Results 31 to 40 of about 110,947 (209)
Frontiers in Endocrinology, 2019 Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease (MND) caused by a mutant androgen receptor (AR) containing an elongated polyglutamine (polyQ) tract. ARpolyQ toxicity is triggered by androgenic AR ligands, which induce aberrant
Maria Elena Cicardi +16 more
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The discovery of SycO reveals a new function for type three secretion effector chaperones [PDF]
, 2006 The Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol.
Letzelter, Michel
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Frontiers in Cellular and Infection Microbiology, 2018 Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar +2 more
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DnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez +7 more
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mSystems, 2021 Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σE network responds to the presence of stressors, such as surfactants that cause surface stress.
Satyajit D. Rao +3 more
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Pharmacological Research, 2012 Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however, over the years, the contribution ...
Susmita, Kaushik, Ana Maria, Cuervo
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Non-Equilibrium Protein Folding and Activation by ATP-Driven Chaperones
Biomolecules, 2022 Recent experimental studies suggest that ATP-driven molecular chaperones can stabilize protein substrates in their native structures out of thermal equilibrium. The mechanism of such non-equilibrium protein folding is an open question. Based on available
Huafeng Xu
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β-secretase 1´s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
Frontiers in Cellular Neuroscience, 2016 β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD).
Diego ePiedrahita +6 more
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Heat shock proteins and viral infection
Frontiers in Immunology, 2022 Heat shock proteins (HSPs) are a kind of proteins which mostly found in bacterial, plant and animal cells, in which they are involved in the monitoring and regulation of cellular life activities.
Xizhen Zhang +3 more
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, 2023 This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government ...
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