Heat Shock Protein 90 (HSP90) and Immune Regulation
Journal of Bacteriology and Virology, 2015 Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses.
Bo-Kyung Kim, So-Youn Woo
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Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus. [PDF]
Journal of Clinical Investigation, 1988 Patients with systemic lupus erythematosus (SLE) develop multiple autoantibodies to self-antigens. Analysis of autoantibody systems in this and related autoimmune disorders can provide information of etiologic and pathogenetic significance. We report here a previously unrecognized autoantibody to the 90,000-D heat-shock protein, hsp90, a molecule ...
S, Minota +3 more
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Agricultura, 2012 The combined effect of drought stress and heat shock on the induction of boiling stable proteins viz: WGA, SOD, HSP90,Aquaporin, CyPs, APase and LEA proteins was studied in 3-days old seedlings of drought tolerant and drought susceptible cultivars of ...
Gurmeen Rakhra, Arun Dev Sharma
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Hsp90 pan and Isoform-Selective Inhibitors as Sensitizers for Cancer Immunotherapy
PharmaceuticalsThe 90 kDa heat shock proteins (Hsp90) are molecular chaperones that regulate the stability and maturation of numerous client proteins implicated in the regulation of cancer hallmarks.
Shiying Jia +3 more
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The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. [PDF]
PLoS ONE, 2015 Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease ...
Chao Shi +8 more
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Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds [PDF]
BioDiscovery, 2014 In diseases such as cancer, Alzheimer’s disease or malaria, disease-related proteins take advantage of the heat shock protein (HSP) control system for their own activation or maturation.
Emilia Schax +7 more
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Functions and Therapeutic Use of Heat Shock Proteins in Hepatocellular Carcinoma
LiversHeat shock proteins are intracellular proteins expressed in prokaryotes and eukaryotes that help protect the cell from stress. They play an important role in regulating cell cycle and cell death, work as molecular chaperons during the folding of newly ...
Ramakrushna Paul +6 more
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A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
PLoS ONE, 2012 Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis.
Alexander F Bruns +11 more
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Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Extracellular Hsp90 proteins, including "membrane-bound", "released" and "secreted", were first reported more than two decades ago. Only studies of the past 7years have begun to reveal a picture for when, how and why Hsp90 gets exported by both normal and tumor cells. Normal cells secrete Hsp90 in response to tissue injury.
Li, Wei, Sahu, Divya, Tsen, Fred
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Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
Journal of Hematology & Oncology, 2018 Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li +3 more
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