Results 31 to 40 of about 50,507 (259)

Hsp70 dynamics in vivo: effect of heat shock and protein aggregation [PDF]

Journal of Cell Science, 2004
The molecular chaperone Hsp70 interacts with misfolded proteins and also accumulates in the nucleus during heat shock. Using GFP-Hsp70 and fluorescence recovery after photobleaching, we show that Hsp70 accumulates in the nucleus during heat shock not only because its inflow rate increases but also because of a marked decrease in its outflow rate ...
Xian-Chun, Zeng, Samir, Bhasin, Xufeng, Wu, Joeng-Goo, Lee, Shivani, Maffi, Christopher J, Nichols, Kyung Jin, Lee, J Paul, Taylor, Lois E, Greene, Evan, Eisenberg   +9 more
openaire   +2 more sources

Membrane-anchored heat-shock protein 70 (Hsp70) in cancer

Cancer Letters, 2020
Hsp70 is a highly conserved and inducible heat shock protein that belongs to the HSP70 family of molecular chaperones and plays a central role in protein homeostasis. The main function of Hsp70 is to protect cells from physiological, pathological and environmental insults, as it assists an ATP-dependent manner the process of protein folding.
Elmallah, Mohammed I.Y., Cordonnier, Marine, Vautrot, Valentin, Chanteloup, Gaëtan, Garrido, Carmen, Gobbo, Jessica   +5 more
openaire   +6 more sources

The neuroprotective potential of heat shock protein 70 (HSP70)

Molecular Medicine Today, 1999
In response to many metabolic disturbances and injuries, including stroke, neurodegenerative disease, epilepsy and trauma, the cell mounts a stress response with induction of a variety of proteins, most notably the 70-kDa heat shock protein (HSP70). Whether stress proteins are neuroprotective has been hotly debated, as these proteins might be merely an
M A, Yenari, R G, Giffard, R M, Sapolsky, G K, Steinberg   +3 more
openaire   +2 more sources

Dataset of Nematostella vectensis Hsp70 isoform interactomes upon heat shock

Data in Brief, 2019
Nematostella vectensis is an estuarine sea anemone that has emerged as a model species to characterize molecular responses to physiological stressors due to its exposure to diverse, extreme abiotic conditions.
Laura E. Knighton, Nitika, Donald Wolfgeher, Adam M. Reitzel, Andrew W. Truman   +4 more
doaj   +1 more source

Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]

Cancer, 2003
AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry, Lebret, R William G, Watson, Vincent, Molinié, Amanda, O'Neill, Christophe, Gabriel, John M, Fitzpatrick, Henry, Botto   +6 more
openaire   +2 more sources

Mutants of Tobacco mosaic virus with Temperature-Sensitive Coat Proteins Induce Heat Shock Response in Tobacco Leaves

Molecular Plant-Microbe Interactions, 2001
We analyzed, with respect to heat shock proteins (HSPs), systemically reacting tobacco leaves inoculated with Tobacco mosaic virus (TMV), wild-type vulgare, and temperature-sensitive coat protein (CP) mutants Ni 118 (P20L) and flavum (D19A), kept at 23 ...
Harald Jockusch, Christiane Wiegand, Birgit Mersch, Daniela Rajes   +3 more
doaj   +1 more source

Identification of heat shock protein hsp70 homologues in chloroplasts. [PDF]

Proceedings of the National Academy of Sciences, 1990
Cytoplasmic members of the heat shock protein hsp70 family have recently been implicated in the transport of proteins to the endoplasmic reticulum and mitochondria. In addition, other hsp70 homologues have been found in the endoplasmic reticulum and mitochondria and, at least for the endoplasmic reticulum hsp70 homologue, may be involved in the proper ...
J S, Marshall, A E, DeRocher, K, Keegstra, E, Vierling   +3 more
openaire   +2 more sources

Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity. [PDF]

PLoS ONE, 2015
Tumor-derived heat shock protein70-peptide complexes (HSP70.PC-Tu) have shown great promise in tumor immunotherapy due to numerous advantages. However, large-scale phase III clinical trials showed that the limited immunogenicity remained to be enhanced ...
Yunfei Zhang, Yong Zhang, Jun Chen, Yunyan Liu, Wen Luo   +4 more
doaj   +1 more source

Evolution of Thermotolerance and Variation in the Heat Shock Protein, Hsp70 [PDF]

American Zoologist, 1999
Low to moderate levels of stress induce a class of molecular chaperones called heat shock proteins (Hsps), which protect cells, tissues and whole organisms from more severe stress. In higher Eukaryotes, Hsp70 is one of the principle heat-induced chaperones.
ROBERT A. KREBS, BRIAN R. BETTENCOURT
openaire   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source