Results 21 to 30 of about 3,296,549 (170)

Editorial: Molecular chaperones and human disease [PDF]

Frontiers in Molecular Biosciences, 2022
Graham Chakafana, Stanley Makumire, Xolani Henry Makhoba   +2 more
doaj   +2 more sources

Editorial: Molecular chaperones and polyamines in disease [PDF]

Frontiers in Molecular Biosciences
Stanley Makumire, Graham Chakafana, Xolani H. Makhoba   +2 more
doaj   +2 more sources

Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding. [PDF]

Int J Mol Sci, 2022
Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest ...
Kawagoe S, Ishimori K, Saio T.
europepmc   +2 more sources

Molecular Chaperones and Thyroid Cancer. [PDF]

Int J Mol Sci, 2021
Thyroid cancers are the most common of the endocrine system malignancies and progress must be made in the areas of differential diagnosis and treatment to improve patient management.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F.   +9 more
europepmc   +2 more sources

Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

Cells, 2021
The dysfunction of the proteostasis network is a molecular hallmark of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Molecular chaperones are a major component of the
Lisha Wang, Liza Bergkvist, Rajnish Kumar, Bengt Winblad, Pavel F. Pavlov   +4 more
doaj   +1 more source

Pharmacological therapies for monogenic obesity caused by MC4R dysfunction [PDF]

, 2010
PhDMutations in the melanocortin-4 receptor (MC4R) are the most common cause of monogenic obesity. The majority of MC4R mutations are predicted to cause the receptor to aberrantly fold.
Gooljar, Sakina B
core   +4 more sources

Molecular Chaperones: Molecular Assembly Line Brings Metabolism and Immunity in Shape

Metabolites, 2020
Molecular chaperones are a set of conserved proteins that have evolved to assist the folding of many newly synthesized proteins by preventing their misfolding under conditions such as elevated temperatures, hypoxia, acidosis and nutrient deprivation ...
Haoxin Zhao, Lydia N. Raines, Stanley Ching-Cheng Huang   +2 more
doaj   +1 more source

Molecular Chaperone Receptors [PDF]

, 2017
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors expressed on a wide range of cell types. We have investigated the nature of such proteins by cloning candidate receptors into cells (CHO-K1) with the rare property of being null for HSP binding. Using this
Ayesha, Murshid, Jimmy, Theriault, Jianlin, Gong, Stuart K, Calderwood   +3 more
openaire   +2 more sources

Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease. [PDF]

, 2007
Evidence is emerging that molecular chaperones, in addition to their intracellular protein folding actions, can act as intercellular signaling proteins with an ability to modulate leukocyte function. Recent evidence has also shown that these proteins can
Alireza Shamaei-Tousi, Francesco D'Aiuto, D'Aiuto Francesco, D'Aiuto, F, Coates, ARM, Henderson Brian, Henderson, B, Donos, N, Brian Henderson, Shamaei-Tousi Alireza, Coates, AR, Nibali Luigi, Coates Anthony R. M., Donos Nikos, Mohamed Parkar, Nibali, L, Parkar, M, Parkar Mohamed, Luigi Nibali, Andrew Steptoe, Anthony R M Coates, Steptoe Andrew, Steptoe, A, Shamaei-Tousi, A, Nikos Donos   +24 more
core   +2 more sources

The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment

Frontiers in Neuroscience, 2022
The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER ...
Hongji Sun, Mengxue Wu, Minxin Wang, Xiaomin Zhang, Jia Zhu   +4 more
doaj   +1 more source