Results 31 to 40 of about 34,140 (152)

Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1

Cell Reports, 2019
Summary: Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding. Their function in the cytosol has been well studied. Notably, chaperones are also present in the nucleus, a compartment where proteins enter after completing de ...
Aneliya Antonova, Barbara Hummel, Ashkan Khavaran, Desiree M. Redhaber, Fernando Aprile-Garcia, Prashant Rawat, Kathrin Gundel, Megan Schneck, Erik C. Hansen, Jan Mitschke, Gerhard Mittler, Cornelius Miething, Ritwick Sawarkar   +12 more
doaj   +1 more source

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm
Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It collaborates
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
doaj   +1 more source

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

Acta Pharmaceutica Sinica B, 2012
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of ...
Yong Li, Dongmei Zhang, Jun Xu, Junmin Shi, Lei Jiang, Nan Yao, Wencai Ye   +6 more
doaj   +1 more source

In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei

Frontiers in Molecular Biosciences, 2022
African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host.
Miebaka Jamabo, Stephen John Bentley, Paula Macucule-Tinga, Praise Tembo, Adrienne Lesley Edkins, Aileen Boshoff   +5 more
doaj   +1 more source

Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90)

, 2023
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a widely used technique for genome-wide mapping of protein-DNA interactions and epigenetic marks in vivo. Recent studies have suggested an important role of heat shock protein 90 (Hsp90) in chromatin. This molecular chaperone assists other proteins to acquire their mature and functional
openaire   +2 more sources

RET Is a Heat Shock Protein 90 (HSP90) Client Protein and Is Knocked Down upon HSP90 Pharmacological Block [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2010
Mutations of the RET receptor tyrosine kinase are associated to multiple endocrine neoplasia type 2 (MEN2) and sporadic medullary thyroid carcinoma (MTC). The heat shock protein (HSP) 90 chaperone is required for folding and stability of several kinases.
Alfano L., Guida T., Provitera L., VECCHIO, GIANCARLO, Billaud M., SANTORO, MASSIMO, CARLOMAGNO, Francesca   +6 more
openaire   +5 more sources

The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth

Parasite, 2017
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects almost all warm-blooded vertebrates. Heat shock proteins (HSP) regulate key signal transduction events in many organisms, and heat shock protein 90 (Hsp90) plays an ...
Sun Hongchao, Zhuo Xunhui, Zhao Xianfeng, Yang Yi, Chen Xueqiu, Yao Chaoqun, Du Aifang   +6 more
doaj   +1 more source

Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages

Journal of Inflammation, 2005
Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub, Slezak Kinga, Guzik Krzysztof, Kowalczyk Aleksandra, Rokita Hanna   +4 more
doaj   +1 more source

In silico genomic and proteomic analyses of three heat shock proteins (HSP70, HSP90-α, and HSP90-β) in even-toed ungulates

Electronic Journal of Biotechnology, 2021
Background: Heat shock proteins (HSPs) play important roles in the responses to different environmental stresses. In this study, the genomic and proteomic characteristics of three HSPs (HSP70, HSP90-α and HSP90-β) in five even-toed ungulates (sheep ...
Sayed Haidar Abbas Raza, Abdallah A. Hassanin, Aya I.M. Dhshan, Sameh A. Abdelnour, Rajwali Khan, Chugang Mei, Linsen Zan   +6 more
doaj   +1 more source

Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms

Virulence
As opportunistic intracellular pathogens, viruses rely on numerous sequential interactions between host and viral factors for their replication. Given the significance of molecular chaperones (heat shock protein 70 and heat shock protein 90) in mediating
Chen Li, Yingru Ma, Chang Liu, Shaojian Xu, Jianli Shi, Jun Li   +5 more
doaj   +1 more source