Results 91 to 100 of about 43,964 (292)

Proteostasis of Huntingtin in Health and Disease

, 2017
Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by motor dysfunction, cognitive deficits and psychosis. HD is caused by mutations in the Huntingtin (HTT) gene, resulting in the expansion of polyglutamine (polyQ) repeats in ...
Ricardo Gutierrez-Garcia, Azra Fatima, David Vilchez, Seda Koyuncu   +3 more
core   +1 more source

Host proteostasis modulates influenza evolution [PDF]

, 2017
Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens.
Butty, Vincent L G, Stuart S Levine, Yu-Shan Lin, Luna O Gonzalez, Leonid A Mirny, Sean M McHugh, Mirny, Leonid A, Emmanuel E Nekongo, Angela M Phillips, Gonzalez, Luna O., Anna I Ponomarenko, McHugh, Sean M, Matthew D Shoulders, Nekongo, Emmanuel E, Lin, Yu-Shan, Levine, Stuart S., Ponomarenko, Anna, Shoulders, Matthew D., Vincent L Butty, Phillips, Angela Marie   +19 more
core   +1 more source

Dietary-Induced Signals That Activate the Gonadal Longevity Pathway during Development Regulate a Proteostasis Switch in Caenorhabditis elegans Adulthood

Frontiers in Molecular Neuroscience, 2017
Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis).
Netta Shemesh, Lana Meshnik, Nufar Shpigel, Anat Ben-Zvi   +3 more
doaj   +1 more source

The Nuclear Lamina: Protein Accumulation and Disease

Biomedicines, 2020
Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw   +7 more
doaj   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

PROTEOSTASIS AS A SIGNALING DEVICE AND THERAPEUTIC TARGET

, 2011
The term ‘conformational disorders’ was created recently for the numerous pathological situations due to the accumulation of aberrant proteins (or normal ones in excess).
CENCI S, SITIA , ROBERTO
core  

TFEB regulates lysosomal proteostasis

, 2013
Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby
di Ronza, Alberto, Ake, Ashley, Song, Wensi, Wang, Fan, Savini, Marzia, Sardiello, Marco, Segatori, Laura   +6 more
core   +1 more source

Endoplasmic reticulum proteostasis impairment in aging [PDF]

, 2017
Summary Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, folding, trafficking ...
Hetz, Claudio, Felipe Cabral‐Miranda, Juan P. Vivar, Claudia Duran‐Aniotz, Cabral‐Miranda, Felipe, Duran‐Aniotz, Claudia, Claudio Hetz, Durán Aniotz, Claudia, Gabriela Martínez, Hetz Flores, Claudio, Martínez, Gabriela, Martínez Bravo, Gabriela, Cabral Miranda, Felipe, Vivar, Juan P.   +13 more
core   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source