Results 51 to 60 of about 22,982,554 (304)

UPS-dependent strategies of protein quality control degradation.

TIBS -Trends in Biochemical Sciences. Regular ed
The degradation of damaged proteins is critical for tissue integrity and organismal health because damaged proteins have a high propensity to form aggregates.
Leonie Müller, T. Hoppe
semanticscholar   +1 more source

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. [PDF]

, 2012
The generation of affinity reagents to large numbers of human proteins depends on the ability to express the target proteins as high-quality antigens. The Structural Genomics Consortium (SGC) focuses on the production and structure determination of human
Savitsky, P, Daga, N, Allerston, Charles K., Gileadi, Opher, Mahajan, Pravin, Susanne Gräslund, Charles K. Allerston, Opher Gileadi, Hammarström, Martin, Müller, Susanne, Phillips, Claire, Nicola A. Burgess-Brown, Keates, Tracy, Pravin Mahajan, Allerston, CK, Claire Phillips, Christopher D.O. Cooper, Neha Daga, Martin Hammarström, Georgina Berridge, Gräslund, Susanne, Berridge, G, Susanne Müller, Pavel Savitsky, Burgess-Brown, NA, Savitsky, Pavel, Keates, T, Mahajan, P, Tracy Keates, Daga, Neha, Berridge, Georgina, Burgess-Brown, Nicola A., Cooper, CDO, Cooper, Christopher D.O., Phillips, C, Hammarstrom, M   +35 more
core   +1 more source

Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network [PDF]

, 2020
Alzheimer’s Disease is driven by protein aggregation and is characterized by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the ...
Rüdiger, Stefan G.D., Koopman, Margreet B., Sub Cellular Protein Chemistry, Cellular Protein Chemistry   +3 more
core  

Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions

Cells
As ovarian cancer progresses, increased glucose use causes a glucose shortage in the tumor microenvironment. Therefore, it is crucial to find drugs that can effectively kill cancer cells in this energy stress setting.
Yulun Wu, Ziying Zhang, Minhui Ren, Yao Chen, Jingying Zhang, Jiarui Li, Feng Gao, Yongli Bao, Yanxin Huang, Xiaoguang Yang, Zhenbo Song   +10 more
doaj   +1 more source

Ocins for Food Safety

Frontiers in Microbiology, 2019
The food industry produces highly perishable products. Food spoilage represents a severe problem for food manufacturers. Therefore, it is important to identify effective preservation solutions to prevent food spoilage.
Shilja Choyam, Shilja Choyam, Alok Kumar Srivastava, Jae-Ho Shin, Rajagopal Kammara, Rajagopal Kammara   +5 more
doaj   +1 more source

Protein Quality Control in Plant Organelles: Current Progress and Future Perspectives.

Molecular Plant, 2020
The endoplasmic reticulum, chloroplasts, and mitochondria are major plant organelles for protein synthesis, photosynthesis, metabolism, and energy production.
Jing-Liang Sun, Jin-Yu Li, Mei-Jing Wang, Ze-Ting Song, Jian-Xiang Liu   +4 more
semanticscholar   +1 more source

Integrating quality control and external quality assurance

, 2021
Effective management of clinical laboratories relies upon an understanding of Quality Control and External Quality Assurance principles. These processes, when applied effectively, reduce patient risk and drive quality improvement. In this Review, we will
Badrick, Tony, Tony Badrick
core   +1 more source

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

Journal of Advanced Research
Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.
Yulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng, Luguo Sun, Zhenbo Song   +11 more
doaj   +1 more source

Modulating protein quality control

eLife, 2016
Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
Lars Plate, Ryan J Paxman, R Luke Wiseman, Jeffery W Kelly   +3 more
doaj   +1 more source

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

eLife, 2020
The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Lan Wang, Alexander Myasnikov, Xingjie Pan, Peter Walter   +3 more
doaj   +1 more source