromberg, Pierre Goloubinoff, Younousse Saidi, Yoram George Weiss   +3 more
doaj   +1 more source

Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

Pharmaceutics, 2021
Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents.
Jaka Dernovšek, Živa Zajec, Martina Durcik, Lucija Peterlin Mašič, Martina Gobec, Nace Zidar, Tihomir Tomašič   +6 more
doaj   +1 more source

The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90

Advanced Science, 2023
AbstractProtein dynamics have been investigated on a wide range of time scales. Nano‐ and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes. However, it is largely unknown how fast (local) fluctuations can lead to slow global (allosteric) changes.
Sohmen, Benedikt, Beck, Christian, Frank, Veronika, Seydel, Tilo, Hoffmann, Ingo, Hermann, Bianca, Nüesch, Mark, Grimaldo, Marco, Schreiber, Frank, Wolf, Steffen, Roosen‐runge, Felix, Hugel, Thorsten   +11 more
openaire   +7 more sources

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani

mSystems, 2018
The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins.
Eugenia Bifeld, Stephan Lorenzen, Katharina Bartsch, Juan-José Vasquez, T. Nicolai Siegel, Joachim Clos   +5 more
doaj   +3 more sources

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis [PDF]

Cell Stress and Chaperones, 2021
Atopic dermatitis (AD) is one of the most common chronic inflammatory dermatoses characterized by persistent itching and recurrent eczematous lesions. While the primary events and key drivers of AD are topics of ongoing debate, cutaneous inflammation due to inappropriate IgE (auto)antibody-related immune reactions is frequently considered.
Krzysztof Sitko, Marta Bednarek, Jagoda Mantej, Magdalena Trzeciak, Stefan Tukaj   +4 more
openaire   +2 more sources

Heat Shock Proteins and Ferroptosis

Frontiers in Cell and Developmental Biology, 2022
Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize
Ying Liu, Ying Liu, Ying Liu, Ying Liu, Lin Zhou, Lin Zhou, Lin Zhou, Lin Zhou, Yunfei Xu, Yunfei Xu, Yunfei Xu, Yunfei Xu, Kexin Li, Kexin Li, Kexin Li, Kexin Li, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Qing Xu, Qing Xu, Qing Xu, Qing Xu, Jie Zhao   +28 more
doaj   +1 more source