Results 31 to 40 of about 183,487 (307)
Frontiers in Molecular Neuroscience, 2017 Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar +2 more
doaj +1 more source
Frontiers in Endocrinology, 2019 Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease (MND) caused by a mutant androgen receptor (AR) containing an elongated polyglutamine (polyQ) tract. ARpolyQ toxicity is triggered by androgenic AR ligands, which induce aberrant
Maria Elena Cicardi +16 more
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Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly
Biomolecules, 2022 Whereas assembly of the 20S proteasome core particle (CP) in prokaryotes apparently occurs spontaneously, the efficiency of this process in eukaryotes relies on the dedicated assembly chaperones Ump1, Pba1-Pba2, and Pba3-Pba4.
Ana C. Matias +3 more
doaj +1 more source
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]
, 2008 The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
R. A. Spooner +32 more
core +4 more sources
Frontiers in Cellular and Infection Microbiology, 2018 Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar +2 more
doaj +1 more source
DnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez +7 more
doaj +1 more source
mSystems, 2021 Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σE network responds to the presence of stressors, such as surfactants that cause surface stress.
Satyajit D. Rao +3 more
doaj +1 more source
Pharmacological Research, 2012 Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however, over the years, the contribution ...
Susmita, Kaushik, Ana Maria, Cuervo
openaire +2 more sources
Non-Equilibrium Protein Folding and Activation by ATP-Driven Chaperones
Biomolecules, 2022 Recent experimental studies suggest that ATP-driven molecular chaperones can stabilize protein substrates in their native structures out of thermal equilibrium. The mechanism of such non-equilibrium protein folding is an open question. Based on available
Huafeng Xu
doaj +1 more source
β-secretase 1´s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
Frontiers in Cellular Neuroscience, 2016 β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD).
Diego ePiedrahita +6 more
doaj +1 more source