Results 71 to 80 of about 48,911 (292)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The Pharmacology and Dual Role of Proteostasis in Amyloidoses

Biophysica
Cellular protein quality control comprises the ubiquitin proteasome system, autophagy, and molecular chaperones, which maintain proteostasis in healthy tissues.
Angela Albanese, Manasi M. Natu, Paul M. Seidler   +2 more
doaj   +1 more source

Extracellular proteostasis prevents aggregation during pathogenic attack

, 2020
In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells.
Della C. David, Huang, Chaolie, Sommer, Ralf J., Ralf J. Sommer, Sandhu, Aneet, Jung, Raimund, Christian Rödelsperger, Sommer, R., Rödelsperger, C., David, D., Gallotta, Ivan, Ivan Gallotta, Waltraud Röseler, Huang, C., Sandhu, A., Blersch, J., Aneet Sandhu, Raimund Jung, Gallotta, I., Sinem Agilkaya, Rödelsperger, Christian, Agilkaya, Sinem, Röseler, Waltraud, Agilkaya, S., Blersch, Jane L., Jane L. Blersch, Chaolie Huang, Jung, R., Maximilian Peters, Röseler, W., David, Della C., Haslbeck, M., Martin Haslbeck, Peters, M.   +33 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Meeting Report – proteostasis in Ericeira

, 2018
It was a sunny Ericeira, in Portugal, that received the participants of the EMBO Workshop on Proteostasis, from 17 to 21 November 2017. Most participants gave talks or presented posters concerning their most recent research results, and lively scientific
Sivan Henis-Korenblit, Pedro M. Domingos, Colin Adrain   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Balancing act: navigating the intricacies of proteostasis [PDF]

Proteostasis, the intricate balance of protein synthesis, folding, trafficking, and degradation, is a fundamental cellular process crucial for maintaining cellular health and homeostasis.
Shukla, Manisha, Ahad, Mohammad Abdul
core   +1 more source

Crosstalk between Biomolecular Condensates and Proteostasis

, 2022
Proper homeostasis of the proteome, referred to as proteostasis, is maintained by chaperone-dependent refolding of misfolded proteins and by protein degradation via the ubiquitin-proteasome system and the autophagic machinery.
Amzallag, Emmanuel, Hornstein, Eran, Emmanuel Amzallag, Eran Hornstein   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source