Results 21 to 30 of about 34,140 (152)

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Pharmaceutics, 2022
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of ...
Mina Ardestani, Zahra Khorsandi, Fariba Keshavarzipour, Siavash Iravani, Hojjat Sadeghi-Aliabadi, Rajender S. Varma   +5 more
doaj   +1 more source

Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance

Cells, 2022
Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturation of newly synthesized poly-peptides and provides a shelter for the turnover of misfolded or denatured proteins. In cancers, the client proteins of HSP90
Jian Zhang, Houde Li, Yu Liu, Kejia Zhao, Shiyou Wei, Eric T. Sugarman, Lunxu Liu, Gao Zhang   +7 more
doaj   +1 more source

Heat stress induces expression of HSP genes in genetically divergent chickens. [PDF]

PLoS ONE, 2017
BACKGROUND:Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain.
Haniel Cedraz, Juliana Gracielle Gonzaga Gromboni, Antonio Amandio Pinto Garcia, Ronaldo Vasconcelos Farias Filho, Teillor Machado Souza, Eduardo Ribeiro de Oliveira, Elizangela Bonfim de Oliveira, Carlos Souza do Nascimento, Camila Meneghetti, Amauri Arias Wenceslau   +9 more
doaj   +1 more source

Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids

European Journal of Medical Research, 2009
Objective Heat shock proteins assist cellular protein folding and are required for the normal activity of steroid receptors. In this study we assessed nuclear HSP90 and HSP70 proteins and mRNA levels in cells isolated from induced sputum of chronic ...
Holownia A, Mroz RM, Kielek A, Chyczewska E, Braszko JJ   +4 more
doaj   +1 more source

Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism

Redox Biology, 2019
Aging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of ...
José Pedro Castro, Raquel Fernando, Sandra Reeg, Walter Meinl, Henrique Almeida, Tilman Grune   +5 more
doaj   +1 more source

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90 [PDF]

Organic & Biomolecular Chemistry, 2014
A series of macrolactam analogues of the naturally occurring resorcylic acid lactone radicicol have been synthesised from methyl orsellinate in 7 steps, involving chlorination, protection of the two phenolic groups, and hydrolysis to the benzoic acid. Formation of the dianion and quenching with a Weinreb amide results in acylation of the toluene methyl
Dutton, Bridie L., Kitson, Russell R.A., Parry-Morris, Sarah, Roe, S. Mark, Prodromou, Chrisostomos, Moody, Christopher J.   +5 more
openaire   +3 more sources

Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma. [PDF]

PLoS ONE, 2014
Heat shock protein 90 (HSP90) inhibitors are potential drugs for cancer therapy. The inhibition of HSP90 on cancer cell growth largely through degrading client proteins, like Akt and p53, therefore, triggering cancer cell apoptosis.
Weiwei Guo, Lichong Yan, Ling Yang, Xiaoyu Liu, Qiukai E, Peiye Gao, Xiaofei Ye, Wen Liu, Ji Zuo   +8 more
doaj   +1 more source

Hsp90: From Cellular to Organismal Proteostasis

Cells, 2022
Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases.
Milán Somogyvári, Saba Khatatneh, Csaba Sőti   +2 more
doaj   +1 more source

Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells

Cells, 2020
Tumor cells exhibit therapeutic stress resistance-associated secretory phenotype involving extracellular vesicles (EVs) such as oncosomes and heat shock proteins (HSPs). Such a secretory phenotype occurs in response to cell stress and cancer therapeutics.
Takanori Eguchi, Chiharu Sogawa, Kisho Ono, Masaki Matsumoto, Manh Tien Tran, Yuka Okusha, Benjamin J. Lang, Kuniaki Okamoto, Stuart K. Calderwood   +8 more
doaj   +1 more source

Interacting Proteins Of Heat Shock Factors (HSF) and Heat Shock Protein 90 (HSP90) in Theobroma cacao L. Through In Silico Study

Jurnal Ilmu Dasar
Cocoa (Theobroma cacao L.) plants are sensitive to drought, so drought stress can reduce cocoa bean production. Heat stress can trigger gene expression as plant defense. Heat Shock Factors (HSF) play key role in responding to plant stress.
Waki'atil Rosida, Qori’atul Mustafidah, Dwi Indahning Rohmah, Edia Fitri Dwinianti   +3 more
doaj   +1 more source