Results 91 to 100 of about 57,493 (305)

Regulation of cell-­nonautonomous proteostasis in metazoans [PDF]

, 2016
Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability.
O'Brien, D, Van Oosten-Hawle, PC
core   +1 more source

Aging as an Event of Proteostasis Collapse [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer's and Huntington's.
Taylor, Rebecca C., Dillin, Andrew
openaire   +3 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Probing the Proteostasis Network

Chemistry & Biology, 2010
PTI has built itself up as an entity that can test the concept of proteostasis modulators. The company is using its capabilities in transcriptional, proteomic, and functional profiling to probe the proteostasis network in human diseases. “The goal of all of this work is to increase the health span, the number of years we are healthy,” says Kelly.To ...
openaire   +2 more sources

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity

Nature Communications
Polymers can facilitate detergent-free extraction of membrane proteins into nanodiscs (e.g., SMALPs, DIBMALPs), incorporating both integral membrane proteins as well as co-extracted native membrane lipids.
Henry Sawczyc, Takashi Tatsuta, Carl Öster, Spyridon Kosteletos, Sascha Lange, Claudia Bohg, Thomas Langer, Adam Lange   +7 more
doaj   +1 more source

Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans

Cells, 2018
Proteostasis is of vital importance for cellular function and it is challenged upon exposure to acute or chronic insults during neurodegeneration and aging.
Andreas Kern, Natalie Spang, Heike Huesmann, Christian Behl   +3 more
doaj   +1 more source

Cellular proteostasis: degradation of misfolded proteins by lysosomes [PDF]

, 2016
Proteostasis refers to the regulation of the cellular concentration, folding, interactions and localisation of each of the proteins that comprise the proteome.
Hewitt, EW, Jackson, MP
core   +1 more source

The proteostasis burden of aneuploidy

Biological Chemistry
Abstract Aneuploidy refers to chromosome number abnormality that is not an exact multiple of the haploid chromosome set. Aneuploidy has largely negative consequences in cells and organisms, manifested as so-called aneuploidy-associated stresses.
Prince Saforo Amponsah, Zuzana Storchová   +1 more
openaire   +2 more sources

Special Issue on “Proteostasis and Autophagy” [PDF]

Cells, 2019
Autophagy is a highly conserved eukaryotic pathway responsible for the lysosomal degradation (and subsequent recycling) of cellular components such as proteins, protein aggregates, and a growing number of organelles or cellular compartments [...]
Andreas Kern, Christian Behl
openaire   +3 more sources