Results 51 to 60 of about 1,305,355 (298)

Protein Quality Control in Health and Disease [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Maintaining functional protein homeostasis (proteostasis) is a constant challenge in the face of limited protein-folding capacity, environmental threats, and aging. Cells have developed several quality-control mechanisms that assist nascent polypeptides to fold properly, clear misfolded molecules, respond to the accumulation of protein aggregates, and ...
Tatyana, Dubnikov, Tziona, Ben-Gedalya, Ehud, Cohen   +2 more
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Structural studies of ER-associated protein quality control systems

, 2023
ER-associated protein degradation (ERAD) is an important degradation pathway for the removal of misfolded proteins from the endoplasmic reticulum (ER). This pathway encompasses a set of evolutionary conserved mechanisms for the selection, ubiquitination ...
Robson-Tull, Jacob
core   +1 more source

Quality control of protein folding: an overview [PDF]

The FEBS Journal, 2012
Here a brief introduction to the series is given, which highlights concepts, recent findings and current challenges in understanding chaperone function and quality control of proteins.
openaire   +2 more sources

Ocins for Food Safety

Frontiers in Microbiology, 2019
The food industry produces highly perishable products. Food spoilage represents a severe problem for food manufacturers. Therefore, it is important to identify effective preservation solutions to prevent food spoilage.
Shilja Choyam, Shilja Choyam, Alok Kumar Srivastava, Jae-Ho Shin, Rajagopal Kammara, Rajagopal Kammara   +5 more
doaj   +1 more source

Ubiquitin receptors and protein quality control [PDF]

Journal of Molecular and Cellular Cardiology, 2013
Protein quality control (PQC) is essential to intracellular proteostasis and is carried out by sophisticated collaboration between molecular chaperones and targeted protein degradation. The latter is performed by proteasome-mediated degradation, chaperone-mediated autophagy (CMA), and selective macroautophagy, and collectively serves as the final line ...
Xuejun, Wang, Erin J M, Terpstra
openaire   +2 more sources

Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions

Cells
As ovarian cancer progresses, increased glucose use causes a glucose shortage in the tumor microenvironment. Therefore, it is crucial to find drugs that can effectively kill cancer cells in this energy stress setting.
Yulun Wu, Ziying Zhang, Minhui Ren, Yao Chen, Jingying Zhang, Jiarui Li, Feng Gao, Yongli Bao, Yanxin Huang, Xiaoguang Yang, Zhenbo Song   +10 more
doaj   +1 more source

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

eLife, 2020
The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Lan Wang, Alexander Myasnikov, Xingjie Pan, Peter Walter   +3 more
doaj   +1 more source

Protein quality control in the endoplasmic reticulum [PDF]

F1000Prime Reports, 2014
THE TOPOLOGICAL BARRIERS DEFINED BY BIOLOGICAL MEMBRANES ARE NOT IMPERMEABLE: from small solutes to intact proteins, specialized transport and translocation mechanisms adjust to the cell's needs. Here, we review the removal of unwanted proteins from the endoplasmic reticulum (ER) and emphasize the need to extend observations from tissue culture models ...
Koenig, Paul-Albert, Ploegh, Hidde L.
openaire   +2 more sources

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

Journal of Advanced Research
Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear.
Yulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng, Luguo Sun, Zhenbo Song   +11 more
doaj   +1 more source

Quality control of integral membrane proteins

Trends in Biochemical Sciences, 2004
Integral membrane proteins (IMPs) are essential components of the plasma and organellar membranes of the eukaryotic cell. Non-native IMPs, which can arise as a result of mutations, errors during biosynthesis or cellular stress, can disrupt these membranes and potentially lead to cell death.
Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ), Krebs, Mark P. ( author ), Noorwez, Syed M. ( author ), Malhotra, Ritu ( author ), Kaushal, Shalesh ( author )   +4 more
openaire   +3 more sources