Results 11 to 20 of about 34,140 (152)

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer [PDF]

Pharmaceuticals, 2012
Hsp90 is an abundant protein in mammalian cells. It forms several discrete complexes, each containing distinct groups of co-chaperones that assist protein folding and refolding during stress, protein transport and degradation. It interacts with a variety of proteins that play key roles in breast neoplasia including estrogen receptors, tumor suppressor ...
Zagouri, F., Bournakis, E., Koutsoukos, K., Papadimitriou, C.A.   +3 more
openaire   +4 more sources

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis [PDF]

Cell Stress and Chaperones, 2021
Atopic dermatitis (AD) is one of the most common chronic inflammatory dermatoses characterized by persistent itching and recurrent eczematous lesions. While the primary events and key drivers of AD are topics of ongoing debate, cutaneous inflammation due to inappropriate IgE (auto)antibody-related immune reactions is frequently considered.
Krzysztof Sitko, Marta Bednarek, Jagoda Mantej, Magdalena Trzeciak, Stefan Tukaj   +4 more
openaire   +2 more sources

Heat Shock Proteins and Ferroptosis

Frontiers in Cell and Developmental Biology, 2022
Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize
Ying Liu, Ying Liu, Ying Liu, Ying Liu, Lin Zhou, Lin Zhou, Lin Zhou, Lin Zhou, Yunfei Xu, Yunfei Xu, Yunfei Xu, Yunfei Xu, Kexin Li, Kexin Li, Kexin Li, Kexin Li, Yao Zhao, Yao Zhao, Yao Zhao, Yao Zhao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Haoduo Qiao, Qing Xu, Qing Xu, Qing Xu, Qing Xu, Jie Zhao   +28 more
doaj   +1 more source

Heat shock protein 90 in neurodegenerative diseases

Molecular Neurodegeneration, 2010
Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy, recent evidence from several laboratories suggests a role for Hsp90 in maintaining the functional ...
Rodina Anna, Taldone Tony, Sun Weilin, Luo Wenjie, Chiosis Gabriela   +4 more
doaj   +1 more source

Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus [PDF]

Cancers, 2014
Her2 overexpression and amplification can be found in a significant subset of esophageal adenocarcinomas. The activity of Her2 has been shown to be modulated by molecular chaperones such as HSP90. We analyzed expression/amplification data for HSP90 and Her2 on 127 primary resected esophageal adenocarcinomas in order to evaluate a possible relationship ...
Slotta-Huspenina J, Becker KF, Feith M, Walch A, Langer R   +4 more
openaire   +3 more sources

The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells. [PDF]

PLoS ONE, 2017
Many types of cancer express high levels of heat shock proteins (HSPs) that are molecular chaperones regulating protein folding and stability ensuring protection of cells from potentially lethal stress.
Susanne Schaefer, Tina H Svenstrup, Barbara Guerra   +2 more
doaj   +1 more source

Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates

Frontiers in Molecular Biosciences, 2021
In eukaryotes, the 90-kDa heat shock proteins (Hsp90s) are profusely studied chaperones that, together with 70-kDa heat shock proteins (Hsp70s), control protein homeostasis.
Bruno Fauvet, Andrija Finka, Marie-Pierre Castanié-Cornet, Anne-Marie Cirinesi, Pierre Genevaux, Manfredo Quadroni, Pierre Goloubinoff   +6 more
doaj   +1 more source

Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

ChemistryOpen, 2019
Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency.
Dr. Peng Liu, Dr. Xiangling Chen, Dr. Jianming Zhu, Dr. Bo Li, Dr. Zhaoqiang Chen, Dr. Guimin Wang, Dr. Haiguo Sun, Dr. Zhijian Xu, Dr. Zhixin Zhao, Dr. Chen Zhou, Dr. Chengying Xie, Prof. Liguang Lou, Prof. Weiliang Zhu   +12 more
doaj   +1 more source

Conformational Transitions of Heat Shock Proteins: The Case of Hsp90 [PDF]

Biophysical Journal, 2012
The most abundant cellular protein, Hsp90, partakes in many biological pathways, not only in times of induced stress, but also under normal physiological conditions. Its role in controlling proteostasis, by assisting in protein folding and reducing aggregation, together with its direct involvement in cancer cell survival and neurological disorders ...
Simunovic, Mijo, Voth, Gregory A.
openaire   +1 more source

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

PLoS Pathogens, 2012
Thermal adaptation is essential in all organisms. In yeasts, the heat shock response is commanded by the heat shock transcription factor Hsf1. Here we have integrated unbiased genetic screens with directed molecular dissection to demonstrate that ...
Michelle D Leach, Susan Budge, Louise Walker, Carol Munro, Leah E Cowen, Alistair J P Brown   +5 more
doaj   +1 more source