Results 11 to 20 of about 94,343 (283)
Identification and in silico expression pattern analysis of Eucalyptus expressed sequencing tags (ESTs) encoding molecular chaperones [PDF]
Genetics and Molecular Biology, 2005 Expressed Sequence Tags (ESTs) sequencing provides reliable and useful information concerning gene expression patterns in the genomic context. Our group used bioinformatics to identify and annotate 5'EST-contigs belonging to the molecular chaperones ...
Thiago C. Cagliari +3 more
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Molecular chaperones and selection against mutations [PDF]
Biology Direct, 2008 Background Molecular chaperones help to restore the native states of proteins after their destabilization by external stress. It has been proposed that another function of chaperones is to maintain the activity of proteins destabilized by mutation ...
Korona Ryszard, Tomala Katarzyna
doaj +3 more sources
Molecular Chaperones and Thyroid Cancer. [PDF]
Int J Mol Sci, 2021 Thyroid cancers are the most common of the endocrine system malignancies and progress must be made in the areas of differential diagnosis and treatment to improve patient management.
Paladino L +9 more
europepmc +5 more sources
Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding. [PDF]
Int J Mol Sci, 2022 Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest ...
Kawagoe S, Ishimori K, Saio T.
europepmc +2 more sources
The redox switch that regulates molecular chaperones [PDF]
Biomolecular Concepts, 2015 Modification of reactive cysteine residues plays an integral role in redox-regulated reactions. Oxidation of thiolate anions to sulphenic acid can result in disulphide bond formation, or overoxidation to sulphonic acid, representing reversible and ...
Conway Myra E., Lee Christopher
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Cells, 2021 The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Molecular chaperones are a major component of the
Lisha Wang +4 more
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Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery
Acta Pharmaceutica Sinica B, 2020 Modulation of protein fate decision and protein homeostasis plays a significant role in altering the protein level, which acts as an orientation to develop drugs with new mechanisms.
Lei Wang +3 more
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Molecular Chaperone Receptors [PDF]
, 2017 Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this
Ayesha, Murshid +3 more
openaire +2 more sources
Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease. [PDF]
, 2007 Evidence is emerging that molecular chaperones, in addition to their intracellular protein folding actions, can act as intercellular signaling proteins with an ability to modulate leukocyte function. Recent evidence has also shown that these proteins can
Alireza Shamaei-Tousi +24 more
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The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment
Frontiers in Neuroscience, 2022 The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER ...
Hongji Sun +4 more
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