Results 21 to 30 of about 55,389 (309)

The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis

Pathophysiology, 2023
Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs).
Iman Aolymat, Ma’mon M. Hatmal, Amin N. Olaimat   +2 more
doaj   +1 more source

HEAT SHOCK PROTEIN HSP70: PREREQUISITES FOR USE AS A MEDICINAL PRODUCT

Pharmacy & Pharmacology, 2021
Heat shock protein Hsp70 is one of the main cytoprotection components under the action of various external stimuli. The analysis of the literature data shows that nowadays, the researches’ overwhelming evidence has proven the role of Hsp70 as a biological target for the drug development; however, the ideas about its use as a drug are often ...
V. M. Pokrovsky, E. A. Patrakhanov, O. V. Antsiferov, I. M. Kolesnik, A. V. Belashova, V. A. Soldatova, O. N. Pokopeiko, A. Yu. Karagodina, I. A. Arkhipov, D. G. Voronina, D. N. Sushkova   +10 more
openaire   +3 more sources

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
W Neupert, Herrmann, Johannes M., Stuart, Rosemary A., Neupert, Walter, J M Herrmann, Craig, Elisabeth A., E A Craig, R A Stuart   +7 more
core   +1 more source

Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids

European Journal of Medical Research, 2009
Objective Heat shock proteins assist cellular protein folding and are required for the normal activity of steroid receptors. In this study we assessed nuclear HSP90 and HSP70 proteins and mRNA levels in cells isolated from induced sputum of chronic ...
Holownia A, Mroz RM, Kielek A, Chyczewska E, Braszko JJ   +4 more
doaj   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Manzenrieder, Florian, Elfriede Noessner, Noessner, Elfriede, Bendz, H., Buchner, J., Bendz, Henriette, Johannes Buchner, Nößner, E., Issels, Rolf D., Florian Manzenrieder, Kessler, H., Rolf D. Issels, Pandya, M.J., Manzenrieder, F., Issels, R.D., Kessler, Horst, Pandya, Maya J., Henriette Bendz, Maya J. Pandya, Buchner, Johannes, Horst Kessler   +20 more
core   +1 more source

The molluscan HSP70s and their expression in hemocytes [PDF]

Invertebrate Survival Journal, 2013
The heat shock protein 70s (HSP70s) are a class of functionally related proteins involved in the folding and unfolding, translocation of other proteins, and stress responses in almost all organisms.
L Wang, C Yang, L Song
doaj   +1 more source

Membrane Fluidization Governs the Coordinated Heat-Inducible Expression of Nucleus- and Plastid Genome-Encoded Heat Shock Protein 70 Genes in the Marine Red Alga Neopyropia yezoensis

Plants, 2023
Heat shock protein 70 (HSP70) is an evolutionarily conserved protein chaperone in prokaryotic and eukaryotic organisms. This family is involved in the maintenance of physiological homeostasis by ensuring the proper folding and refolding of proteins.
Koji Mikami, Ho Viet Khoa
doaj   +1 more source

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target [PDF]

Journal of Medicinal Chemistry, 2010
Heat shock protein 70 (Hsp70) is a molecular chaperone that is expressed in response to stress. In this role, Hsp70 binds to its protein substrates and stabilize them against denaturation or aggregation until conditions improve.1 In addition to its functions during a stress response, Hsp70 has multiple responsibilities during normal growth; it assists ...
Christopher G, Evans, Lyra, Chang, Jason E, Gestwicki   +2 more
openaire   +2 more sources

Heat Shock Proteins and Ferroptosis

Frontiers in Cell and Developmental Biology, 2022
Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize
Ying Liu, Ying Liu, Ying Liu, Ying Liu, Lin Zhou, Lin Zhou, Lin Zhou, Lin Zhou, Yunfei Xu, Yunfei Xu, Yunfei Xu, Yunfei Xu, Kexin Li, Kexin Li, Kexin Li, Kexin Li, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Qing Xu, Qing Xu, Qing Xu, Qing Xu, Jie Zhao   +28 more
doaj   +1 more source

Heat Shock Proteins (HSP70) as Biomarkers in Ecotoxicological Studies

Ecotoxicology and Environmental Safety, 1997
Hsp70, so-called stress proteins, were studied in the centipede Lithobius mutabilis when exposed in laboratory tests to different concentrations of the insecticide dimethoate (DMT; 0, 0.012, 0.111 mg kg-1 dwt), the detergent linear alkilobenzene sulfonate (LAS; 0, 16, 80, 400, 2000, 10,000 mg kg-1 dwt), and copper (Cu; 0, 56, 167, 500, 1000, 1500 mg kg-
Pyza, Elżbieta, Mak, Paweł, Kramarz, Paulina, Laskowski, Ryszard   +3 more
openaire   +3 more sources