Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation [PDF]
BiomedicinesBackground/Objectives: Psoriasis is a chronic, systemic, and multifactorial disease affecting approximately 1–2% of the Caucasian population. It is characterized by distinct histopathological features, including epidermal hyperplasia and infiltration of ...
Aikaterini Kalantidou +8 more
doaj +2 more sources
SARS-CoV-2 Helicase (NSP13) Interacts with Mammalian Polyamine and HSP Partners in Promoting Viral Replication [PDF]
Current Issues in Molecular BiologyWe present a computational study that precedes the potential interactions between SARS-CoV-2 helicase (NSP13) and selected host proteins implicated in chaperone-assisted folding and polyamine metabolism.
Zingisa Sitobo +7 more
doaj +2 more sources
Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms [PDF]
VirulenceAs opportunistic intracellular pathogens, viruses rely on numerous sequential interactions between host and viral factors for their replication. Given the significance of molecular chaperones (heat shock protein 70 and heat shock protein 90) in mediating
Chen Li +5 more
doaj +2 more sources
Genome-wide transcriptomic analysis reveals autophagy and HSP70-mediated mechanisms underlying thermal stress adaptation in Mytilus coruscus [PDF]
BMC GenomicsRising ocean temperatures driven by global warming pose a major threat to marine organisms. In this study, we examined physiological and molecular changes in the muscle, gill, foot, and mantle tissues of Mytilus coruscus under thermal stress ...
Chao Li +4 more
doaj +2 more sources
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
Life Science Alliance, 2022 Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
Shingo Kose +5 more
doaj +1 more source
Non-lethal heat shock increased Hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp. [PDF]
PLoS ONE, 2013 Non-lethal heat shock boosts bacterial and viral disease tolerance in shrimp, possibly due to increases in endogenous heat shock protein 70 (Hsp70) and/or immune proteins.
Nguyen Hong Loc +5 more
doaj +1 more source
Transfection of Heat Shock Protein 70kDa (HSP70)
International Journal of Peptide Research and Therapeutics, 2022 Abstract Heat shock protein 70kDa (HSP70) is a major protein family in the cell protections against stress-induced denaturation and aggregation and in the folding of nascent proteins. It is a highly conserved protein that can be found in most organisms and is strongly connected to several intracellular pathways such as protein folding and ...
Maxime Gestin +5 more
openaire +1 more source
STRUCTURAL AND BIOCHEMICAL ELUCIDATION OF MOSQUITO HEAT SHOCK PROTEIN 70
International Journal of Infectious Diseases, 2023 Intro: Heat Shock Proteins function as molecular chaperones and found present in almost all living organism. Furthermore, HSPs are divided into many different classes based on their molecular mass, amino acid composition, and physiological function ...
S. Chakraborti
doaj +1 more source
The membrane-associated transient receptor potential vanilloid channel is the central heat shock receptor controlling the cellular heat shock response in epithelial cells. [PDF]
PLoS ONE, 2013 The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes.
Zohar Bromberg +3 more
doaj +1 more source
Cells, 2022 Heat shock proteins protect plants from abiotic stress, such as salt, drought, heat, and cold stress. HSP70 is one of the major members of the heat shock protein family.
Javaria Tabusam +6 more
doaj +1 more source