Results 21 to 30 of about 97,306 (265)
G3: Genes, Genomes, Genetics, 2017 Accumulation of toxic proteins in neurons has been linked with the onset of neurodegenerative diseases, which in many cases are characterized by altered neuronal function and synapse loss.
Sandeep Raut +5 more
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Targeting protein folding in N‐Myc‐driven medulloblastoma
Molecular Oncology, 2023 Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al.
Gintvile Valinciute, Martine F. Roussel
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Blood, 2009 AbstractMultisubunit complexes containing molecular chaperones regulate protein production, stability, and degradation in virtually every cell type. We are beginning to recognize how generalized and tissue-specific chaperones regulate specialized aspects of erythropoiesis.
Mitchell J, Weiss, Camila O, dos Santos
openaire +3 more sources
Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines
Frontiers in Oncology, 2015 The endoplasmic reticulum (ER) is a major site of passage for proteins en route to other organelles, to the cell surface, and to the extracellular space.
Michael William Graner +2 more
doaj +1 more source
Molecular Systems Biology, 2009 Molecular chaperones are known to be involved in many cellular functions, however, a detailed and comprehensive overview of the interactions between chaperones and their cofactors and substrates is still absent.
Yunchen Gong +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar +2 more
doaj +1 more source
Frontiers in Endocrinology, 2019 Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease (MND) caused by a mutant androgen receptor (AR) containing an elongated polyglutamine (polyQ) tract. ARpolyQ toxicity is triggered by androgenic AR ligands, which induce aberrant
Maria Elena Cicardi +16 more
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Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly
Biomolecules, 2022 Whereas assembly of the 20S proteasome core particle (CP) in prokaryotes apparently occurs spontaneously, the efficiency of this process in eukaryotes relies on the dedicated assembly chaperones Ump1, Pba1-Pba2, and Pba3-Pba4.
Ana C. Matias +3 more
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Frontiers in Cellular and Infection Microbiology, 2018 Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar +2 more
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DnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez +7 more
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