Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus [PDF]
Cancers, 2014 Her2 overexpression and amplification can be found in a significant subset of esophageal adenocarcinomas. The activity of Her2 has been shown to be modulated by molecular chaperones such as HSP90. We analyzed expression/amplification data for HSP90 and Her2 on 127 primary resected esophageal adenocarcinomas in order to evaluate a possible relationship ...
Slotta-Huspenina J +4 more
openaire +3 more sources
Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation [PDF]
, 2008 Introduction The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and functional differentiation of the mammary gland.
Liu, R. +26 more
core +2 more sources
ChemistryOpen, 2019 Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency.
Dr. Peng Liu +12 more
doaj +1 more source
Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]
, 2009 Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Manzenrieder, Florian +20 more
core +1 more source
Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [PDF]
Cancer, 2003 AbstractBACKGROUNDHeat shock proteins (HSPs) are synthesized by cells in response to various stress conditions, including carcinogenesis. The expression of HSPs in neoplasia has been implicated in the regulation of apoptosis, and HSPs also can act by increasing immunity. In the current study, the authors attempted to clarify the significance of HSPs in
Thierry, Lebret +6 more
openaire +2 more sources
Comparison of heat-shock responses between the hydrothermal vent shrimp Rimicaris exoculata and the related coastal shrimp Palaemonetes varians [PDF]
, 2010 The deep-sea vent shrimp Rimicaris exoculata is believed to occur at the hot end of the hydrothermal biotope in order to provide essential elements to its epibiosis. Because it is found close to hot venting water, R.
Thomas Chertemps +11 more
core +1 more source
Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications
Pharmaceutics, 2022 Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of ...
Mina Ardestani +5 more
doaj +1 more source
Innovative approaches to monitor mutant huntingtin and to facilitate its degradation in Huntington's disease models [PDF]
, 2011 Huntington’s disease (HD) is a dominant genetic neurodegenerative disease caused by a mutation in the exon 1 of the huntingtin gene. The clinical symptoms, such as motor disturbances (chorea), cognitive decline and psychiatric impairments are usually ...
Baldo, Barbara
core +1 more source
Heat stress induces expression of HSP genes in genetically divergent chickens. [PDF]
PLoS ONE, 2017 BACKGROUND:Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain.
Haniel Cedraz +9 more
doaj +1 more source
Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance
Cells, 2022 Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturation of newly synthesized poly-peptides and provides a shelter for the turnover of misfolded or denatured proteins. In cancers, the client proteins of HSP90
Jian Zhang +7 more
doaj +1 more source